SodaSulphanecobalamin as a Broad-Spectrum Medical Countermeasure Agent for Chemical and Biological Threats: Synthesis, Safety, and Comparative Analysis

SodaSulphanecobalamin as a Broad-Spectrum Medical Countermeasure Agent for Chemical and Biological Threats: Synthesis, Safety, and Comparative Analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article SodaSulphanecobalamin as a Broad-Spectrum Medical Countermeasure Agent for Chemical and Biological Threats: Synthesis, Safety, and Comparative Analysis Olatunji N. Salako¹, Idayat Shalewa Salako, Modupe Adebanji Akingbade, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7779935/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Chemical and biological warfare agents (CBWAs) pose significant threats due to their acute toxicity and delayed treatment efficacy. This study evaluates SodaSulphanecobalamin (Na₄S₅CoC₆₉N₁₅H₈₉O₂₆), a novel medical countermeasure (MCM) agent, against diverse CBWAs, including cyanide, sulfur mustard, organophosphates, and dioxins. The antidote’s synthesis involves the thermal decomposition of sodium nitrite (NaNO₂) and sodium thiosulfate (Na₂S₂O₃) at 330–340°C, followed by reaction with hydroxocobalamin under platinum catalysis. The interaction of Nitric Oxide and hydroxocobalamin makes the active ingredient in this Medical Countermeasures Agent. Comparative rat models of acute cyanide toxicity demonstrated SodaSulphanecobalamin superior hemodynamic recovery (baseline mean arterial pressure restored within 5 minutes vs. 28–31 minutes for sodium nitrite-thiosulfate). The agent detoxifies cyanide via chelation, sulfur mustard via sulfur displacement, and organophosphates via phosphonic acid conversion. Unlike mercury-based antidotes for dioxins, SodaSulphanecobalamin eliminates chlorine atoms from 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), forming non-toxic sodium benzoate. With no adverse effects observed in animal trials, this MCM offers a safer, universal antidote platform. Medical countermeasures SodaSulphanecobalamin Cyanide detoxification Organophosphate neutralization Chemical warfare agents Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryMaterialsofthebroadspectrumofMCMAgent.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7779935","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":525062473,"identity":"cfd93107-7641-4de9-9cad-1a804344d011","order_by":0,"name":"Olatunji N. 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