A isolated retinal macrocyst secondary to chronic retinal detachment

A isolated retinal macrocyst secondary to chronic retinal detachment | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report A isolated retinal macrocyst secondary to chronic retinal detachment Qiang Wu, Ying Chen, Liguo Feng This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7356123/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose We presented a case of isolated retinal macrocyst secondary to chronic retinal detachment. A novel surgical approach was described. Case presentation A 44-year-old woman presented with a isolated retinal macrocyst in the region of retinal detachment. An exscleral puncture and fluid drainage was performed with the assistance of 23G intraocular illumination. On the first postoperative day, the retina was reattachment and the macrocyst had completely resolved. One month after surgery, the retina was well restored and retinal macrocyst disappeared completely, which was verified by B-ultrasound. Conclusion Isolated retinal macrocyst is common in chronic retinal detachment. The extrascleral puncture under intraocular illumination is a selective surgical approach for this entity. retinal macrocyst chronic retinal detachment scleral buckling extrascleral puncture swept source optical coherence tomography Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Background Retinal macrocysts develop in the outer plexiform layer [1], which are considered as medium size (8-10 optic disc diameters) and have clear demarcation lines and smooth surfaces [2]. Isolated macrocyst were usually thought to be associated with chronic retinal detachment[3,4]. Different surgical interventions have been reported for managements of retinal macrocysts combined with chronic retinal detachment, such as scleral buckling with or without extrascleral puncture, pars plana vitrectomy (PPV), with or without scleral buckling [3,5,6]. However, surgical results were varied. Macrocysts often could be resolving spontaneously after surgery of retinal reattachment. Here, we report a case of Retinal macrocyst secondary to chronic retinal detachment. A novel surgical approach for this entity is presented. Case presentation A 44-year-old woman presented with blurred vision for 2 days in the right eye. The best corrected visual acuity of right eye (BCVA) was 0.7. slit-lamp exanimation showed a silent anterior segment. Dilated fundus revealed vitreous opacity with pigmented granules, an inferior retinal detachment and a hyperpigmented ring formed at the edge of the retinal detachment (Figure 1a and Figure 1b). a isolated retinal macrocyst in the region of retinal detachment was verified by B-ultrasound (Figure 1c). No obvious retinal hole was found, but a suspected intraretinal hole with vitreous coverage was seen at 5:30-o’clock positions below in the macrocyst. Optical coherence tomography highlighted a macular pucker with retinal thickening but no subretinal fluid (Figure 1d). An exscleral puncture and fluid drainage was performed with the assistance of 23G intraocular illumination. Specifically, after making the 23-gauge scleral puncture channel, locate the point of the extrascleral puncture at about 6:30 below, 12mm behind the limbus. Then under intraocular illumination, a 30-G needle was punctured into the sclera and into the retinal macrocyst, where light yellowish fluids could be seen flowing into the syringe. After withdrawing the needle and gently squeezing the scleral puncture port, relatively clear fluid outflow was observed until there was no obvious fluid outflow. Then a cryotherapy was carried out and a silicone sponge was placed. At the end of the operation, the macrocyst had regressed completely (supplementary material (video )). On the first postoperative day, BCVA was 0.6, the intraocular pressure (IOP) was 15.3mmHg, fundus examination showed that the retina was reattachment, and B-ultrasound confirmed that the cyst had completely resolved (Figure 2). OCT showed that the retinal thickness had improved. One week after surgery, BCVA was stable, IOP was 12.5mmHg, fundus examination showed that the retina was silent (Figure 3), and B-ultrasound confirmed the disappearance of the macrocyst. One month after surgery, the retina was well restored and retinal macrocyst disappeared completely (Figure 4), which was further verified by B-ultrasound (Figure 5). swept source optical coherence tomography (SS-OCT) showed that the macular was silent and no retinal cysts were seen (Figure 6). Discussion Retinal cysts are common in chronic retinal detachment, which mainly occur in the outer plexiform layer of the retina. Based on pischel's study, retinal cysts are divided into four types: small (less than 1mm in size ), medium (4-8 optic disc diameters), giant (8-10 optic disc diameters), and large cysts (retinoschisis) [2]. Venkatkrish et al reported a case of chronic retinal detachment with multiple retinal macrocysts in a pediatric patient with stickle syndrome [7]. Our case belongs to the category of giant retinal cyst. As in previous ultrasonography [8], the characteristic of the retinal macrocysts, such as inactivity and a thin wall,was also shown. There have been many clinical reports on the management of chronic retinal detachment with retinal giant cysts. Marcus showed good clinical results through scleral encircling or buckling, combined with scleral puncture drainage, but not all retinal cysts collapsed completely [4]. Wang has also recently reported very good results in the treatment of retinal bloody cysts by combining scleral encircling with extrascleral puncture drainage [6]. Venkatkrish et al reported successfully retinal reattachement in a patient with a chronic retinal detachment with multiple retinal macrocysts through scleral buckling, subretinal fluid drainage, cryotherapy, and a SF6 tamponade [7]. With the popularization of vitreoretinal surgery, vitrectomy for the treatment of retinal cysts has also been reported. Mikuni et al has achieved good clinical results by vitrectomy combined with scleral encircling for multiple retinal cysts [9]. Also, Verdaguer et al performed vitrectomy combined with retinotomy to remove the retinal cyst intact [10]. Similarly, Cai et al also reported the removal of retinal cysts and reattachment of the detached retina by vitrectomy combined with retinotomy, silicone oil tamponade [5]. In this study, using the operating microscope and intraocular illumination, the puncture and drainage of the scleral cyst and local placement of silicone sponge were completed under direct vision, and the postoperative results were satisfactory. In Marcus's study, extrascleral crypotherapy was not performed on the puncture site [4]. In this study, the crypotherapy of the scleral puncture site was clearly completed under intraocular illumination. Conclusion Isolated retinal macrocyst is common in chronic retinal detachment. The extrascleral puncture under intraocular illumination is a selective surgical approach for this entity. Declarations Acknowledgements Not applicable Authors’ contributions LgF collected and interpreted the data and critically reviewed the literature. QW drafted this manuscript. QW collected the data. LgF and YCh critically reviewed the final version of the manuscript. All authors have read and approved the final manuscript. Funding No funding Data availability Data is provided within the manuscript and related files. Ethics approval and consent to participate This study was conducted in accordance with the Declaration of Helsinki, and the patient signed an informed consent for the use of human materials and data mentioned in this report for scientific research. Consent for publication Written informed consent for publication was obtained from the patient. Competing interests The authors declare no competing interests References Cibis PA. Retinoschisis: retinal cysts. Trans Am Ophthalmol Soc 1965; 63: 417-53. Pischel DK: Surgical treatment of retinal cysts. Am J Ophthalmol 1963; 56:1-16. Liu TYA, Vizcaino MA, Eberhart CG, Sachdeva MM. Association of macular and peripheral retinal macropseudocysts with chronic retinal detachment. JAMA Ophthalmol 2018;136:956–958. Marcus DF, Aaberg TM. Intraretinal macrocysts in retinal detachment. Arch Ophthalmol. 1979; 97:1273–5. Cai C, Zhou J, Wang Q, Li W, Liu D. Case report: an intraretinal macrocyst with crystalline content and retinal detachment. Front Med (Lausanne) 2022;9:1051181. Wang Y, Cao X, Jia P, et al. Retinal giant cyst treated by the scleral buckling procedure: a case report. Medicine (Baltimore) 2024;103(13): e37620. Venkatkrish M. Kasetty, Kaitlin R. Regan, Jennifer Aye, Tyler Looysen, Nish Patel, Abdualrahman E. Hamad.chronic pediatric retinal detachement with multiple macrocysts. Retinal case & brief reports.2023; 17:758-762. Juan Carlos Serna-Ojeda, Christian Denisse Pinkus-Herrera, Maria Victoria Moreno-Londono, Jose Luis Rodriguez-Loaiza, Maria Cristina Gonzalez-Gonzalez.Clinical and Echographic Long-Term Follow-Up of a Retinal Macrocyst: A Case Report. Case Rep Ophthalmol 2014;5:168–171. Shota Mikuni , Yoshio Hirano , Takaaki Yuguchi , Hiroshi Morita , Tsutomu Yasukawa .A Case of Total Retinal Detachment With Multiple Retinal Cysts Showing a Favorable Postoperative Course.Cureus 2025;17(4): e82111. Paula Verdaguer, Jeroni Nadal. Intraretinal cyst secondary to longstanding retinal Detachment.Eur J Ophthalmol 2012 ; 22 (3): 506-508. Additional Declarations No competing interests reported. Supplementary Files MyVideo.mp4 Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7356123","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":505978355,"identity":"52484923-ce19-4a02-a9ff-993093ec9e9c","order_by":0,"name":"Qiang Wu","email":"","orcid":"","institution":"Zhejiang University School of Medicine","correspondingAuthor":false,"prefix":"","firstName":"Qiang","middleName":"","lastName":"Wu","suffix":""},{"id":505978356,"identity":"5c0e28f5-afbf-4562-8c78-a72b93979239","order_by":1,"name":"Ying Chen","email":"","orcid":"","institution":"Zhejiang University School of 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2","display":"","copyAsset":false,"role":"figure","size":31852,"visible":true,"origin":"","legend":"\u003cp\u003eOn the first postoperative day, the cyst had completely resolved.\u003c/p\u003e","description":"","filename":"figure2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7356123/v1/923b5432f3c9e93eaa11ff93.jpg"},{"id":90305956,"identity":"2d64fcc8-5987-4f97-aeb1-ddfc746a6631","added_by":"auto","created_at":"2025-09-01 09:25:30","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":108604,"visible":true,"origin":"","legend":"\u003cp\u003eOne week after surgery, the retina was reattachment.\u003c/p\u003e","description":"","filename":"figure3.tiff.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7356123/v1/d611da826a53dce5dd5331b2.jpg"},{"id":90307661,"identity":"dbca1b95-bab4-422d-a99f-4323631294f8","added_by":"auto","created_at":"2025-09-01 09:33:30","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":88984,"visible":true,"origin":"","legend":"\u003cp\u003eOne month after surgery, the retina was reattachment.\u003c/p\u003e","description":"","filename":"figure4.tiff.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7356123/v1/4aa283c23b59db291d901a38.jpg"},{"id":90305958,"identity":"f3f5c527-2265-45f0-bfb4-181e0f41f323","added_by":"auto","created_at":"2025-09-01 09:25:30","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":92701,"visible":true,"origin":"","legend":"\u003cp\u003eThe retinal macrocyst disappeared completely on B-ultrasound.\u003c/p\u003e","description":"","filename":"figure5.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7356123/v1/6f33d6ccfe3ad15321c01983.jpg"},{"id":90305960,"identity":"7d44bf78-67d4-43fa-b82c-4b2dc809c70f","added_by":"auto","created_at":"2025-09-01 09:25:30","extension":"jpg","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":528656,"visible":true,"origin":"","legend":"\u003cp\u003eThe macular was silent on SS-OCT\u003c/p\u003e","description":"","filename":"figure6.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7356123/v1/9a90ac3c4b32e0d08faa7bfd.jpg"},{"id":99791883,"identity":"df0df882-ee84-4472-a4e2-e6afefa6fcd2","added_by":"auto","created_at":"2026-01-08 13:11:26","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1834611,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7356123/v1/c2b695a1-93c5-4827-a64a-2cbbfd3c9906.pdf"},{"id":90305996,"identity":"ad8bbabc-bc26-4372-b872-40b11867e51c","added_by":"auto","created_at":"2025-09-01 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Isolated macrocyst were usually thought to be associated with chronic retinal detachment[3,4]. Different surgical interventions have been reported for managements of retinal macrocysts combined with chronic retinal detachment, such as scleral buckling with or without extrascleral puncture, pars plana vitrectomy (PPV), with or without scleral buckling [3,5,6]. However, surgical results were varied. Macrocysts often could be resolving spontaneously after surgery of retinal reattachment. Here, we report a case of Retinal macrocyst secondary to chronic retinal detachment. A novel surgical approach for this entity is presented.\u003c/p\u003e"},{"header":"Case presentation","content":"\u003cp\u003eA 44-year-old woman presented with blurred vision for 2 days in the right eye. The best corrected visual acuity of right eye (BCVA) was 0.7. slit-lamp exanimation showed a silent anterior segment. Dilated fundus revealed vitreous opacity with pigmented granules, an inferior retinal detachment and a hyperpigmented ring formed at the edge of the retinal detachment (Figure 1a and Figure 1b). a isolated retinal macrocyst in the region of retinal detachment was verified by B-ultrasound (Figure 1c). No obvious retinal hole was found, but a suspected intraretinal hole with vitreous coverage was seen at 5:30-o\u0026rsquo;clock positions below in the macrocyst. Optical coherence tomography highlighted a macular pucker with retinal thickening but no subretinal fluid (Figure 1d).\u003c/p\u003e\n\u003cp\u003eAn exscleral puncture and fluid drainage was performed with the assistance of 23G intraocular illumination. Specifically, after making the 23-gauge scleral puncture channel, locate the point of the extrascleral puncture at about 6:30 below, 12mm behind the limbus. Then under intraocular illumination, a 30-G needle was punctured into the sclera and into the retinal macrocyst, where light yellowish fluids could be seen flowing into the syringe. After withdrawing the needle and gently squeezing the scleral puncture port, relatively clear fluid outflow was observed until there was no obvious fluid outflow. Then a cryotherapy was carried out and a silicone sponge was placed. At the end of the operation, the macrocyst had regressed completely (supplementary material (video )).\u003c/p\u003e\n\u003cp\u003eOn the first postoperative day, BCVA was 0.6, the intraocular pressure (IOP) was 15.3mmHg, fundus examination showed that the retina was reattachment, and B-ultrasound confirmed that the cyst had completely resolved (Figure 2). OCT showed that the retinal thickness had improved. One week after surgery, BCVA was stable, IOP was 12.5mmHg, fundus examination showed that the retina was silent (Figure 3), and B-ultrasound confirmed the disappearance of the macrocyst. One month after surgery, the retina was well restored and retinal macrocyst disappeared completely (Figure 4), which was further verified by B-ultrasound (Figure 5). swept source optical coherence tomography (SS-OCT) showed that the macular was silent and no retinal cysts were seen (Figure 6).\u003c/p\u003e"},{"header":"Discussion ","content":"\u003cp\u003eRetinal cysts are common in chronic retinal detachment, which mainly occur in the outer plexiform layer of the retina. Based on pischel\u0026apos;s study, retinal cysts are divided into four types: small (less than 1mm in size ), medium (4-8 optic disc diameters), giant (8-10 optic disc diameters), and large cysts (retinoschisis) [2]. Venkatkrish et al reported a case of chronic retinal detachment with multiple retinal macrocysts in a pediatric patient with stickle syndrome [7]. Our case belongs to the category of giant retinal cyst. As in previous ultrasonography [8], the characteristic of the retinal macrocysts, such as inactivity and a thin wall,was also shown.\u003c/p\u003e\n\u003cp\u003eThere have been many clinical reports on the management of chronic retinal detachment with retinal giant cysts. Marcus showed good clinical results through scleral encircling or buckling, combined with scleral puncture drainage, but not all retinal cysts collapsed completely [4]. Wang has also recently reported very good results in the treatment of retinal bloody cysts by combining scleral encircling with extrascleral puncture drainage [6]. Venkatkrish et al reported successfully retinal reattachement in a patient with a chronic retinal detachment with multiple retinal macrocysts through scleral buckling, subretinal fluid drainage, cryotherapy, and a SF6 tamponade [7]. With the popularization of vitreoretinal surgery, vitrectomy for the treatment of retinal cysts has also been reported. Mikuni et al has achieved good clinical results by vitrectomy combined with scleral encircling for multiple retinal cysts [9]. Also, Verdaguer et al performed vitrectomy combined with retinotomy to remove the retinal cyst intact [10]. Similarly, Cai et al also reported the removal of retinal cysts and reattachment of the detached retina by vitrectomy combined with retinotomy, silicone oil tamponade [5]. In this study, using the operating microscope and intraocular illumination, the puncture and drainage of the scleral cyst and local placement of silicone sponge were completed under direct vision, and the postoperative results were satisfactory. In Marcus\u0026apos;s study, extrascleral crypotherapy was not performed on the puncture site [4]. In this study, the crypotherapy of the scleral puncture site was clearly completed under intraocular illumination.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIsolated retinal macrocyst is common in chronic retinal detachment. The extrascleral puncture under intraocular illumination is a selective surgical approach for this entity.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;LgF collected and interpreted the data and critically reviewed the literature. QW drafted this manuscript. QW collected the data. LgF and YCh critically reviewed the final version of the manuscript. All authors have read and approved the final manuscript.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo funding\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData availability\u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eData is provided within the manuscript and related files.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThis study was conducted in accordance with the Declaration of Helsinki, and the patient signed an informed consent for the use of human materials and data mentioned in this report for scientific research.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWritten informed consent for publication was obtained from the patient.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing interests\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eCibis PA. Retinoschisis: retinal cysts. Trans Am Ophthalmol Soc 1965; 63: 417-53.\u003c/li\u003e\n\u003cli\u003ePischel DK: Surgical treatment of retinal cysts. Am J Ophthalmol 1963; 56:1-16.\u003c/li\u003e\n\u003cli\u003eLiu TYA, Vizcaino MA, Eberhart CG, Sachdeva MM. Association of macular and peripheral retinal macropseudocysts with chronic retinal detachment. JAMA Ophthalmol 2018;136:956\u0026ndash;958.\u003c/li\u003e\n\u003cli\u003eMarcus DF, Aaberg TM. Intraretinal macrocysts in retinal detachment. Arch Ophthalmol. 1979; 97:1273\u0026ndash;5.\u003c/li\u003e\n\u003cli\u003eCai C, Zhou J, Wang Q, Li W, Liu D. Case report: an intraretinal macrocyst with crystalline content and retinal detachment. Front Med (Lausanne) 2022;9:1051181.\u003c/li\u003e\n\u003cli\u003eWang Y, Cao X, Jia P, et al. Retinal giant cyst treated by the scleral buckling procedure: a case report. Medicine (Baltimore) 2024;103(13): e37620. \u003c/li\u003e\n\u003cli\u003eVenkatkrish M. Kasetty, Kaitlin R. Regan, Jennifer Aye, Tyler Looysen, Nish Patel, Abdualrahman E. Hamad.chronic pediatric retinal detachement with multiple macrocysts. Retinal case \u0026amp; brief reports.2023; 17:758-762.\u003c/li\u003e\n\u003cli\u003eJuan Carlos Serna-Ojeda, Christian Denisse Pinkus-Herrera, Maria Victoria Moreno-Londono, Jose Luis Rodriguez-Loaiza, Maria Cristina Gonzalez-Gonzalez.Clinical and Echographic Long-Term Follow-Up of a Retinal Macrocyst: A Case Report. Case Rep Ophthalmol 2014;5:168\u0026ndash;171.\u003c/li\u003e\n\u003cli\u003eShota Mikuni , Yoshio Hirano , Takaaki Yuguchi , Hiroshi Morita , Tsutomu Yasukawa .A Case of Total Retinal Detachment With Multiple Retinal Cysts Showing a Favorable Postoperative Course.Cureus 2025;17(4): e82111.\u003c/li\u003e\n\u003cli\u003ePaula Verdaguer, Jeroni Nadal. Intraretinal cyst secondary to longstanding retinal Detachment.Eur J Ophthalmol 2012 ; 22 (3): 506-508.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"retinal macrocyst, chronic retinal detachment, scleral buckling, extrascleral puncture, swept source optical coherence tomography","lastPublishedDoi":"10.21203/rs.3.rs-7356123/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7356123/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003ePurpose\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe presented a case of isolated retinal macrocyst secondary to chronic retinal detachment. A novel surgical approach was described.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCase presentation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA 44-year-old woman presented with a isolated retinal macrocyst in the region of retinal detachment. An exscleral puncture and fluid drainage was performed with the assistance of 23G intraocular illumination. On the first postoperative day, the retina was reattachment and the macrocyst had completely resolved. One month after surgery, the retina was well restored and retinal macrocyst disappeared completely, which was verified by B-ultrasound.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIsolated retinal macrocyst is common in chronic retinal detachment. The extrascleral puncture under intraocular illumination is a selective surgical approach for this entity.\u003c/p\u003e","manuscriptTitle":"A isolated retinal macrocyst secondary to chronic retinal detachment","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-09-01 09:25:25","doi":"10.21203/rs.3.rs-7356123/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"81b2e6b8-ebc6-43fc-bcc6-16eb79baa1e8","owner":[],"postedDate":"September 1st, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-01-06T04:09:28+00:00","versionOfRecord":[],"versionCreatedAt":"2025-09-01 09:25:25","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7356123","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7356123","identity":"rs-7356123","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}