The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia.

Ghanem MA, Safan MA, Ghanem AA, Dohle GR
Asian journal of andrology · 2011 · doi:10.1038/aja.2011.48 · PMID:21785440 · PMC3739562
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This study is unrelated to endometriosis or adenomyosis, as it investigates antegrade scrotal sclerotherapy for treating varicoceles in men with severe oligo-astheno-teratozoospermia.

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This study evaluated the efficacy of antegrade scrotal sclerotherapy for treating varicoceles in 59 men suffering from severe oligo-astheno-teratozoospermia. Researchers assessed semen parameters and reproductive hormones before and six months after the procedure, noting significant improvements in sperm concentration, motility, morphology, inhibin B levels, and reduced follicle-stimulating hormone levels in a majority of patients. The treatment led to spontaneous pregnancies in nine couples, suggesting it can be an effective alternative to intracytoplasmic sperm injection for this population. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia (OAT). The 59 patients with severe OAT in this study underwent antegrade scrotal sclerotherapy for the treatment of varicoceles. The outcome was assessed in terms of improvement in semen parameters and spontaneous conception rate. Semen parameters and reproductive hormones were evaluated before antegrade sclerotherapy (AS) and 6 months after AS. After an average follow-up time of 34.8±3.2 months, significant improvement was noted in the mean sperm concentration, motility and morphology in 36 patients (61%). Spontaneous pregnancy occurred in nine couples (15%). Six months after treatment, inhibin B levels were significantly higher (P<0.04), whereas follicle-stimulating hormone (FSH) levels were significantly lower (P<0.001) than before treatment. Antegrade internal spermatic vein sclerotherapy can significantly improve seminal parameters and hormonal parameters in men with severe OAT and may even result in spontaneous pregnancy in couples who would otherwise be candidates for intracytoplasmic sperm injection (ICSI).
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| Volume 13, Issue 6 (November 2011) 13, 867–871; 10.1038/aja.2011.48 The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia Mazen A Ghanem1,2, Manal A Safan3, Ashraf A Ghanem4 and Gert R Dohle2 1 Department of Urology, Menoufiya University, 3481 Shebin El-Kom, Egypt 2 Department of Urology, Erasmus MC, 3000 CA Rotterdam, The Netherlands 3 Department of Clinical Biochemistry, Menoufiya University, 3481 Shebin El-Kom, Egypt 4 Department of Gynaecology and Obstetrics, Mansoura University, 35515 Mansoura, Egypt Correspondence: Professor MA Ghanem, ([email protected]) Received 17 December 2010; Revised 20 March 2011; Accepted 4 April 2011; Published online 25 July 2011 | Abstract | | The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia (OAT). The 59 patients with severe OAT in this study underwent antegrade scrotal sclerotherapy for the treatment of varicoceles. The outcome was assessed in terms of improvement in semen parameters and spontaneous conception rate. Semen parameters and reproductive hormones were evaluated before antegrade sclerotherapy (AS) and 6 months after AS. After an average follow-up time of 34.8±3.2 months, significant improvement was noted in the mean sperm concentration, motility and morphology in 36 patients (61%). Spontaneous pregnancy occurred in nine couples (15%). Six months after treatment, inhibin B levels were significantly higher (P<0.04), whereas follicle-stimulating hormone (FSH) levels were significantly lower (P<0.001) than before treatment. Antegrade internal spermatic vein sclerotherapy can significantly improve seminal parameters and hormonal parameters in men with severe OAT and may even result in spontaneous pregnancy in couples who would otherwise be candidates for intracytoplasmic sperm injection (ICSI). Keywords: infertility; Inhibin B; oligo-astheno-teratozoospermia; sclerotherapy; semen parameters; varicocele PDF | PDF | 中文摘要 | | | | | Browse: 4276 | |

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