Bibliometric Analysis of Studies Employing Nanotechnology for MRSA Treatment, 2007-2025

preprint OA: closed
Full text JSON View at publisher
AI-generated deep summary by claude@2026-06, 2026-06-24 · read from full text

This preprint reports a bibliometric analysis of publications from 2007 to 2025 on nanotechnology-enabled strategies for treating methicillin-resistant Staphylococcus aureus (MRSA), using Scopus data and visualization of research networks and trends with VOSviewer. It finds that China contributes the most publications, with Asian countries accounting for 70% of the top ten contributing nations, and that the publication volume increased dramatically—by nearly 9,000% from 2007 to 2024. Emerging research themes highlighted include nanozymes, chemodynamic therapy, and photothermal platforms. A major caveat is that the analysis is based on Scopus-indexed studies and the work is explicitly a preprint that has not been peer reviewed. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 18,760 characters · extracted from preprint-html · click to expand
Bibliometric Analysis of Nanotechnology Research for MRSA Treatment (2007–2025) | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Bibliometric Analysis of Nanotechnology Research for MRSA Treatment (2007–2025) Mohammad Javad Golmohammadi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7732327/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Antibiotic resistance in bacteria remains one of the most urgent global health challenges, as emphasized by the World Health Organization. In response, beyond the discovery of new antibiotics, researchers have increasingly turned to nanotechnology to design advanced antibacterial agents capable of targeting resistant strains or enhancing the efficacy of existing therapies, for example by employing nanocarrier-based delivery systems. Methicillin-resistant Staphylococcus aureus (MRSA) represents a particularly critical pathogen due to the difficulties associated with its treatment. In this study, we conducted a bibliometric analysis of research published between 2007 and 2025 on nanotechnology-enabled strategies for MRSA treatment. Data were collected from the Scopus database and visualized using VOSviewer software to map research networks and trends. Our findings reveal that China leads global output in this domain, with Chinese institutions consistently at the forefront. Notably, 70% of the top ten contributing countries are located in Asia, underscoring the region’s dominant role in advancing this field. The publication trend demonstrates an extraordinary increase of nearly 9,000% from 2007 to 2024, reflecting the accelerating momentum of research activity. Emerging topics such as nanozymes , chemodynamic therapy , and photothermal platforms have attracted significant attention, highlighting their potential to overcome current therapeutic limitations. Taken together, these results indicate that nanoscience is rapidly reshaping the landscape of antimicrobial research, and its continued advancement promises to deliver innovative solutions for combating MRSA and other antibiotic-resistant pathogens. Nanoscience Biotechnology and Bioengineering Nanotechnology Nanobiotechnology Pharmaceutical nanotechnology Antimicrobial resistance MRSA Methicillin-resistant Staphylococcus aureus Nanozymes Full Text Additional Declarations The authors declare potential competing interests as follows: The author declares no competing interests, with the exception that their nationality (Iranian) might be regarded as relevant in the context of this publication. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7732327","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":522688769,"identity":"1a2c489a-c0ef-4d87-8f19-ed4eb8219275","order_by":0,"name":"Mohammad Javad Golmohammadi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABBElEQVRIie3PMUsDMRTA8RcCdfHoWjj6HQKBAxHqB3Gx3HoPdDuw1kzXpeJaQepX0CVzjsBlCepY6dLJWZwOupjrULvk2lEw/yF5gfwIAQiF/mBMHW92IkAdrevcjZSKVnKyQyAG2xDSTs5+CUBMiu3sLzF35fdHNugLYt751fzmvDtxpM6ln9jXNEaZcgH2Mn2QBmeaCDK1Sz9ZZMwROnTkQkWyQuEIJYWfsEXG1yhvGzIU0WOFTweQxL2iHTGaRmKEz3uJtckpSsMLsB0yqxS+OFK2/YWZKV+ivO7f98wnfI3GOH/T5arO/WRbp2eZ2/TmoPbfb+pOVm4dH3Y5FAqF/lU/GvFnF8f5Gi8AAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-9277-0023","institution":"Baqiyatallah University of Medical Sciences","correspondingAuthor":true,"prefix":"","firstName":"Mohammad","middleName":"Javad","lastName":"Golmohammadi","suffix":""}],"badges":[],"createdAt":"2025-09-28 07:03:01","currentVersionCode":2,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":true,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-7732327/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-7732327/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":98428743,"identity":"0288bebf-fc48-48a2-8577-ead36c115d6d","added_by":"auto","created_at":"2025-12-17 16:42:19","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":1165602,"visible":true,"origin":"","legend":"","description":"","filename":"BibliometricManuscriptFinal.docx","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/29be955a3cb573c273f845a4.docx"},{"id":98101084,"identity":"c3d8dfac-0385-4ad7-9b6c-bf31af315be7","added_by":"auto","created_at":"2025-12-12 20:31:20","extension":"json","order_by":1,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":342,"visible":true,"origin":"","legend":"","description":"","filename":"rs7732327.json","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/23e66263abf192ff92ca6979.json"},{"id":98101089,"identity":"dbeb48e6-b472-48ad-a381-e371b84c8832","added_by":"auto","created_at":"2025-12-12 20:31:20","extension":"xml","order_by":2,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":156078,"visible":true,"origin":"","legend":"","description":"","filename":"rs77323271enriched.xml","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/232ac8e7190ed88ad865ea1e.xml"},{"id":98430740,"identity":"993ce65d-47f5-4b26-8ae8-317a294dbe7f","added_by":"auto","created_at":"2025-12-17 16:46:07","extension":"jpeg","order_by":3,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":111581,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/8d3c59de88a5818b1298d21c.jpeg"},{"id":98101079,"identity":"8deb7f55-b4c6-43a6-af24-e69488d761ca","added_by":"auto","created_at":"2025-12-12 20:31:20","extension":"jpeg","order_by":4,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":161375,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage2.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/65f7d6e97b5da6b7e466f80f.jpeg"},{"id":98101083,"identity":"6d3bdb58-05a1-4f2e-ab4c-cf8f342ba4c2","added_by":"auto","created_at":"2025-12-12 20:31:20","extension":"jpeg","order_by":5,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":138356,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage3.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/e667d8f17ffae618507fb3c6.jpeg"},{"id":98431016,"identity":"504a2e69-a342-421e-b31b-af9629041e5d","added_by":"auto","created_at":"2025-12-17 16:46:45","extension":"jpeg","order_by":6,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":125526,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage4.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/73236eceb43495c5f5eed720.jpeg"},{"id":98101087,"identity":"319996cb-7040-4ed0-89e4-232f3dd6b555","added_by":"auto","created_at":"2025-12-12 20:31:20","extension":"jpeg","order_by":7,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":532960,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage5.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/9185493133fb5d5c2be07fd3.jpeg"},{"id":98430648,"identity":"8889d34c-0dfb-4a72-bb3e-c85b2648d40e","added_by":"auto","created_at":"2025-12-17 16:45:59","extension":"png","order_by":8,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":32757,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/626f9243f0fc909b413aa631.png"},{"id":98428572,"identity":"d35a225c-1e9f-4b8d-a386-15802a84b9f9","added_by":"auto","created_at":"2025-12-17 16:42:08","extension":"png","order_by":9,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":67746,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/669b8b41072cf96daea22bf3.png"},{"id":98430430,"identity":"1371b26b-e316-4d32-a5c2-db32c10415a3","added_by":"auto","created_at":"2025-12-17 16:45:24","extension":"png","order_by":10,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":105046,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/6d7f0278456781892345c94d.png"},{"id":98430559,"identity":"2b0be0f0-54ed-4fc4-994f-f11747f34a2a","added_by":"auto","created_at":"2025-12-17 16:45:44","extension":"png","order_by":11,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":22839,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage4.png","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/8eae2a89e54be110730212ae.png"},{"id":98430684,"identity":"3ab519de-81ea-4208-9316-196326e3a810","added_by":"auto","created_at":"2025-12-17 16:46:02","extension":"png","order_by":12,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":68428,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage5.png","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/d995346c1f25114f3e87b408.png"},{"id":98430036,"identity":"a7e4c1c3-a977-4142-b4bf-8e3415ae5903","added_by":"auto","created_at":"2025-12-17 16:44:39","extension":"xml","order_by":13,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":154632,"visible":true,"origin":"","legend":"","description":"","filename":"rs77323271structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/67b70a3c894d229252fc15ff.xml"},{"id":98101092,"identity":"89789edb-c7c8-4ffd-bf90-3b11128039b0","added_by":"auto","created_at":"2025-12-12 20:31:20","extension":"html","order_by":14,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":163518,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2/fce2cff32cb1cda6c6937c93.html"},{"id":98622927,"identity":"dc135e8d-073a-4aa2-86e4-1056db32460c","added_by":"auto","created_at":"2025-12-19 17:03:37","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":713036,"visible":true,"origin":"","legend":"","description":"","filename":"BibliometricManuscriptFinal.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7732327/v2_covered_f65371c0-d817-4bd0-b58b-0f0c67a8a4c8.pdf"}],"financialInterests":"The authors declare potential competing interests as follows: The author declares no competing interests, with the exception that their nationality (Iranian) might be regarded as relevant in the context of this publication.","formattedTitle":"\u003cp\u003e\u003cstrong\u003eBibliometric Analysis of Nanotechnology Research for MRSA Treatment (2007–2025)\u003c/strong\u003e\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[{"identity":"341077a7-d368-4302-bcc9-26109fab4fc8","identifier":"10.13039/501100005849","name":"Baqiyatallah University of Medical Sciences","awardNumber":"402000174","order_by":0}],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Baqiyatallah University of Medical Sciences","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Nanotechnology, Nanobiotechnology, Pharmaceutical nanotechnology, Antimicrobial resistance, MRSA, Methicillin-resistant Staphylococcus aureus, Nanozymes","lastPublishedDoi":"10.21203/rs.3.rs-7732327/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7732327/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAntibiotic resistance in bacteria remains one of the most urgent global health challenges, as emphasized by the World Health Organization. In response, beyond the discovery of new antibiotics, researchers have increasingly turned to nanotechnology to design advanced antibacterial agents capable of targeting resistant strains or enhancing the efficacy of existing therapies, for example by employing nanocarrier-based delivery systems. Methicillin-resistant \u003cem\u003eStaphylococcus aureus\u003c/em\u003e (MRSA) represents a particularly critical pathogen due to the difficulties associated with its treatment. In this study, we conducted a bibliometric analysis of research published between 2007 and 2025 on nanotechnology-enabled strategies for MRSA treatment. Data were collected from the Scopus database and visualized using VOSviewer software to map research networks and trends. Our findings reveal that China leads global output in this domain, with Chinese institutions consistently at the forefront. Notably, 70% of the top ten contributing countries are located in Asia, underscoring the region\u0026rsquo;s dominant role in advancing this field. The publication trend demonstrates an extraordinary increase of nearly 9,000% from 2007 to 2024, reflecting the accelerating momentum of research activity. Emerging topics such as \u003cem\u003enanozymes\u003c/em\u003e, \u003cem\u003echemodynamic therapy\u003c/em\u003e, and \u003cem\u003ephotothermal platforms\u003c/em\u003e have attracted significant attention, highlighting their potential to overcome current therapeutic limitations. Taken together, these results indicate that nanoscience is rapidly reshaping the landscape of antimicrobial research, and its continued advancement promises to deliver innovative solutions for combating MRSA and other antibiotic-resistant pathogens.\u003c/p\u003e","manuscriptTitle":"Bibliometric Analysis of Nanotechnology Research for MRSA Treatment (2007–2025)","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2025-12-12 20:31:15","doi":"10.21203/rs.3.rs-7732327/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2025-09-30 07:28:19","doi":"10.21203/rs.3.rs-7732327/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"429db3fa-80ff-4565-af73-bab2a3ac2a53","owner":[],"postedDate":"December 12th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":59134151,"name":"Nanoscience"},{"id":59134152,"name":"Biotechnology and Bioengineering"}],"tags":[],"updatedAt":"2025-09-30T07:28:19+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-12 20:31:15","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-7732327","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7732327","identity":"rs-7732327","version":["v2"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-05-20T01:45:00.602351+00:00