Effects of danazol on coagulant activity in the rat

C D Lox, Lox CD, Heine MW, M W Heine, F DeLeon, Frank D. DeLeon, S Prein
International journal of fertility · 1992 · vol. 37(1) , pp. 48–52 · PMID:1348736 · W2416648537
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Danazol treatment in female rats caused slight decreases in coagulation factor activities and prolonged prothrombin time, indicating minimal effects on coagulation activity.

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Abstract

Coagulation factor activity was evaluated in female rats treated with danazol. Following 30 days of treatment, slight decreases in factor VII and X activities were noted. After 60 days, a prolongation of the prothrombin time, as well as a decrease in factor VII, was noted. The data suggest that in the rodent, danazol has minimal effects on coagulation activity.

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MeSH descriptors

Blood Coagulation Danazol Animals Blood Coagulation Blood Coagulation Factors Blood Coagulation Factors Danazol Female Fibrinogen Fibrinogen Hemostasis Hemostasis Liver Liver Partial Thromboplastin Time Prothrombin Time Rats Rats, Inbred Strains Time Factors

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SciLite annotations

chemicals 3
danazol danazol danazol
organisms 3
zitter rats rattus sp. rodents

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