[Demonstration and biological significance of viral and cellular oncogenes in uterine carcinomas]
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public-domain-us
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This study analyzed uterine carcinomas and found HPV DNA in endometrial adenocarcinomas and one case of adenomyosis, while c-myc overexpression was absent in endometrial lesions but present in cervical cancers.
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Abstract
Premalignant and malignant lesions of the cervix uteri and endometrium were analyzed for the presence of human papillomavirus (HPV) DNA and c-myc or c-erbB2/neu oncogene expression. HPV DNA was detected by PCR in 100% of the cervical carcinomas and CIN lesions, but also in endometrial lesions (3/8 adenocarcinomas, two hyperplasias and one adenomyosis uteri). Myc-overexpression was found in 25-30% of the cervical carcinomas and severe dysplasias, but not in endometrial lesions. C-erbB2 was overexpressed in 4/11 endometrial carcinomas and 3/19 CIN3 lesions. The implications of these results are discussed.
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- europepmc
- last seen: 2026-09-06T09:34:12.023084+00:00
- pubmed
- last seen: 2026-05-13T22:12:05.481982+00:00
License: public-domain-us
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine