Endovascular Treatment for Acute Basilar Artery Occlusion: A Single Center Retrospective Observational Study

Endovascular Treatment for Acute Basilar Artery Occlusion: A Single Center Retrospective Observational Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Endovascular Treatment for Acute Basilar Artery Occlusion: A Single Center Retrospective Observational Study xuan sun, xu tong, feng gao, huiting lao, zhongrong miao This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.10767/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 06 Dec, 2019 Read the published version in BMC Neurology → Version 2 posted 8 You are reading this latest preprint version Show more versions Abstract Background and purpose: Endovascular treatment (EVT) is now considered the gold standard for select patient populations with anterior circulation stroke; however, data on the treatment of posterior circulation stroke are less clear. This study aims to determine the characteristics and treatment outcomes of patients with acute basilar artery occlusion (BAO) and to evaluate the effectiveness and safety of EVT for patients with acute BAO in a high-volume stroke center. Methods: This study included 187 consecutive patients with acute BAO who underwent EVT from January 2012 to July 2018 in Beijing Tiantan Hospital. The baseline characteristics, procedure parameters, and functional outcome were assessed. Results: Among the 187 patients, 138 (73.8%) underwent mechanical thrombectomy with a stent retriever, 33 (17.6%) underwent direct intracranial angioplasty (balloon dilation and/or stent implantation) for underlying severe intracranial atherosclerotic disease, and 91 (48.7%) underwent combined mechanical thrombectomy and angioplasty. Successful recanalization [modified Thrombolysis in Cerebral Infarction (mTICI) grade 2b-3] was achieved in 158 patients (84.5%). Overall, the rates of functional independence [modified Rankin Scale (mRS) 0-2] and favorable outcome (mRS 0-3) at 90 days were 36.4% and 49.2%, respectively, and 90- day all-cause mortality was 20.3%. Conclusion􀀌􀀁EVT was effective and safe for treating patients with acute BAO. Neurology acute ischemic stroke basilar artery occlusion endovascular treatment Figures Figure 1 Figure 2 Introduction Acute ischemic stroke (AIS) caused by basilar artery occlusion (BAO) has devastating effects on patients and has high morbidity and mortality rates. Among patients treated conventionally with antiplatelets or anticoagulation, the rate of poor outcomes remains high (80%) despite recent advances in stroke care. 1,2 In the registry of Basilar Artery International Cooperation Study (BASICS), 1 the proportion of favorable outcomes [modified Rankin Scale (mRS) 0-3] in the antithrombotic treatment group was 21.9%, 33.9% in the intravenous thrombolysis (IVT) group, and 17.5% in the intra-arterial treatment (local thrombolysis) group. The mortality rates in the groups were 30.6%, 33.9%, and 40.6%, respectively. However, new-generation endovascular treatment (EVT) devices such as “Solitaire” and “Trevo” stent retrievers were not used in the BASICS. 3,4 Modern EVT techniques, particularly mechanical thrombectomy (MT) with stent retrievers, have been validated by several large randomized controlled trials. 5,6 Recently, more studies, including the New England Center Posterior Circulation Registry, have shown a more benign outcome in patients with posterior circulation stroke (PCS) and no significant differences in the clinical features of PCS compared with those with anterior circulation stroke (ACS). 7,8 However, the effectiveness and safety of MT remain uncertain for patients with acute BAO, and few case series and case reports have demonstrated the efficacy and safety of posterior circulation thrombectomy in single-arm studies. We aimed to describe our experience with EVT for acute BAO at a high-volume stroke center in China and to assess its feasibility and safety. Methods 2.1 Patient selection We performed a retrospective analysis of consecutive patients presenting with BAO treated by EVT in Beijing Tiantan Hospital from January 2012 to July 2018. IVT with tissue plasminogen activator (tPA) was acceptable before EVT, consistent with current guidelines. 9 The protocol was approved by the Institutional Review Board of Beijing Tiantan Hospital. Plain computed tomography (CT) of the brain was performed first, followed by either computed tomography angiography (CTA) or magnetic resonance imaging (MRI) with magnetic resonance angiography (MRA) to confirm the presence of acute BAO and to exclude both large brainstem infarction and intracranial bleeding. Imaging modality selection relied on physician preferences and the logistics of scheduling the procedures. We retrospectively analyzed clinical and radiologic data of these patients, including age; sex; stroke risk factors including hypertension, diabetes mellitus, hypercholesterolemia, and current smoking; initial stroke severity as expressed by the National Institutes of Health Stroke Scale (NIHSS) score; initial imaging modality; prior use of IVT; type of EVT devices; onset to puncture time; procedure time; onset to recanalization time; collateral status; and etiology of stroke according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. 10 The modality of treatment was a joint decision between the neurointerventionalist and the stroke team taking care of the patient. 2.2 Endovascular treatment All EVT procedures were performed by a neurointerventionalist with more than 50 cases of experience in neurovascular intervention in MT for AIS. Cerebral angiography and EVT were performed under general anesthesia or conscious sedation after evaluation by a dedicated anesthesiology team. The thrombectomy technique was chosen at the interventionalist’s discretion, using either a stent retriever or aspiration first, with a possible switch to another strategy in case of recanalization failure [modified Thrombolysis in Cerebral Infarction (mTICI) grade 0-2a] with the first approach. If underlying intracranial atherosclerotic stenosis (ICAS) was revealed, intracranial angioplasty or stenting was performed when suitable. Patients undergoing angioplasty and/or stenting received a loading dose of aspirin (300 mg) and clopidogrel (300 mg) orally or via a nasogastric tube immediately after the intervention if they were antiplatelet-naive. Intraoperative bridging with intravenous IIb/IIIa inhibitor was also allowed at the operator’s discretion. Dual antiplatelet therapy was maintained for at least 3 months after the procedure, followed by aspirin or clopidogrel monotherapy lifelong. 2.3 Image interpretation Pretreatment neurovascular images, including posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS), Pons-Midbrain Index based on diffusion-weighted imaging, and two previous collateral scales [posterior communicating artery (PCoa) and American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR)] 11,12 described in the setting of BAO, were retrospectively interpreted by two independent trained neurointerventionalists blinded to clinical data. A third neurointeventionalist with 20 years’ experience was involved to resolve any disputes. All collateral scales mentioned above were evaluated by digital subtraction angiography. 2.4 Outcome measurement Primary effectiveness outcome measures were functional independence and favorable outcome at 90 days after the procedure. Functional independence was defined as an mRS score of ≤ 2. Favorable outcome was defined as an mRS score of ≤ 3, in accordance with the BASICS definition. 1 The mRS was assessed by blinded trained interviewers over the phone using a standardized interview protocol. Other effectiveness outcome measures included the rates of successful recanalization (mTICI 2b-3) and complete recanalization (mTICI = 3). 13 Safety outcome measures were 90-day mortality and rates of intracerebral hemorrhage and symptomatic intracerebral hemorrhage (SICH) within 24 hours. SICH was defined on the basis of the European Cooperative Acute Stroke Study III (ECASS III) criteria. 14 2.5 Statistical analysis Study data were collected on standard forms, evaluated for completeness, and double keyed into an EpiData statistics data document. Baseline and outcome data were described using means (standard deviations) and/or medians (25th and 75th percentiles) for continuous variables. Frequencies and/or proportions were used for categorical variables. Pearson’s chi-square test or Fisher’s exact test was used to compare the differences in frequencies and/or proportions. All tests were two-tailed, and statistical significance was determined at an α level of 0.05. All statistical analyses were performed with the statistical software packages R ( http://www.R-project.org , The R Foundation) and Empowerstats ( http://www.empowerstats.com , X&Y Solutions, Inc., Boston, MA). Data availability statement: All data generated or analyzed during this study are included in this published article [and its supplementary information files]. Results A total of 187 patients with BAO underwent EVT during the study period. Their mean age was 60±10 years, with a median admission NIHSS score of 22 [interquartile range (IQR) 10-34]. Baseline characteristics and procedure and outcome parameters are summarized in Tables 1 and 2. The median time from BAO onset to puncture was 7 hours (IQR 5-10). In terms of procedure parameters, stent retrievers were more frequently used (73.8%) than intra-arterial thrombolysis (23.0%) or stenting (49.7%). General anesthesia was used in 78.6% of the cases, and the median procedure length was 1.5 hours (IQR 1-2). Successful recanalization (mTICI 2b-3) and complete recanalization (mTICI 3) were achieved in 158 (84.5%) and 126 (67.4%) patients, respectively. Intracerebral hemorrhage occurred in 29 (15.5%) patients. SICH within 24 hours occurred in 8 (4.3%) patients. Ninety-day functional independence and favorable outcome were achieved in 68 (36.4%) and 92 (49.2%) patients, respectively, while mortality at 90 days was 20.3% (Table 2). Results from subgroup analysis in patients with acute BAO are shown in Table 3 and Figure 1. Of the 187 patients, 117 (62.6%) had underlying ICAS at the occlusion site. Patients with ICAS and those without ICAS showed similar clinical outcomes. There were no significant differences between the two groups in successful recanalization rate (85.5% versus 82.9%; P=0.63), SICH within 24 hours (3.4% versus 5.7%; P=0.48), functional independence (36.8% versus 35.7%; P=0.89), favorable outcome (53% versus 42.9%; P=0.18) and mortality (17.1% versus 25.7%; P=0.16) at 90 days. Compared with other patients, patients with tandem vertebrobasilar occlusions appeared as a possible predictor of mortality (44.0% versus 16.7%, P=0.01) and had a lower recanalization rate (60.0% versus 88.3%, P0.05). ASITN/SIR collateral scores ≥3 were associated with functional independence (59.1% versus 33.3%, P=0.03) and favorable outcome (77.3% versus 45.5%, P=0.01). Our study demonstrated no difference in successful recanalization, functional independence, and mortality, comparable with results of previous studies from Asian countries. However, our study showed a lower mortality at 90 days compared with that in previous studies from Western countries (Figure 2). Discussion We analyzed the outcome of EVT in patients with BAO at our institution over the past 5 years. In total, 36.4% of the patients had functional independence (mRS 0-2) and 49.2% had a favorable outcome (mRS 0-3) at 90 days, which were comparable with results of the recently published HERMES meta-analysis of EVT for anterior circulation stroke (46% versus 56.9%). 5 Similar findings were also reported in a recent study on 436 patients with acute large vessel occlusion of anterior and posterior circulation treated with EVT. 15 Our findings demonstrate that when patients were carefully selected and appropriately treated with EVT, those with posterior large vessel occlusions can achieve comparable safety and efficacy to those with anterior large vessel occlusions. The patients with BAO in our cohort achieved a similar clinical outcome to those in other Asian studies. 16-19 However, they had a significantly lower mortality (about 20%) than those in studies by Western researchers, 12,20-22 although the enrolled patients in our study had a relatively higher NIHSS score (median=22). This could be explained by the single-center effect attributable to developed interventional techniques and standardized post-operative management. Improving the technology and management of EVT may lead to better recanalization and subsequently to better outcomes. This may also explain why our study had a higher rate of favorable outcomes than previously published studies. 23,24 Our study shows four major findings: First, EVT combined with IVT for BAO failed to show superior outcomes when compared to EVT alone. The issue of whether prior IVT confers a benefit over direct MT alone has not been settled even for patients with anterior circulation, although studies are underway. 25 Second, tandem vertebrobasilar occlusions were associated with poor outcome and higher mortality. However, a previous study showed that patients with tandem lesions who were comparable with those without tandem vertebrobasilar occlusions presented similar clinical outcomes. 26 Only in recent years has occlusion of the vertebral artery origin been more fully characterized and defined as a potential source of embolic stroke and as a potential predictor of mortality in acute BAO. 27 Third, underlying ICAS in the target artery can make the thrombectomy procedure more complicated and require additional rescue treatments such as angioplasty with or without stenting and intra-arterial infusion of antiplatelet drugs. 28 ICAS is an important cause of stent-retriever thrombectomy failure, particularly in Asian patients. 29,30 In our study, 117 patients had underlying ICAS, and 75 underwent intracranial angioplasty (balloon dilation and/or stent implantation) after first-line MT. We achieved similar rates of successful recanalization (85.5% versus 82.9%), functional independence (36.8% versus 35.7%), favorable outcome (53.0% versus 42.9%), SICH (3.4% versus 5.7%), and mortality (17.1% versus 25.7%) to those observed in patients without ICAS. Our study suggests that such rescue treatments are effective and safe for treating underlying ICAS in patients with acute BAO. Finally, the collateral status has been demonstrated to influence recanalization, hemorrhagic transformation, and clinical outcomes in patients with anterior circulation stroke. 31-33 In this series, we used the ASITN/SIR and PCoA scales to assess the collateral status and found a significant correlation between ASITN/SIR and 90-day outcomes, but PCoA collaterals were not significantly associated with clinical outcome. Our study has several limitations. It was a retrospective, non-randomized controlled study. Data were obtained from a single high-volume stroke center with an interventionalist highly experienced in performing the procedure, so the results may not be replicable in other lower-volume stroke centers. However, the strength of our study is that it represents one of the largest cohorts of patients with BAO treated with EVT. The broad inclusion criteria from stroke severity and time of presentation and variability in procedure parameters allow us to improve our understanding of the specific needs of this patient population and appropriate therapeutic strategies. Future multicenter studies are needed to validate our findings. Conclusion Although there is a lack of data from randomized clinical trials to establish the best treatment for BAO, the present study suggests that EVT for patients with BAO should be reasonable in the modern era. Abbreviations endovascular treatment (EVT); basilar artery occlusion (BAO); modified Thrombolysis in Cerebral Infarction (mTICI); modified Rankin Scale (mRS); acute ischemic stroke (AIS); intravenous thrombolysis (IVT); endovascular treatment (EVT); mechanical thrombectomy (MT); posterior circulation stroke (PCS); anterior circulation stroke (ACS); tissue plasminogen activator (tPA); computed tomography (CT); computed tomography angiography (CTA); magnetic resonance imaging (MRI); magnetic resonance angiography (MRA); National Institutes of Health Stroke Scale (NIHSS); intracranial atherosclerotic stenosis (ICAS); Prognosis Early CT Score (pc-ASPECTS); symptomatic intracerebral hemorrhage (SICH); interquartile range (IQR) Declarations Ethics approval The protocol was approved by the Institutional Review Board of Beijing Tiantan Hospital. Consent to publish Not applicable. Availability of data and material All data generated or analysed during this study are included in this published article [and its supplementary information files] Competing interests The authors declare no conflict of interest. Sources of Funding This study was funded by the National Key Research and Development Program of China; (2016YFC1301501). Z.M designed research, collection, analysis, and interpretation of data. Authors' contributions X.S. and Z.M. designed research; X.S., X.T., F.G. and H.L. collection and interpretation of data; Z.M. wrote the manuscript and approved the submitted version. Acknowledgments We thank all relevant clinicians, statistician, and imaging technicians. References Schonewille WJ, Wijman CA, Michel P, Rueckert CM, Weimar C, Mattle HP, Engelter ST, Tanne D, Muir KW, Molina CA, Thijs V, Audebert H, Pfefferkorn T, Szabo K, Lindsberg PJ, de Freitas G, Kappelle LJ, Algra A, BASICS study group. 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Variable name Overall cohort (n=187) Demographic data Age, mean (SD), years 60 (10) Male sex 157 (84.0) Vascular risk factors Hypertension 133 (71.1) Diabetes mellitus 51 (27.3) Dyslipidemia 30 (16.0) Coronary heart disease 21 (11.2) Atrial fibrillation 11 (5.9) Prior stroke 37 (19.8) Premorbid mRS ≥ 3 9 (4.8) Current smoking 70 (37.4) Clinical characteristics SBP, mean (SD), mmHg 160 (25) NIHSS score, median (IQR) 22 (10-34) GCS score, median (IQR) 8 (3-13) pc-ASPECTS on DWI, median (IQR) 6 (5-8) PMI on DWI, median (IQR) 2 (1-4) Occlusion site Proximal BA (including intracranial VA) 104 (55.6) Middle BA 54 (28.9) Distal BA 29 (15.5) Tandem lesion 25 (13.4) Underlying ICAS 117 (62.6) Presence of PcomA No 68 (36.4) Unilateral 88 (47.1) Bilateral 31 (16.6) ASITN/SIR collateral system Grade 0-1 78 (41.7) Grade 2 87 (46.5) Grade 3-4 22 (11.8) Stroke subtype by TOAST criteria Large artery arteriosclerosis 151 (80.7) Cardioembolic 29 (15.5) Other or unknown etiology 7 (3.7) Table 2. Variable name Overall cohort (n=187) Procedural features Prior use of intravenous tPA 36 (19.3) General anaesthesia 147 (78.6) Use of Solitaire retriever 138 (73.8) No. of passes ≤ 1 70 (50.7) 2 38 (27.5) ≥ 3 30 (21.7) Intra-arterial tPA or Urokinase 43 (23.0) Balloon angioplasty 101 (54.0) Stenting 93 (49.7) Onset to puncture time, median (IQR), hours 7 (5-10) Procedure time, median (IQR), hours 1.5 (1-2) Onset to recanalization time, median (IQR), hours 8.5 (6-11) Procedural complications Embolization in distal or new territory 18 (9.6) Arterial dissection 6 (3.2) Arterial perforation 8 (4.3) Target-vessel reocclusion 17 (9.1) Outcome measures Successful recanalization (mTICI 2b-3) 158 (84.5) Complete recanalization (mTICI 3) 126 (67.4) Hemorrhagic transformation within 24 hours 29 (15.5) SICH (ECASS III definition) within 24 hours 8 (4.3) Functional independence (mRS 0-2) at 90 days 68 (36.4) Favorable outcome (mRS 0-3) at 90 days 92 (49.2) Mortality at 90 days 38 (20.3) Table 3. Outcome variables Subgroups Tandem lesion ICAS ASITN/SIR collateral system Prior use of intravenous tPA Yes (n=25) No (n=162) P value Yes (n=117) No (n=70) P value Grade 0-2 (n=165) Grade 3-4 (n=22) P value Yes (n=36) No (n=151) P value Successful recanalization (mTICI 2b-3) 15 (60.0) 143 (88.3) < 0.01 100 (85.5) 58 (82.9) 0.63 137 (83.0) 21 (95.5) 0.21 30 (83.3) 128 (84.8) 0.80 Complete recanalization (mTICI 3) 13 (52.0) 113 (69.8) 0.11 77 (65.8) 49 (70.0) 0.55 108 (65.5) 18 (81.8) 0.15 26 (72.2) 100 (66.2) 0.49 Hemorrhagic transformation within 24 hours 4 (16.0) 25 (15.4) > 0.99 16 (13.7) 13 (18.6) 0.37 26 (15.8) 3 (13.6) > 0.99 7 (19.4) 22 (14.6) 0.45 SICH (ECASS III definition) within 24 hours 2 (8.0) 6 (3.7) 0.29 4 (3.4) 4 (5.7) 0.48 7 (4.2) 1 (4.6) > 0.99 1 (2.8) 7 (4.6) > 0.99 Functional independence (mRS 0-2) at 90 days 7 (28.0) 61 (37.7) 0.38 43 (36.8) 25 (35.7) 0.89 55 (33.3) 13 (59.1) 0.03 15 (41.7) 53 (35.1) 0.46 Favorable outcome (mRS 0-3) at 90 days 8 (32.0) 84 (51.9) 0.07 62 (53.0) 30 (42.9) 0.18 75 (45.5) 17 (77.3) 0.01 19 (52.8) 73 (48.3) 0.63 Mortality at 90 days 11 (44.0) 27 (16.7) 0.01 20 (17.1) 18 (25.7) 0.16 36 (21.8) 2 (9.1) 0.26 6 (16.7) 32 (21.2) 0.65 Additional File Additional file 1: Raw Data. Supplementary Files Supplementarydata.pdf RawData.xlsx Cite Share Download PDF Status: Published Journal Publication published 06 Dec, 2019 Read the published version in BMC Neurology → Version 2 posted Editorial decision: Minor revision 21 Nov, 2019 Review # 1 received at journal 16 Oct, 2019 Reviewer # 2 agreed at journal 15 Oct, 2019 Reviewer # 1 agreed at journal 01 Oct, 2019 Editor assigned by journal 30 Sep, 2019 Reviewers invited by journal 30 Sep, 2019 Submission checks completed at journal 29 Sep, 2019 Editor invited by journal 29 Sep, 2019 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1713","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":175796,"identity":"0dc9ab7e-328a-4f79-a3cd-d2a6d1e40967","order_by":1,"name":"xuan sun","email":"","orcid":"","institution":"Beijing Tiantan hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"xuan","middleName":"","lastName":"sun","suffix":""},{"id":175797,"identity":"1b5c5886-29a0-4c5b-8f82-7b3e17583df7","order_by":2,"name":"xu tong","email":"","orcid":"","institution":"Beijing Tiantan hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"xu","middleName":"","lastName":"tong","suffix":""},{"id":175798,"identity":"5831ff9a-9afb-48bd-aff7-8542c21c6db3","order_by":3,"name":"feng gao","email":"","orcid":"","institution":"Beijing Tiantan hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"feng","middleName":"","lastName":"gao","suffix":""},{"id":175799,"identity":"705c5b4b-56ef-4ea9-8f6e-b41c8cc11dd5","order_by":4,"name":"huiting lao","email":"","orcid":"","institution":"Queen Elizabeth hôpital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"huiting","middleName":"","lastName":"lao","suffix":""},{"id":175800,"identity":"bd891952-f60b-4ef0-bcdf-3722230217d0","order_by":5,"name":"zhongrong miao","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABBklEQVRIiWNgGAWjYDACZiBmbIDxDGzs+JmZDz4gQUtBWrJkO1uyAUGbEFo+HGbccJ7HTACfat125ocPf+6wyZOPPnzs4RcDZmbjwwxmDAw1NtG4tJgdZjM2kDyTVmx4Li3dWMaAjc/sMEPaA4ZjabkNOLUwmEkYth1O3NjDYyYtYcDDDBQ5bsDYcBiPFvZvEokILRKMm5sZ2yTwa+ExkzgI1DKfh8dM8oOBAeMGZmY2QlqKDRvb0hI38LClSTMYJCRLHGZjNkjA55fzxzc+/Nlmkzi/h/mY5I8//+34+89/fPChxganFjgwOACMVh4YL4GQchCQBxrK+IMYlaNgFIyCUTDiAAAuCFf9++KfowAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0002-0974-3594","institution":"Beijing Tiantan hospial","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"zhongrong","middleName":"","lastName":"miao","suffix":""}],"badges":[],"createdAt":"2019-06-26 15:16:37","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.2.10767/v2","doiUrl":"https://doi.org/10.21203/rs.2.10767/v2","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12883-019-1551-8","type":"published","date":"2019-12-06T12:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":112998,"identity":"a7a65390-11c6-42a6-8e94-a4d6419adbe0","added_by":"auto","created_at":"2019-10-07 14:09:35","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":112521,"visible":true,"origin":"","legend":"The Distribution of 90-Day mRS in ABAO Patients with Different Subgroup","description":"","filename":"Figure11.png","url":"https://assets-eu.researchsquare.com/files/845e900b-1749-4b58-8d0a-9960f96cc393/v2/Figure1[1].png"},{"id":113002,"identity":"9d1fba80-de2a-4b6f-95b0-5aefc8fc0228","added_by":"auto","created_at":"2019-10-07 14:09:36","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":125278,"visible":true,"origin":"","legend":"The clinical outcome compared with other Asian and western studies","description":"","filename":"Figure21.png","url":"https://assets-eu.researchsquare.com/files/845e900b-1749-4b58-8d0a-9960f96cc393/v2/Figure2[1].png"},{"id":13475918,"identity":"65475df9-0305-42a9-8271-a08d9ce015f1","added_by":"auto","created_at":"2021-09-16 21:26:34","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":546355,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1713/v2/0ac698f3-3909-4416-8282-82d224fc3156.pdf"},{"id":113001,"identity":"7af740c7-2a78-4af8-997a-3acdfa0a21b7","added_by":"auto","created_at":"2019-10-07 14:09:36","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":297868,"visible":true,"origin":"","legend":"","description":"","filename":"Supplementarydata.pdf","url":"https://assets-eu.researchsquare.com/files/845e900b-1749-4b58-8d0a-9960f96cc393/v2/Supplementary data.pdf"},{"id":113000,"identity":"8713c48d-8ef2-4f21-81fd-3bfbf208f791","added_by":"auto","created_at":"2019-10-07 14:09:35","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":322028,"visible":true,"origin":"","legend":"","description":"","filename":"RawData.xlsx","url":"https://assets-eu.researchsquare.com/files/845e900b-1749-4b58-8d0a-9960f96cc393/v2/Raw Data.xlsx"}],"financialInterests":"","formattedTitle":"Endovascular Treatment for Acute Basilar Artery Occlusion: A Single Center Retrospective Observational Study","fulltext":[{"header":"Introduction","content":"\u003cp\u003eAcute ischemic stroke (AIS) caused by basilar artery occlusion (BAO) has devastating effects on patients and has high morbidity and mortality rates. Among patients treated conventionally with antiplatelets or anticoagulation, the rate of poor outcomes remains high (80%) despite recent advances in stroke care.\u003csup\u003e1,2\u003c/sup\u003e In the registry of Basilar Artery International Cooperation Study (BASICS),\u003csup\u003e1\u003c/sup\u003e the proportion of favorable outcomes [modified Rankin Scale (mRS) 0-3] in the antithrombotic treatment group was 21.9%, 33.9% in the intravenous thrombolysis (IVT) group, and 17.5% in the intra-arterial treatment (local thrombolysis) group. The mortality rates in the groups were 30.6%, 33.9%, and 40.6%, respectively. However, new-generation endovascular treatment (EVT) devices such as \u0026ldquo;Solitaire\u0026rdquo; and \u0026ldquo;Trevo\u0026rdquo; stent retrievers were not used in the BASICS.\u003csup\u003e3,4\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eModern EVT techniques, particularly mechanical thrombectomy (MT) with stent retrievers, have been validated by several large randomized controlled trials.\u003csup\u003e5,6\u003c/sup\u003e Recently, more studies, including the New England Center Posterior Circulation Registry, have shown a more benign outcome in patients with posterior circulation stroke (PCS) and no significant differences in the clinical features of PCS compared with those with anterior circulation stroke (ACS).\u003csup\u003e7,8\u003c/sup\u003e However, the effectiveness and safety of MT remain uncertain for patients with acute BAO, and few case series and case reports have demonstrated the efficacy and safety of posterior circulation thrombectomy in single-arm studies. We aimed to describe our experience with EVT for acute BAO at a high-volume stroke center in China and to assess its feasibility and safety.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003e2.1 Patient selection\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe performed a retrospective analysis of consecutive patients presenting with BAO treated by EVT in Beijing Tiantan Hospital from January 2012 to July 2018. IVT with tissue plasminogen activator (tPA) was acceptable before EVT, consistent with current guidelines.\u003csup\u003e9\u003c/sup\u003e The protocol was approved by the Institutional Review Board of Beijing Tiantan Hospital.\u003c/p\u003e\n\u003cp\u003ePlain computed tomography (CT) of the brain was performed first, followed by either computed tomography angiography (CTA) or magnetic resonance imaging (MRI) with magnetic resonance angiography (MRA) to confirm the presence of acute BAO and to exclude both large brainstem infarction and intracranial bleeding. Imaging modality selection relied on physician preferences and the logistics of scheduling the procedures. We retrospectively analyzed clinical and radiologic data of these patients, including age; sex; stroke risk factors including hypertension, diabetes mellitus, hypercholesterolemia, and current smoking; initial stroke severity as expressed by the National Institutes of Health Stroke Scale (NIHSS) score; initial imaging modality; prior use of IVT; type of EVT devices; onset to puncture time; procedure time; onset to recanalization time; collateral status; and etiology of stroke according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification.\u003csup\u003e10\u003c/sup\u003e The modality of treatment was a joint decision between the neurointerventionalist and the stroke team taking care of the patient.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.2 Endovascular treatment\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll EVT procedures were performed by a neurointerventionalist with more than 50 cases of experience in neurovascular intervention in MT for AIS. Cerebral angiography and EVT were performed under general anesthesia or conscious sedation after evaluation by a dedicated anesthesiology team. The thrombectomy technique was chosen at the interventionalist\u0026rsquo;s discretion, using either a stent retriever or aspiration first, with a possible switch to another strategy in case of recanalization failure [modified Thrombolysis in Cerebral Infarction (mTICI) grade 0-2a] with the first approach. If underlying intracranial atherosclerotic stenosis (ICAS) was revealed, intracranial angioplasty or stenting was performed when suitable. Patients undergoing angioplasty and/or stenting received a loading dose of aspirin (300 mg) and clopidogrel (300 mg) orally or via a nasogastric tube immediately after the intervention if they were antiplatelet-naive. Intraoperative bridging with intravenous IIb/IIIa inhibitor was also allowed at the operator\u0026rsquo;s discretion. Dual antiplatelet therapy was maintained for at least 3 months after the procedure, followed by aspirin or clopidogrel monotherapy lifelong.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.3 Image interpretation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePretreatment neurovascular images, including posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS), Pons-Midbrain Index based on diffusion-weighted imaging, and two previous collateral scales [posterior communicating artery (PCoa) and American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR)]\u003csup\u003e11,12\u003c/sup\u003e described in the setting of BAO, were retrospectively interpreted by two independent trained neurointerventionalists blinded to clinical data. A third neurointeventionalist with 20 years\u0026rsquo; experience was involved to resolve any disputes. All collateral scales mentioned above were evaluated by digital subtraction angiography.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.4 Outcome measurement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePrimary effectiveness outcome measures were functional independence and favorable outcome at 90 days after the procedure. Functional independence was defined as an mRS score of \u0026le; 2. Favorable outcome was defined as an mRS score of \u0026le; 3, in accordance with the BASICS definition.\u003csup\u003e1\u003c/sup\u003e The mRS was assessed by blinded trained interviewers over the phone using a standardized interview protocol. Other effectiveness outcome measures included the rates of successful recanalization (mTICI 2b-3) and complete recanalization (mTICI = 3).\u003csup\u003e13\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eSafety outcome measures were 90-day mortality and rates of intracerebral hemorrhage and symptomatic intracerebral hemorrhage (SICH) within 24 hours. SICH was defined on the basis of the European Cooperative Acute Stroke Study III (ECASS III) criteria.\u003csup\u003e14\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.5 Statistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eStudy data were collected on standard forms, evaluated for completeness, and double keyed into an EpiData statistics data document. Baseline and outcome data were described using means (standard deviations) and/or medians (25th and 75th percentiles) for continuous variables. Frequencies and/or proportions were used for categorical variables. Pearson\u0026rsquo;s chi-square test or Fisher\u0026rsquo;s exact test was used to compare the differences in frequencies and/or proportions. All tests were two-tailed, and statistical significance was determined at an \u0026alpha; level of 0.05. All statistical analyses were performed with the statistical software packages R (\u003ca href=\"http://www.R-project.org\"\u003ehttp://www.R-project.org\u003c/a\u003e, The R Foundation) and Empowerstats (\u003ca href=\"http://www.empowerstats.com\"\u003ehttp://www.empowerstats.com\u003c/a\u003e, X\u0026amp;Y Solutions, Inc., Boston, MA).\u003c/p\u003e\n\u003cp\u003eData availability statement: All data generated or analyzed during this study are included in this published article [and its supplementary information files].\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eA total of 187 patients with BAO underwent EVT during the study period. Their mean age was 60\u0026plusmn;10 years, with a median admission NIHSS score of 22 [interquartile range (IQR) 10-34]. Baseline characteristics and procedure and outcome parameters are summarized in Tables 1 and 2. The median time from BAO onset to puncture was 7 hours (IQR 5-10). In terms of procedure parameters, stent retrievers were more frequently used (73.8%) than intra-arterial thrombolysis (23.0%) or stenting (49.7%). General anesthesia was used in 78.6% of the cases, and the median procedure length was 1.5 hours (IQR 1-2). Successful recanalization (mTICI 2b-3) and complete recanalization (mTICI 3) were achieved in 158 (84.5%) and 126 (67.4%) patients, respectively. Intracerebral hemorrhage occurred in 29 (15.5%) patients. SICH within 24 hours occurred in 8 (4.3%) patients. Ninety-day functional independence and favorable outcome were achieved in 68 (36.4%) and 92 (49.2%) patients, respectively, while mortality at 90 days was 20.3% (Table 2).\u003c/p\u003e\n\u003cp\u003eResults from subgroup analysis in patients with acute BAO are shown in Table 3 and Figure 1. Of the 187 patients, 117 (62.6%) had underlying ICAS at the occlusion site. Patients with ICAS and those without ICAS showed similar clinical outcomes. There were no significant differences between the two groups in successful recanalization rate (85.5% versus 82.9%; P=0.63), SICH within 24 hours (3.4% versus 5.7%; P=0.48), functional independence (36.8% versus 35.7%; P=0.89), favorable outcome (53% versus 42.9%; P=0.18) and mortality (17.1% versus 25.7%; P=0.16) at 90 days. Compared with other patients, patients with tandem vertebrobasilar occlusions appeared as a possible predictor of mortality (44.0% versus 16.7%, P=0.01) and had a lower recanalization rate (60.0% versus 88.3%, P\u0026lt;0.01). No differences in effectiveness and safety outcomes were observed in patients with or without prior use of intravenous tPA (P\u0026gt;0.05). ASITN/SIR collateral scores \u0026ge;3 were associated with functional independence (59.1% versus 33.3%, P=0.03) and favorable outcome (77.3% versus 45.5%, P=0.01). Our study demonstrated no difference in successful recanalization, functional independence, and mortality, comparable with results of previous studies from Asian countries. However, our study showed a lower mortality at 90 days compared with that in previous studies from Western countries (Figure 2).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eWe analyzed the outcome of EVT in patients with BAO at our institution over the past 5 years. In total, 36.4% of the patients had functional independence (mRS 0-2) and 49.2% had a favorable outcome (mRS 0-3) at 90 days, which were comparable with results of the recently published HERMES meta-analysis of EVT for anterior circulation stroke (46% versus 56.9%).\u003csup\u003e5\u003c/sup\u003e Similar findings were also reported in a recent study on 436 patients with acute large vessel occlusion of anterior and posterior circulation treated with EVT.\u003csup\u003e15\u003c/sup\u003e Our findings demonstrate that when patients were carefully selected and appropriately treated with EVT, those with posterior large vessel occlusions can achieve comparable safety and efficacy to those with anterior large vessel occlusions. The patients with BAO in our cohort achieved a similar clinical outcome to those in other Asian studies.\u003csup\u003e16-19\u003c/sup\u003e However, they had a significantly lower mortality (about 20%) than those in studies by Western researchers,\u003csup\u003e12,20-22\u003c/sup\u003e although the enrolled patients in our study had a relatively higher NIHSS score (median=22). This could be explained by the single-center effect attributable to developed interventional techniques and standardized post-operative management. Improving the technology and management of EVT may lead to better recanalization and subsequently to better outcomes. This may also explain why our study had a higher rate of favorable outcomes than previously published studies.\u003csup\u003e23,24\u003c/sup\u003e\u003c/p\u003e\n\u003cp\u003eOur study shows four major findings: First, EVT combined with IVT for BAO failed to show superior outcomes when compared to EVT alone. The issue of whether prior IVT confers a benefit over direct MT alone has not been settled even for patients with anterior circulation, although studies are underway.\u003csup\u003e25\u003c/sup\u003e Second, tandem vertebrobasilar occlusions were associated with poor outcome and higher mortality. However, a previous study showed that patients with tandem lesions who were comparable with those without tandem vertebrobasilar occlusions presented similar clinical outcomes.\u003csup\u003e26\u003c/sup\u003e Only in recent years has occlusion of the vertebral artery origin been more fully characterized and defined as a potential source of embolic stroke and as a potential predictor of mortality in acute BAO.\u003csup\u003e27\u003c/sup\u003e Third, underlying ICAS in the target artery can make the thrombectomy procedure more complicated and require additional rescue treatments such as angioplasty with or without stenting and intra-arterial infusion of antiplatelet drugs.\u003csup\u003e28\u003c/sup\u003e ICAS is an important cause of stent-retriever thrombectomy failure, particularly in Asian patients.\u003csup\u003e29,30\u003c/sup\u003e In our study, 117 patients had underlying ICAS, and 75 underwent intracranial angioplasty (balloon dilation and/or stent implantation) after first-line MT. We achieved similar rates of successful recanalization (85.5% versus 82.9%), functional independence (36.8% versus 35.7%), favorable outcome (53.0% versus 42.9%), SICH (3.4% versus 5.7%), and mortality (17.1% versus 25.7%) to those observed in patients without ICAS. Our study suggests that such rescue treatments are effective and safe for treating underlying ICAS in patients with acute BAO. Finally, the collateral status has been demonstrated to influence recanalization, hemorrhagic transformation, and clinical outcomes in patients with anterior circulation stroke.\u003csup\u003e31-33\u003c/sup\u003e In this series, we used the ASITN/SIR and PCoA scales to assess the collateral status and found a significant correlation between ASITN/SIR and 90-day outcomes, but PCoA collaterals were not significantly associated with clinical outcome.\u003c/p\u003e\n\u003cp\u003eOur study has several limitations. It was a retrospective, non-randomized controlled study. Data were obtained from a single high-volume stroke center with an interventionalist highly experienced in performing the procedure, so the results may not be replicable in other lower-volume stroke centers. However, the strength of our study is that it represents one of the largest cohorts of patients with BAO treated with EVT. The broad inclusion criteria from stroke severity and time of presentation and variability in procedure parameters allow us to improve our understanding of the specific needs of this patient population and appropriate therapeutic strategies. Future multicenter studies are needed to validate our findings.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eAlthough there is a lack of data from randomized clinical trials to establish the best treatment for BAO, the present study suggests that EVT for patients with BAO should be reasonable in the modern era.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eendovascular treatment (EVT); basilar artery occlusion (BAO); modified Thrombolysis in Cerebral Infarction (mTICI); modified Rankin Scale (mRS); acute ischemic stroke (AIS); intravenous thrombolysis (IVT); endovascular treatment (EVT); mechanical thrombectomy (MT); posterior circulation stroke (PCS); anterior circulation stroke (ACS); tissue plasminogen activator (tPA); computed tomography (CT); computed tomography angiography (CTA); magnetic resonance imaging (MRI); magnetic resonance angiography (MRA); National Institutes of Health Stroke Scale (NIHSS); intracranial atherosclerotic stenosis (ICAS); Prognosis Early CT Score (pc-ASPECTS); symptomatic intracerebral hemorrhage (SICH); interquartile range (IQR)\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe protocol was approved by the Institutional Review Board of Beijing Tiantan Hospital.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to publish\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data generated or analysed during this study are included in this published article [and its supplementary information files]\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSources of Funding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was funded by the National Key Research and Development Program of China; (2016YFC1301501).\u003c/p\u003e\n\u003cp\u003eZ.M designed research, collection, analysis, and interpretation of data.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eX.S. and Z.M. designed research; X.S., X.T., F.G. and H.L. collection and interpretation of data; Z.M. wrote the manuscript and approved the submitted version.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe thank all relevant clinicians, statistician, and imaging technicians.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eSchonewille WJ, Wijman CA, Michel P, Rueckert CM, Weimar C, Mattle HP, Engelter ST, Tanne D, Muir KW, Molina CA, Thijs V, Audebert H, Pfefferkorn T, Szabo K, Lindsberg PJ, de Freitas G, Kappelle LJ, Algra A, BASICS study group. 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Pretreatment ipsilateral regional cortical blood flow influences vessel recanalization in intra-arterial thrombolysis for MCA occlusion. \u003cem\u003eAJNR Am J Neuroradiol\u003c/em\u003e. 2007;28:164-7.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eTable 1.\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 423pt; border-collapse: collapse; border: none; height: 529px;\" width=\"564\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 25.5pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 25px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eVariable name\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 25px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eOverall cohort (n=187)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eDemographic data\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; 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font-family: verdana, geneva;\"\u003e157 (84.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eVascular risk factors\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eHypertension\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e133 (71.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eDiabetes mellitus\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e51 (27.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eDyslipidemia\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e30 (16.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eCoronary heart disease\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e21 (11.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eAtrial fibrillation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e11 (5.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003ePrior stroke\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e37 (19.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003ePremorbid mRS \u0026ge; 3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e9 (4.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eCurrent smoking\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e70 (37.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eClinical characteristics\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eSBP, mean (SD), mmHg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e160 (25)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eNIHSS score, median (IQR)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e22 (10-34)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eGCS score, median (IQR)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e8 (3-13)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003epc-ASPECTS on DWI, median (IQR)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e6 (5-8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003ePMI on DWI, median (IQR)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e2 (1-4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eOcclusion site\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eProximal BA (including intracranial VA)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e104 (55.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eMiddle BA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e54 (28.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eDistal BA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e29 (15.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eTandem lesion\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e25 (13.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eUnderlying ICAS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e117 (62.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003ePresence of PcomA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e68 (36.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eUnilateral\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e88 (47.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eBilateral\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e31 (16.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eASITN/SIR collateral system\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp; Grade 0-1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e78 (41.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp; Grade 2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e87 (46.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp; Grade 3-4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e22 (11.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eStroke subtype by TOAST criteria\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eLarge artery arteriosclerosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e151 (80.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eCardioembolic\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border: none; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e29 (15.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 321.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eOther or unknown etiology\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 213.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 14px;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e7 (3.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin-right: -.05pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eTable 2. \u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 423.0pt; border-collapse: collapse; border: none;\" width=\"564\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 25.5pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 25.5pt;\" width=\"338\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eVariable name\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 25.5pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eOverall cohort (n=187)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eProcedural features\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003ePrior use of intravenous tPA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e36 (19.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eGeneral anaesthesia\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e147 (78.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eUse of Solitaire retriever\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e138 (73.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eNo. of passes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp; \u0026le; 1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e70 (50.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp; 2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e38 (27.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp; \u0026ge; 3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e30 (21.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eIntra-arterial tPA or Urokinase\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e43 (23.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eBalloon angioplasty\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e101 (54.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eStenting\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e93 (49.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eOnset to puncture time, median (IQR), hours\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e7 (5-10)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eProcedure time, median (IQR), hours\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e1.5 (1-2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eOnset to recanalization time, median (IQR), hours\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e8.5 (6-11)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eProcedural complications\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eEmbolization in distal or new territory\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e18 (9.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eArterial dissection\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e6 (3.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eArterial perforation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e8 (4.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: .25in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eTarget-vessel reocclusion\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e17 (9.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eOutcome measures\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eSuccessful recanalization (mTICI 2b-3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e158 (84.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eComplete recanalization (mTICI 3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e126 (67.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eHemorrhagic transformation within 24 hours\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e29 (15.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eSICH (ECASS III definition) within 24 hours\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e8 (4.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eFunctional independence (mRS 0-2) at 90 days\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e68 (36.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eFavorable outcome (mRS 0-3) at 90 days\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e92 (49.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.2pt;\"\u003e\n\u003ctd style=\"width: 253.25pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"338\"\u003e\n\u003cp style=\"text-indent: 9.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eMortality at 90 days\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 169.75pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.2pt;\" width=\"226\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e38 (20.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin-right: -.05pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eTable 3. \u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 750.75pt; border-collapse: collapse; border: none;\" width=\"1001\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 151.65pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" rowspan=\"3\" width=\"202\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eOutcome variables\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 599.1pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" colspan=\"15\" width=\"799\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eSubgroups\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 133.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" colspan=\"3\" width=\"178\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eTandem lesion\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.45pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"11\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" colspan=\"3\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eICAS\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.1pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 173.25pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" colspan=\"3\" width=\"231\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003eASITN/SIR collateral system\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 6.7pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 135.45pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" colspan=\"3\" width=\"181\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003ePrior use of intravenous tPA\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 48.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eYes (n=25)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.15pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eNo (n=162)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 36.9pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"49\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eP value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"11\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eYes (n=117)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eNo (n=70)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eP value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.1pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66.25pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"88\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eGrade 0-2 (n=165)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.6pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eGrade 3-4 (n=22)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eP value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 6.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.65pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eYes (n=36)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.0pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eNo (n=151)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eP value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 151.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"202\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eSuccessful recanalization (mTICI 2b-3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e15 (60.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.15pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e143 (88.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 36.9pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"49\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026lt; 0.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"11\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e100 (85.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e58 (82.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.1pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66.25pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"88\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e137 (83.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e21 (95.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 6.7pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e30 (83.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.0pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e128 (84.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 151.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"202\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eComplete recanalization (mTICI 3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e13 (52.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.15pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e113 (69.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 36.9pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"49\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"11\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e77 (65.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e49 (70.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.55\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.1pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66.25pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"88\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e108 (65.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e18 (81.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.15\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 6.7pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e26 (72.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.0pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e100 (66.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 151.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"202\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eHemorrhagic transformation within 24 hours\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e4 (16.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.15pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e25 (15.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 36.9pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"49\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026gt; 0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"11\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e16 (13.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e13 (18.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.37\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.1pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66.25pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"88\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e26 (15.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e3 (13.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026gt; 0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 6.7pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e7 (19.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.0pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e22 (14.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.45\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 151.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"202\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eSICH (ECASS III definition) within 24 hours\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e2 (8.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.15pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e6 (3.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 36.9pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"49\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.29\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"11\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e4 (3.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e4 (5.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.48\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.1pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66.25pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"88\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e7 (4.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e1 (4.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026gt; 0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 6.7pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e1 (2.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.0pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e7 (4.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026gt; 0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 151.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"202\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eFunctional independence (mRS 0-2) at 90 days\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e7 (28.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.15pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e61 (37.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 36.9pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"49\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.38\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"11\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e43 (36.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e25 (35.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.89\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.1pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66.25pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"88\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e55 (33.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e13 (59.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 6.7pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e15 (41.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.0pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e53 (35.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.46\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 151.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"202\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eFavorable outcome (mRS 0-3) at 90 days\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e8 (32.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.15pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e84 (51.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 36.9pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"49\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.07\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"11\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e62 (53.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e30 (42.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.18\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.1pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66.25pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"88\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e75 (45.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.6pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e17 (77.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 6.7pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"9\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.65pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e19 (52.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.0pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e73 (48.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 21.25pt;\"\u003e\n\u003ctd style=\"width: 151.65pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"202\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003eMortality at 90 days\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"65\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e11 (44.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 2.85pt 0in 2.85pt; height: 21.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; 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height: 21.25pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e0.65\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Additional File","content":"\u003cp\u003eAdditional file 1: Raw Data.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-neurology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"nurl","sideBox":"Learn more about [BMC Neurology](http://bmcneurol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/nurl","title":"BMC Neurology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"acute ischemic stroke, basilar artery occlusion, endovascular treatment","lastPublishedDoi":"10.21203/rs.2.10767/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.10767/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Background and purpose: Endovascular treatment (EVT) is now considered the gold standard for select patient populations with anterior circulation stroke; however, data on the treatment of posterior circulation stroke are less clear. This study aims to determine the characteristics and treatment outcomes of patients with acute basilar artery occlusion (BAO) and to evaluate the effectiveness and safety of EVT for patients with acute BAO in a high-volume stroke center. Methods: This study included 187 consecutive patients with acute BAO who underwent EVT from January 2012 to July 2018 in Beijing Tiantan Hospital. The baseline characteristics, procedure parameters, and functional outcome were assessed. Results: Among the 187 patients, 138 (73.8%) underwent mechanical thrombectomy with a stent retriever, 33 (17.6%) underwent direct intracranial angioplasty (balloon dilation and/or stent implantation) for underlying severe intracranial atherosclerotic disease, and 91 (48.7%) underwent combined mechanical thrombectomy and angioplasty. Successful recanalization [modified Thrombolysis in Cerebral Infarction (mTICI) grade 2b-3] was achieved in 158 patients (84.5%). Overall, the rates of functional independence [modified Rankin Scale (mRS) 0-2] and favorable outcome (mRS 0-3) at 90 days were 36.4% and 49.2%, respectively, and 90- day all-cause mortality was 20.3%. Conclusion􀀌􀀁EVT was effective and safe for treating patients with acute BAO.","manuscriptTitle":"Endovascular Treatment for Acute Basilar Artery Occlusion: A Single Center Retrospective Observational Study","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2019-10-07 14:09:35","doi":"10.21203/rs.2.10767/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2019-11-21T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2019-10-16T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests.**\n\nComments to Author:\n---\n"},{"type":"reviewerAgreed","content":"","date":"2019-10-15T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-10-01T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2019-09-30T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewersInvited","content":"","date":"2019-09-30T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2019-09-29T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-09-29T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-neurology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"nurl","sideBox":"Learn more about [BMC Neurology](http://bmcneurol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/nurl","title":"BMC Neurology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2019-06-27 22:37:18","doi":"10.21203/rs.2.10767/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2019-09-10T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2019-07-26T12:00:00+00:00","index":2,"fulltext":"Form responses:\n---\n* Does the work include the necessary controls?\nIf not, please specify which controls are required in your comments to the authors.\tNo: **Are the conclusions drawn adequately supported by the data shown?\nIf not, please explain in your comments to the authors.\tYes**\n"},{"type":"editorInvitedReview","content":"","date":"2019-07-26T12:00:00+00:00","index":1,"fulltext":"Form responses:\n---\n* Does the work include the necessary controls?\nIf not, please specify which controls are required in your comments to the authors.\tNo: **Are the conclusions drawn adequately supported by the data shown?\nIf not, please explain in your comments to the authors.\tYes**\n"},{"type":"reviewerAgreed","content":"","date":"2019-07-14T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2019-07-10T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-07-10T12:00:00+00:00","index":1,"fulltext":""},{"type":"checksComplete","content":"","date":"2019-06-16T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-06-16T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2019-06-16T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-neurology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"nurl","sideBox":"Learn more about [BMC Neurology](http://bmcneurol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/nurl","title":"BMC Neurology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"60314f9f-8984-4d34-9b02-7f92a38bf902","owner":[],"postedDate":"October 7th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":14772,"name":"Neurology"}],"tags":[],"updatedAt":"","versionOfRecord":{"articleIdentity":"rs-1713","link":"https://doi.org/10.1186/s12883-019-1551-8","journal":{"identity":"bmc-neurology","isVorOnly":false,"title":"BMC Neurology"},"publishedOn":"2019-12-06 12:00:00","publishedOnDateReadable":"December 6th, 2019"},"versionCreatedAt":"2019-10-07 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