RHD*DNT (RHD*38) Showing D-Positive Reactivity on Rhesus D Typing and Forming Anti-D Antibody

Lee GH, Kim H, Mina Hur, Kyeong A So, Shin DW, Hong YJ, Park KU
Annals of laboratory medicine · 2023 · vol. 43(5) , pp. 524–527 · doi:10.3343/alm.2023.43.5.524 · PMID:37080757 · PMC10151267
Other OA: gold
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This report describes the first Korean case of an RHD*DNT variant exhibiting D-positive reactivity and forming anti-D antibodies, contributing to global understanding of this rare blood group phenotype.

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This letter reports the first Korean case of an individual with the RHD*DNT variant who tested D-positive on standard typing but formed anti-D antibodies. Serological analysis using column agglutination and tube methods confirmed strong reactivity with multiple anti-D reagents, while molecular testing identified the specific c.455A>C mutation associated with this partial D phenotype. The authors note that this variant is rare and highlight the clinical importance of recognizing such discrepancies to prevent hemolytic transfusion reactions or hemolytic disease of the fetus and newborn. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Acknowledgements

None. AUTHOR CONTRIBUTIONS Lee GH and Shin DW analyzed the data and wrote the draft; Hur M and Park KU conceived and designed the study, analyzed the data, and finalized the draft; Kim H, So KA, and Hong YJ collected the samples, analyzed the data, and participated in manuscript drafting. All authors have read and approved the final manuscript. CONFLICTS OF INTEREST None declared. RESEARCH FUNDING None declared.

References

- Sandler SG, Chen LN, Flegel WA. Serological weak D phenotypes: a review and guidance for interpreting the RhD blood type using the RHD genotype. Br J Haematol 2017;179:10-9. - Zhang J, Zeng Y, Wang Y, Fan J, Chen H, Yang D, et al. RHD genotypes in a Chinese cohort of pregnant women. Front Genet 2021;12:752485. - Floch A. Molecular genetics of the Rh blood group system: alleles and antibodies-a narrative review. Ann Blood 2021;6:29. - Floch A. Maternal red blood cell alloimmunisation Working Party, literature review. RH blood group system: rare specificities. Transfus Clin Biol 2021;28:314-20. - International Society of Blood Transfusion (ISBT). (ISBT 004) RHD blood group alleles v6.2 30-SEP-2022. https://www.isbtweb.org/resource/004rhd.html (Updated on Nov, 2022). - Hong YJ, Kim H, Song EY, Cho D, Park KU, Han KS. Development of real-time PCR and melting curve analysis for the rapid detection of DEL with RHD (c.1222T>C) orRHD (c.1227G>A). Clin Lab 2016;62:1995-2000. - Jeong D, Oh S, Song EY, Hong YJ, Park KU. Molecular characteristics of the serological weak D phenotype in Koreans. Diagnostics (Basel) 2021;11:920. - von Zabern I, Wagner FF, Moulds JM, Moulds JJ, Flegel WA. D category IV: a group of clinically relevant and phylogenetically diverse partial D. Transfusion 2013;53:2960-73. - Scott M. Section 1A: Rh serology. Coordinator's report. Transfus Clin Biol 2002;9:23-9. - Lomas C, Tippett P, Thompson KM, Melamed MD, Hughes-Jones NC. Demonstration of seven epitopes on the Rh antigen D using human monoclonal anti-D antibodies and red cells from D categories. Vox Sang 1989;57:261-4.

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MeSH descriptors

Rh-Hr Blood-Group System Rh-Hr Blood-Group System Rho(D) Immune Globulin Humans

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