No Smoke Left Behind- Knowledge, Attitudes and Usage of Smokeless Tobacco from the Lens of the Public: A Nationwide Cross-Sectional Study from Pakistan

No Smoke Left Behind- Knowledge, Attitudes and Usage of Smokeless Tobacco from the Lens of the Public: A Nationwide Cross-Sectional Study from Pakistan | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article No Smoke Left Behind- Knowledge, Attitudes and Usage of Smokeless Tobacco from the Lens of the Public: A Nationwide Cross-Sectional Study from Pakistan Hammad Atif Irshad, Sajjan Raja, Hamzah Jehanzeb, Wamiq Ali Shaikh, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4724727/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Smokeless tobacco (SLT) encompasses products that are not burnt but instead consumed orally or nasally. One-third of tobacco is consumed in the smokeless form in South Asia. Despite its widespread usage, there has been limited empirical research on the prevalence of and factors influencing SLT consumption in Pakistan. This study aimed to provide an assessment of SLT knowledge, attitudes, and usage in Pakistan. Methods Using an online questionnaire, a cross-sectional survey was conducted across Pakistan. Convenience sampling was used to disseminate, and expert approval was sought followed by a pilot study to validate the questionnaire. A comprehensive questionnaire was developed using elements from the Global Adult Tobacco Survey and other tools which had previously been utilized within Pakistan. Participants' responses were described using descriptive statistics, and SPSS version 26 was used to perform linear and logistic regression. A p-value of less than 0.05 was considered statistically significant. Results Data was collected from 1,195 participants among which 85.86% of participants had heard of SLTs prior to the survey. Sex, province, household income and previous doctor visits were significant determinants to product knowledge through which 72.55% agreed that these products can lead to serious illnesses but 30% noted a lack of knowledge on legality. General attitudes agreed to a belief that it makes one unwell (44.1%), sense of guilt (43.85%) and more research is needed on it (54.39%). Negative health effects were the biggest deterrent from pursuing these products for 60.33% of participants. Among significant factors influencing the use of SLTs, the greatest odds of use were found with use as an alternative to cigarettes (OR 4.45) and secondly, due to its availability in a liked flavor (OR 2.27). About 31% reported to have used the product once, with 69.82% of current users expressing a desire to quit. Conclusions Although adequate knowledge and aligning attitudes exist for SLTs, light is shed in the face of a sustaining public health problem. We offer important insights that can guide the creation of focused interventions meant to lower SLT use, and the health hazards associated with it in the Pakistani community by highlighting important myths, incentives, and deterrents. chewed tobacco public health snus non-cigarette Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Contributions to the Literature Knowledge regarding SLTs remains high in Pakistan, although many perceived their use as a legal gray area and agreed that more research is needed to gauge their health effects. There exists significant social stigma around their use, with many respondents associating a sense of guilt and unwellness with their use. Significant factors for usage include usage as a cigarette alternative and the variety of available flavors, both of which are selling points leveraged in marketing these products. Most current users report an intent to quit. Background From a vast range of methods used across the globe, tobacco use can be summarized into the two major categories of smoked and smokeless tobacco products (SLT) ( 1 ). SLTs encompass those products that are not burnt but instead consumed orally or nasally ( 2 ). These include Moist snuff (held between the cheek and gum; available in various forms such as Khaini, Snus, Shammaah, Nass, or Naswar), dry snuff (powdered tobacco traditionally inhaled through the nose or taken orally) and chewing tobacco (placed in the mouth and either sucked or chewed ( 1 ). Varieties of smokeless tobacco include Plug, Loose-leaf, Chimo, Toombak, Gutkha, Twist and Pan-masala or Betel-quid, which comprises tobacco, areca nuts, slaked lime, sweeteners, and flavorings wrapped in a betel leaf) ( 1 ). Despite not being combusted, SLTs contain harmful substances including at least 28 cancer causing chemicals (carcinogens) that can lead to numerous health issues( 3 , 4 ). These products pose significant risks to oral health, including gum disease, tooth decay, and oral cancer, stemming from prolonged exposure to carcinogens and irritants( 3 ). Furthermore, smokeless tobacco increases the risk of various cancers beyond the oral cavity, such as esophageal and pancreatic cancer, while also fostering nicotine addiction, complicating cessation efforts. Cardiovascular consequences, including elevated heart rate and blood pressure, contribute to the potential for cardiovascular disease, while reproductive health may also suffer, with implications for fertility and pregnancy outcomes( 3 , 5 ). The prevalence of SLTs is influenced by a variety of demographic factors, including socioeconomic status, ethnic background, gender, and age ( 3 , 5 ). These products are most used in South Asian countries, where one-third of tobacco is consumed in the smokeless form. Increased use of smokeless tobacco products is highly neglected as international governments are more focused on eliminating cigarettes and not tobacco entirely, which is contrary to the article 1 (d) & 1(f) of WHO's Framework Convention on Tobacco Control( 6 ). Furthermore, there is no regulation throughout the manufacturing and sales of SLTs in low- and middle-income countries like Pakistan. This leads to and supports purchase of SLTs, while misconceptions of it being less hazardous or even having medical benefits prevail( 7 , 8 ). From a public health point of view, the use of SLTs poses a massive challenge globally. Contrary to popular belief that smokeless tobacco provides an avenue for current cigarette smokers to quit, it was found that the initial use of SLTs instead paved the way for many adolescents to move on to cigarette smoking( 9 ). The use of SLTs is generally considered socially acceptable and there is a lack of knowledge regarding its detrimental effects on health. In fact, it has been observed that the misconception about the favorable effect of chewing SLTs is common, primarily among the younger age groups( 10 , 11 ). In Pakistan, SLT is predominantly consumed in various forms such as Naswar (tobacco mixed with cardamom and menthol) and Paan or Betel-quid( 2 ). Despite its widespread usage, there has been limited empirical research on the prevalence and factors influencing smokeless tobacco consumption in Pakistan( 2 ). Studies examining the correlation between the use of smokeless tobacco and other substances like areca nut, and their association with head, neck, and oral cancers, have been conducted in specific regions of Pakistan, often with small sample sizes ( 12 – 18 ). This study aimed to provide a comprehensive examination of smokeless tobacco consumption in Pakistan, offering insights into its knowledge, attitudes, motivations, deterrents, and usage patterns among the general public. Methods The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement's reporting guidelines are adhered to in this cross-sectional study( 19 ). Study Design, Setting and Population This cross-sectional study was approved by the Aga Khan University Hospital's (AKUH) Ethical Review Committee (ERC) and was carried out throughout Pakistan using an online questionnaire. This questionnaire was intended for the public which are defined as adults living in Pakistan who are at least eighteen years old in the inclusion criteria. Data Collection Tool In the absence of a prior questionnaire suitable for our population, a comprehensive questionnaire was developed using elements from the Global Adult Tobacco Survey (GATs) and other tools which have previously been utilized within Pakistan ( 20 – 23 ). The English questionnaire was also translated to Urdu, which is the national language of Pakistan, by an independent translator fluent in both languages and with experience in questionnaire translation. To ensure face validity, the English and Urdu versions of the questionnaire underwent pilot testing among 50 respondents. A 7-item knowledge, 27- item attitude and 5 item usage questionnaire were used for pilot testing. Cronbach’s alpha value was calculated for each of these domains to check for internal consistency, with the calculated values being 0.8597, 0.9503 and 0.86 for the knowledge, attitudes, and usage domains respectively. These scores reflected good, excellent, and good consistency respectively. The final components of the questionnaire were then rigorously reviewed in close association with faculty experts in tobacco research at the Section of Pulmonary and Critical Care Medicine at AKUH. Content validity was assessed by calculating a content validity index (CVI) for this survey for relevance, essentiality and clarity based on the ratings of two subject experts. A CVI of 0.942, 0.942 and 0.8986 was calculated for these three parameters respectively, which was deemed acceptable according to Davis (1992) ( 24 ). The final survey contained four sections which were demographics, knowledge, attitudes, and usage. The survey began with a consent form explaining the nature and scope of the survey and then the sections were asked from the respondents. Sample Size Calculation and Sampling Technique The sample size was calculated using OpenEpi( 25 ). According to the Pakistan Demographic and Health Survey 2017-18, the current smoking prevalence among men ages 15–49 is 31.8%( 26 ). Using that statistic, at least 334 participants aged 18 years and above were determined to be recruited. An additional 10% margin of error was taken for a minimum required sample size of 367. For this study, convenience sampling was used to reach adults across the country. The online questionnaire was shared on social media platforms and circulated from person to person. Sampling Technique and Data Collection Procedure Responses were collected by means of a questionnaire that was available in both English and Urdu, the national language of Pakistan. Our questionnaire was circulated among adults (age ≥ 18) as a Google Form, on closed social media platforms, such as WhatsApp groups and Facebook groups. As the data was collected, it was compiled into a Google Sheet. This Google Sheet was password protected and accessible only to members of the research team. Upon completion of data collection, the Google Sheet was downloaded as an Excel sheet, which was password protected. The Google Sheet and individual questionnaire responses were available to the research team for 3 months after data collection was complete, after which they were erased. Statistical Analysis Statistical analyses were run using Statistical Package for Social Sciences (SPSS) version 26. Continuous data such as age were reported using mean and standard deviation. Categorical data consisting of the results of the Likert scales and multiple-choice questions has been reported as frequencies (gross numbers) and percentages (n; %). To analyze the effect of factors such as age, sex, and level of education on the overall knowledge score, a linear regression was performed. In addition, a logistic regression analysis was undertaken to determine significant motivating and deterring factors. A p-value of < 0.05 was considered significant for all analyses. Results Demographics We collected data from a total of 1,195 participants. The median age of the participants stood at 23 years, and there was a fair distribution of gender, with 41.75% identifying as male and 58.24% as female. Geographically, the majority hailed from Sindh (42.09%) and Punjab (32.30%), while other provinces were represented to a lesser degree as displayed in Figure 1 . Ethnically, the largest contingent identified as Urdu speaking (29.29%), followed by Punjabi (22.51%), and Pashtun (17.49%). Educational levels varied, with 62.59% holding bachelor's degrees and 26.11% possessing postgraduate degrees. Most of the respondents were unmarried (79.83%), while monthly income majorly ranged from PKR 100,000 to 500,000 (43.26%) and PKR 50,000 to 100,000 (26.69%). Additionally, the majority reported visiting a healthcare provider 1-2 times in the past 12 months (50.63%). These data have been summarized in Table 1 . Knowledge Towards SLTs Most participants (85.86%) demonstrated prior awareness of smokeless tobacco before the survey. When questioned about the contents of smokeless tobacco, 51.38% believed it contained both tobacco and nicotine, 20.92% believed it contained only nicotine, and 16.49% believed it contained only tobacco. Approximately 5% of participants held the view that neither substance was present. In terms of perceptions of harm, 54.23% believed that smokeless tobacco is equally harmful as traditional cigarettes, while 25.27% considered it less harmful, and 17.82% deemed it more harmful. A minor percentage (2.68%) perceived it to be not harmful at all. Notably, 43.68% believed these products were not prohibited by law, and 30.29% were uncertain about their legal status as displayed in Figure 2 . Concerning health risks, 72.55% concurred that these products can lead to serious illnesses such as cancer and stroke. In addition, a majority disagreed with the notion that occasional use of these products is non-addictive or harmless, with 30.63% expressing strong disagreement. Meanwhile, 22.85% believed these products assist in quitting cigarettes, and 27.53% adopted a neutral stance on the matter. Finally, a substantial proportion, 63.26%, strongly disagreed that these products are safe during pregnancy, and 62.59% strongly disagreed that they are safe for individuals with underlying medical conditions such as heart disease, blood pressure, and diabetes as displayed in Figure 3 . On linear regression analysis ( Table 2 ) to determine significant factors affecting knowledge, females had greater odds to higher knowledge scores, respondents from Punjab had 33% lower odds of higher knowledge compared to respondents from Sindh. Higher monthly household income (1.8 times greater odds of the 100,000-500,000 group) and doctor visits (greater than 1) both were associated with greater odds of higher knowledge scores. Attitudes towards SLTs Concerning attitudes toward smokeless tobacco, a significant majority either disagreed or strongly disagreed that it makes one happy (65.78%) and feel young (69.62%). Conversely, participants agreed or strongly agreed that the use of these products could lead to feeling unwell or sick (44.10%) and evoke a sense of shame or guilt (43.85%). Interestingly, the majority also expressed disagreement or strong disagreement with the notion that these products are exclusive to adults (44.77%) and that the health effects are genetic and don't happen to everyone (67.03%). Additionally, a substantial number of participants (54.39%) believed that further research on these products is required. These data are summarized in Figure 4 . We investigated the influence of various motivators on prompting individuals to consider or adopt smokeless tobacco products as shown in Figure 5 . Notably, the most substantial impact was attributed to the perception that these products aid in stress reduction, with 25.36% of participants acknowledging a significant impact. Furthermore, the pleasurable experience offered by these products had a significant impact on 22.68% of respondents, and the ease of acquisition played a significant impact on 23.60%. Motivations such as favorite flavors (46.95%) and the absence of offensive odors or pleasant smells (45.78%) were influential. Social factors were also relevant, as having friends or family members using these products (20.33%) and the perception of appearing "cool" (17.57%) held a significant impact. Positive media portrayals (19.08%) and the perception of these products as an alternative to cigarettes (20.17%) were additional contributors to motivation. An evaluation of various deterrents discouraging individuals from embracing smokeless tobacco products revealed notable impacts. Foremost among these deterrents was the concern about the negative health effects of the product, as reported by 60.33% of participants. Similarly, the social unacceptability or stigma associated with these products had a significant impact on 45.57% of respondents. 33.14% respondents claimed that cost factor played a significant role in deterring them from using these products. Factors such as negative taste and smell (48.20%), environmental pollution (41.76%), and the potential spread of secondhand smoke to family and friends (46.11%) emerged as demotivators. Additionally, a significant percentage expressed that the fear of addiction (56.07%) and opposition from family members and friends (51.05%) had a significant impact in not pursuing them. These data have been displayed in Figure 6 . Usage of SLTs In terms of usage, a total of 30.54% of respondents acknowledged having used smokeless tobacco products at least once, while the majority (69.46%) had not. Among past users of SLTs, 20.92% used it daily, while the majority used it less than daily (47.96%). In comparison, 31.95% of current users used SLTs daily while 35.50% used it less than daily. Concerning intentions to quit, 69.82% of current users expressed a desire to quit, while 30.18% indicated no plans to quit. These data have been summarized in Table 3 . On logistic regression ( Table 4 ) to determine significant factors influencing the use of SLTs, the greatest odds of use were found with use as an alternative to cigarettes (OR 4.45) and secondly, due to its availability in a liked flavor (OR 2.27). Respondents who felt SLTs made them look cool had lesser odds of using them at least once (OR 0.58). No significant deterrents were found to influence SLT use. Discussion Our study finds that the majority of the participants had heard of SLTs prior to the study and had a fair degree of knowledge regarding the product content and health effects, with negative health impact being a significant deterrent to use. It is to be noted that the laws pertaining to SLTs were debated among respondents and attitudes leaned towards the negative side. Motivating factors included as an alternative to cigarettes, outlook of the drug on perceived popularity and widespread availability in flavors. The utilization of SLTs presents an escalating public health issue, with approximately 360 million individuals worldwide engaging in its consumption, predominantly concentrated in the South Asian region where over 90% of users reside( 27 ). Despite its well-understood association with various disease states, the prevalence of SLTs is steadily increasing within South Asian nations ( 28 – 30 ). More than half the participants answered the composition of SLTs correctly, while at the same time a surprising 21% believed it contained only nicotine and 16.5% thought SLTs had tobacco only. The common forms of smokeless tobacco in Pakistan include Naswar, Chalia, Pan (betel with tobacco), and Gutka( 31 ). All of these compositions contain tobacco with varying degrees of nicotine based on regional preferences. A survey on rural Bangladeshi adolescents revealed that 32.5% of the participants did not know SLTs contain nicotine, and according to the Bangladesh Global Adult Tobacco Survey 2015, 58% of the non-users implicated that SLTs contain nicotine( 32 , 33 ). Although lack of prior study examining the public's knowledge of SLTs ingredients in Pakistan, hindered direct comparison, our findings are comparable to the available data. Concerning health risks, 72.55% of our respondents concurred that these products can lead to serious illnesses such as cancer and stroke. One study from Karachi, Pakistan, revealed that 44% males and 37% females thought it is bad for health. 54% of our survey participants believed that SLTs are equally harmful, and 25% believed they are less harmful compared to traditional cigarettes( 34 ). This statistic is in accordance with a previous study conducted in Poland, which demonstrated that 72% of their respondents perceived SLTs to be as harmful and 25% to be less harmful than cigarettes ( 35 ). Another survey from Bangladesh revealed that only one-quarter of their participants thought SLTs were less harmful than smoked tobacco( 32 ). The perceived severity of SLTs compared to traditional smoked cigarettes is low among our participants, thereby contributing to a higher likelihood of individuals choosing to use smokeless tobacco ( 36 ). Emotional associations with smokeless tobacco were also explored in detail in our study. Participants' rejection of the notion that SLT use evokes a sense of feeling happy or young likely reflects an increasing awareness of the health risks associated with smokeless tobacco consumption ( 37 , 38 ). This shift in perception underscores societal attitudes, indicating a growing understanding of its adverse effects on health and well-being. Respondents associated a sense of guilt and unwellness with smokeless tobacco use likely stems from societal efforts to promote tobacco cessation, and it may contribute to individuals feeling morally conflicted and physically unwell when using smokeless tobacco products. The majority of our respondents disagreed that smokeless tobacco products are exclusively for adults. In recent years, a shift from smoked tobacco products to SLTs is seen among the younger population in Western countries ( 39 ). A survey noted that more than 300 kids ages 12–17 started using smokeless tobacco for the first time in the US( 40 ). The drift towards smokeless tobacco in the South Asian younger population is also in the process. A recent study from India revealed that the majority of students initiating SLTs were in the 10–11 years age group, and 11% of the students enrolled in classes 9–11 were consuming SLTs ( 41 ). The availability and accessibility of smokeless tobacco products, coupled with limited regulatory measures, contribute to their widespread use among younger populations ( 42 ). Exploring the factors in encouraging the use of SLTs in our participants, we found that the perception of SLTs as a stress reliever, pleasurable experience after the use of these products, and ease of acquisition played a crucial role. A grounded theory study conducted in Iran, similarly, revealed that along with the addictive nature of SLTs, relaxation and euphoria were some of the prominent continuation factors( 43 ). Ease of acquisition and unregulated distribution play a pivotal role in the widespread prevalence of these products in the South Asian region( 44 , 45 ). Naswar, a common form of SLT is widely available in 20g packing costing 10 Pakistani rupees (US $ 0.04), which can be consumed several times a day ( 46 , 47 ). Social influences from friends and family members who use smokeless tobacco products can normalize and promote their usage among the population, particularly among young individuals who may be influenced by peer behavior( 48 ). Positive media representations of SLTs and their portrayal as an alternative to cigarettes can shape public perception, influencing individuals to perceive these products as attractive and potentially safer alternatives. Pertinent factors in discouraging the use of SLTs in our respondents included negative health effects. Previous studies have demonstrated that the harmful health impacts of SLTs serve as the main deterrent( 49 ). The stigma attached to SLTs and the fear of addiction act as significant deterrents among our participants. The stigma stems from societal perceptions of these products as unappealing or undesirable, leading to fear of being judged, hence avoiding their use altogether. The fear of addiction underscores apprehensions about the long-term consequences of tobacco use, further discouraging its uptake. A minority of respondents reported having used SLTs before, although higher than previous reports of 19–21% prevalence( 50 ). This is likely attributable to our sample having a greater degree of education and being primarily from the young adult age group. Previous studies have found associations with SLT use and age, with highest prevalence in the 30–39 age group and lowest in those with the highest level of education( 51 ). Future studies should be translated into regional languages of Sindhi, Pashto, Balochi and Seraiki and venture into rural areas of Pakistan and places where our web-based survey was unable to reach. Of particular note in the patterns of use was that daily usage of SLTs had decreased from past to current users, signifying decreased initiative in procuring the product. A reason for this could be the warning given in tobacco packaging( 52 ). This impact can further be enhanced by ensuring the inclusion of all STP kinds in the law and further increasing the degree of warning provided on packaging, a challenge the government continues to face( 53 ). This serves to show that interventions, if conducted in a proper manner have the potential to give results. Strengths This study is first of its kind in this region to inquire on knowledge, attitudes and usage of SLTs in Pakistan and has the potential to pave the way for future research along with facilitating the development of policy. This study includes a new web based comprehensive questionnaire which was developed using elements from the Global Adult Tobacco Survey (GATs) and considerate reviewing was done to increase reliability of the questionnaire. An adequate sample size of 1195 participants were used, which increased the power of the statistical test. Limitations The uneven representation throughout provinces is a crucial finding that highlights the need for more study to fully understand the various regional variations in the use of smokeless tobacco. Moreover, most of the study's sample comprises persons with greater educational attainment, potentially skewing the findings and limiting their generalizability to the broader population. Additionally, as one of the pioneering investigations into SLT use in Pakistan with a substantial sample size, the study lacks comparative data from similar studies, hindering the ability to contextualize its findings. Our study focuses on younger university students who have a greater awareness of health risks and are more impacted by social stigma. This limits our ability to identify accurate deterrents for smokeless tobacco (SLT) use within this group and highlights the need for further research on factors influencing SLT use in a broader population. Study Recommendations SLTs have been in the tobacco market for a long-time making interventions to reduce use a public health priority. Public interventions should aim to reduce accessibility to the product while continuing to promote public awareness campaigns on the health risks of chewing tobacco. By making SLTs less inexpensive, greater taxes can discourage use. In order to restrict advertising and accessibility, it is also crucial to enforce strict marketing laws. In addition, with the emergence of branded forms of SLTs, monitoring of marketing is important to prevent early age exposure. Equally important is packaging, which can reduce attraction and warn consumers of potential hazards by requiring plain packaging with health warnings. Campaigns directed by the government should encourage cessation support, and marketing efforts should be evidence-based and highlight health risks. Conclusions In summary, our research contributes to a better understanding of SLTs in Pakistan. Our findings underscore the urgent need for targeted public health interventions to address misconceptions, deter use, and promote cessation efforts in the face of an escalating public health issue. SLTs have been within public use in the form of chewable tobacco for a long time, however the emergence of newer varieties requires policy intervention to regulate usage. By identifying key misconceptions, motivations, and deterrents, we provide valuable insights that can inform the development of targeted interventions aimed at reducing smokeless tobacco use and its associated health risks in the Pakistani population. Abbreviations Smokeless tobacco (SLT) Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Aga Khan University Hospital's (AKUH) Ethical Review Committee (ERC) Global Adult Tobacco Survey (GATs) Content validity index (CVI) Statistical Package for Social Sciences (SPSS) Interquartile range (IQR) Pakistani Rupees (PKR) Odds Ratio (OR) Aga Khan University (AKU) Declarations Ethics approval and consent to participate Our study obtained ethical clearance from the Ethical Review Committee (ERC) at the Aga Khan University (ID: 2023-8608-24823). The form initially obtained informed consent, detailing the scope of the study, the right of the participant to withdraw from the study at any time and the maintenance of confidentiality of the participants. If the participant agreed to take part in the study, they were able to fill the rest of the questionnaire. To maintain the privacy of the participants, identifiers such as name were not asked. In addition, to maintain anonymity, the questionnaire did not record respondents’ names. There were no risks, immediate benefits, or incentives for participation in the survey. Consent for publication Not applicable. Availability of data and materials Additional data is available on reasonable request from the corresponding author. Please note that all data has been provided in the manuscript. Competing interests The authors declare that they have no competing interests. Funding None. Authors’ contributions HAI, NI and JAK conceptualized the study and devising the methodology. US, WAS, AS and SR were instrumental in the data collection and recruitment of participants by disseminating the questionnaire, while HAI, HJ, and SARM were the major contributors in analyzing and interpreting data. HAI, US, MS and WAS contributed to the initial draft while HAI, HJ and SARM were major contributors in editing the manuscript. HAI, HJ, and SARM critically reviewed the results and suggested changes. All authors approved of the final manuscript. Acknowledgments The authors express their gratitude to the Aga Khan University (AKU) Section of Pulmonary and Critical Care Medicine, specifically to Dr. Talha Shahzad for his assistance in creating the study instrument and Ms. Rubeena Irfan for her administrative support. We would also like to thank Muhammad Ali Akbar Khan (AKU) and Taha Shaikh (AKU) for reviewing the final manuscript. References WHO - types of tobacco use [Internet]. [cited 2024 Apr 15]. Available from: https://www.afro.who.int/sites/default/files/2017-09/Chapter%201.%20Types%20of%20tobacco%20use_1.pdf WHO EMRO | Smokeless tobacco consumption in a multi-ethnic community in Pakistan: a cross-sectional study | Volume 20, issue 6 | EMHJ volume 20, 2014 [Internet]. [cited 2024 Apr 5]. 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Available from: https://tobaccoatlas.org/challenges/smokeless/ Khawaja MR, Mazahir S, Majeed A, Malik F, Merchant KA, Maqsood M, et al. Chewing of betel, areca and tobacco: perceptions and knowledge regarding their role in head and neck cancers in an urban squatter settlement in Pakistan. Asian Pac J Cancer Prev. 2006;7(1):95–100. WHO [Internet]. 2008 [cited 2024 May 21]. WHO report on the global tobacco epidemic, 2008: the MPOWER package. Available from: https://www.who.int/publications/i/item/9789241596282 Chugh A, Arora M, Jain N, Vidyasagaran A, Readshaw A, Sheikh A, et al. The global impact of tobacco control policies on smokeless tobacco use: a systematic review. Lancet Glob Health. 2023 Jun;11(6):e953–68. Bile KM, Shaikh JA, Afridi HUR, Khan Y. Smokeless tobacco use in Pakistan and its association with oropharyngeal cancer. East Mediterr Health J. 2010;16 Suppl:S24-30. Ullah MZ, Lim JN, Ha MA, Rahman MM. Smokeless tobacco use: pattern of use, knowledge and perceptions among rural Bangladeshi adolescents. PeerJ. 2018 Aug 21;6:e5463. Naznin E, George J, Driezen P, Palazzi K, Wynne O, Nargis N, et al. Trend over time on knowledge of the health effects of cigarette smoking and smokeless tobacco use in Bangladesh: Findings from the International Tobacco Control Policy Evaluation Bangladesh Surveys. Drug Alcohol Rev. 2023 Nov;42(7):1838–49. Iqbal N, Sheikh MDA, Riaz SU, Irfan M, Awan S, Khan MW, et al. Differences in gender perception of smokeless tobacco. Int J Tuberc Lung Dis. 2022 Aug 1;26(8):795–7. Jankowski M, Wrześniewska-Wal I, Ostrowska A, Lusawa A, Wierzba W, Pinkas J. Perception of Harmfulness of Various Tobacco Products and E-Cigarettes in Poland: A Nationwide Cross-Sectional Survey. Int J Environ Res Public Health. 2021 Aug 20;18(16). Islam FMA, Walton A. Tobacco Smoking and Use of Smokeless Tobacco and Their Association with Psychological Distress and Other Factors in a Rural District in Bangladesh: A Cross-Sectional Study. J Environ Public Health. 2019 Dec 6;2019:1–11. Kankaria A, Sahoo SS, Verma M. Awareness regarding the adverse effect of tobacco among adults in India: findings from secondary data analysis of Global Adult Tobacco Survey. BMJ Open. 2021 Jun 28;11(6):e044209. Hettiarachchi P, Jayasooriya P, Amarasinghe H, Siriwardena B, Wijerathne D, Kithalawa arachchi S, et al. Knowledge and Attitudes of Nursing Students Towards Smokeless Tobacco and Areca Nut Control in Central Province of Sri Lanka. Asian Pacific Journal of Cancer Care. 2020 Aug 15;5(3):133–8. CDC [Internet]. 2022 [cited 2024 May 21]. Tobacco Product Use and Associated Factors Among Middle and High School Students — National Youth Tobacco Survey, United States, 2021. 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A model to explain smokeless tobacco consumption in adults: A grounded theory study. Heliyon [Internet]. 2023 Oct 1 [cited 2024 Jun 24];9(10). Available from: /pmc/articles/PMC10589854/ Imam SZ, Nawaz H, Sepah YJ, Pabaney AH, Ilyas M, Ghaffar S. Use of smokeless tobacco among groups of Pakistani medical students – a cross sectional study. BMC Public Health. 2007 Dec 3;7(1):231. Ahmad F, Khan Z, Siddiqi K, Khan MN, Kibria Z, Forberger S, et al. Awareness, perceptions of and compliance with tobacco control policies among naswar vendors in Khyber Pakhtunkhwa Pakistan. Tob Control. 2022 Dec;31(e2):e111–7. Ahmad F, Boeckmann M, Khan Z, Zeeb H, Khan MN, Ullah S, et al. Implementing smokeless tobacco control policy in Pakistan: a qualitative study among Naswar supply chain actors. Tob Control. 2021 Sep;30(5):548–52. Khan Z, Dreger S, Shah SMH, Pohlabeln H, Khan S, Ullah Z, et al. Oral cancer via the bargain bin: The risk of oral cancer associated with a smokeless tobacco product (Naswar). PLoS One. 2017 Jul 10;12(7):e0180445. Shahjahan Md, Harun MdGD, Chowdhury ABMA, Ahmed K, Khan HTA. Factors Influencing the Initiation of Smokeless Tobacco Consumption Among Low Socioeconomic Community in Bangladesh: A Qualitative Investigation. Int Q Community Health Educ. 2017 Jul 10;37(3–4):181–7. Ullah MZ, Lim JN, Ha MA, Rahman MM. Smokeless tobacco use: pattern of use, knowledge and perceptions among rural Bangladeshi adolescents. PeerJ. 2018 Aug 21;6:e5463. Niaz K, Maqbool F, Khan F, Bahadar H, Ismail Hassan F, Abdollahi M. Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer. Epidemiol Health. 2017;39:e2017009. Abbas SM, Alam AY, Usman M, Siddiqi K. Smokeless tobacco consumption in a multi-ethnic community in Pakistan: a cross-sectional study. East Mediterr Health J. 2014 Jun 18;20(6):385–90. Abdullah SM, Huque R, Siddiqi K, Kanaan M, Huque S, Ullah S, et al. 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Tables Table 1: Demographics Characteristics IQR: Interquartile range; N=1195 *IQR has been reported as (Q1 – Q3) Variable n (%)/Median (IQR)* Age (Years) 23 (5) Sex Male Female 499 (41.75) 696 (58.24) Province of residence Sindh Punjab Khyber Pakhtunkhwa Balochistan Islamabad Capital Territory Azad Jammu and Kashmir Gilgit Baltistan 503 (42.09) 386 (32.30) 176 (14.73) 52 (4.35) 48 (4.02) 25 (2.09) 5 (0.42) City of residence Karachi Lahore Peshawar Bahawalpur Islamabad Quetta Rawalpindi Hyderabad Multan Gujrat Tando Allahyar Faisalabad Rahim Yar Khan Gujranwala Muzaffarabad Ghotki Abbottabad Charsadda Narowal Dera Ismail Khan Mirpur Khas Other 434 (36.32) 130 (10.88) 128 (10.71) 65 (5.44) 57 (4.77) 51 (4.27) 46 (3.85) 33 (2.76) 23 (1.92) 18 (1.51) 13 (1.09) 11 (0.92) 10 (0.84) 9 (0.75) 9 (0.75) 8 (0.67) 7 (0.59) 7 (0.59) 7 (0.59) 5 (0.42) 5 (0.42) 119 (9.96) Ethnicity Punjabi Urdu-speaking Sindhi Pashtun Baloch Mixed Other 269 (22.51) 350 (29.29) 156 (13.05) 209 (17.49) 19 (1.59) 52 (4.35) 140 (11.72) Level of Education 14 years (Postgraduate degree) 2 (0.17) 9 (0.75) 124 (10.38) 748 (62.59) 312 (26.11) Marital Status Unmarried Married 954 (79.83) 241 (20.17) Monthly Family Income (PKR) 500,000 69 (5.77) 118 (9.87) 319 (26.69) 517 (43.26) 172 (14.39) How many times did you visit a doctor or health care provider in the past 12 months? 0 1 or 2 3 to 5 6 or more 272 (22.76) 605 (50.63) 218 (18.24) 100 (8.37) PKR (Pakistani Rupees); IQR (Interquartile range) Table 2: Linear Regression to Determine Factors affecting Knowledge regarding SLTs Variable Odds Ratio P-Value Age (years) 1.00 0.295 Sex Female Male 1 (reference) 0.73 0.004* Level of Education No formal education 14 years (Postgraduate degree) 1 (reference) 5.52 24.12 25.37 17.82 17.74 0.607 0.174 0.115 0.137 0.146 Marital Status Unmarried Married Divorced Widowed 1 (reference) 0.92 2.91 2.34 0.557 0677 0.533 Province of Residence Sindh AJK Balochistan Gilgit Baltistan Islamabad Capital Territory KPK Punjab 1 (reference) 0.91 0.79 2.64 0.84 1.02 0.67 0.806 0.363 0.233 0.534 0.888 0.001* Monthly Household Income (PKR) 500,000 1 (reference) 0.76 1.09 1.80 1.45 0.736 0.207 0.007* 0.159 Number of Doctor Visits in Past 12 Months 0 1 or 2 3 to 5 6 or more 1 (reference) 0.97 1.24 0.93 0.03* 0.797 0.094 Table 3: Usage of SLTs N=1195 Variable n (%) Have you ever used any type of SLTs, even once? Yes No 365 (30.54) 830 (69.46) Used SLTs at least once or currently using (N= 365) Type of SLT or Similar Product Used (More than one may apply per respondent) Chewing tobacco, such as loose leaf, plug, twist roll VELO/Oral Nicotine Pouches Snuff/Naswar Lozenges Orbs Sticks Strips Other 43 (11.78) 88 (24.11) 20 (5.48) 13 (3.56) 6 (1.64) 7 (1.92) 7 (1.92) 14 (3.84) Past Users of SLTs (N= 196) How often did you use smokeless tobacco products in the past? Daily Less than daily Don't know 41 (20.92) 94 (47.96) 61 (31.12) Active Users of SLTs (N= 169) How much do you currently spend on it per week? (PKR) 3000 Don’t know 45 (26.63) 25 (14.79) 10 (5.91) 19 (11.24) 70 (41.42) How often do you use smokeless tobacco products currently? Daily Less than daily Don't know 54 (31.95) 60 (35.50) 55 (32.54) Do you plan on quitting? Yes No 118 (69.82) 51 (30.18) Abbreviations used: PKR (Pakistani Rupees), SLT (Smokeless Tobacco) Table 4: Logistic Regression to Determine Factors Influencing the Use of SLTs At Least Once *Adjusted for Age, Gender, Province, Ethnicity, Marital Status, Level of Education and Monthly Family Income Variable Odds Ratio P -Value Motivators Easy to acquire 0.68 0.181 Enjoyable experience 1.10 0.746 Gets rid of stress 0.92 0.800 Comes in flavors I like 2.27 0.008* No offensive odor 1.33 0.317 A friend/family member uses 0.93 0.803 It makes one look cool 0.58 0.032* Positively portrayed in media 0.77 0.326 Alternative to cigarettes 4.45 <0.001* Cheaper than others 1.04 0.891 Deterrents Negative health effects 0.93 0.816 Not socially acceptable 0.64 0.103 Expensive 0.88 0.601 Bad taste/smell 0.71 0.182 Environmental pollution 0.94 0.821 Second hand spread to family 0.82 0.485 Do not want to get addicted 1.18 0.576 Negative portrayal in media 0.82 0.478 Difficult to acquire 0.85 0.534 Opposed by family and friends 1.04 0.888 Additional Declarations No competing interests reported. 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12:18:34","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":165040,"visible":true,"origin":"","legend":"\u003cp\u003eGeneral Knowledge regarding SLTs\u003c/p\u003e","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-4724727/v1/97638281d88ac9042da8daa4.png"},{"id":62219964,"identity":"23cd2b42-9c14-4e75-86c2-1605f3aa0134","added_by":"auto","created_at":"2024-08-11 12:18:34","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":71879,"visible":true,"origin":"","legend":"\u003cp\u003eHealth-Associated Knowledge regarding SLTs\u003c/p\u003e","description":"","filename":"Figure3new.png","url":"https://assets-eu.researchsquare.com/files/rs-4724727/v1/37f28d34b829f5b46481a08b.png"},{"id":62221254,"identity":"8e53b504-94fc-46c1-9514-fa371571c096","added_by":"auto","created_at":"2024-08-11 12:26:34","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":92804,"visible":true,"origin":"","legend":"\u003cp\u003eGeneral Attitudes towards SLTs\u003c/p\u003e","description":"","filename":"Figure4.png","url":"https://assets-eu.researchsquare.com/files/rs-4724727/v1/2fd8bff584f10fdb77a07c4a.png"},{"id":62219963,"identity":"3521628e-da25-46cd-bc5a-7e51dbbbf6df","added_by":"auto","created_at":"2024-08-11 12:18:34","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":74950,"visible":true,"origin":"","legend":"\u003cp\u003eFactors encouraging the use of SLTs\u003c/p\u003e","description":"","filename":"Figure5.png","url":"https://assets-eu.researchsquare.com/files/rs-4724727/v1/198e147bf95166f64e9067cc.png"},{"id":62219968,"identity":"3edf70cc-5408-46d2-8949-5aba1ed6d9e1","added_by":"auto","created_at":"2024-08-11 12:18:34","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":80267,"visible":true,"origin":"","legend":"\u003cp\u003eFactors deterring use of SLTs\u003c/p\u003e","description":"","filename":"Figure6.png","url":"https://assets-eu.researchsquare.com/files/rs-4724727/v1/0fa1c00c991f7c26a06007a1.png"},{"id":62607491,"identity":"59ded814-b821-4a95-a70c-38f57086d173","added_by":"auto","created_at":"2024-08-16 11:10:28","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1725082,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4724727/v1/730fa3d1-a7fe-45f6-bbc8-799337eab3b9.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"No Smoke Left Behind- Knowledge, Attitudes and Usage of Smokeless Tobacco from the Lens of the Public: A Nationwide Cross-Sectional Study from Pakistan","fulltext":[{"header":"Contributions to the Literature","content":"\u003cul\u003e\n \u003cli\u003eKnowledge regarding SLTs remains high in Pakistan, although many perceived their use as a legal gray area and agreed that more research is needed to gauge their health effects.\u003c/li\u003e\n \u003cli\u003eThere exists significant social stigma around their use, with many respondents associating a sense of guilt and unwellness with their use.\u003c/li\u003e\n \u003cli\u003eSignificant factors for usage include usage as a cigarette alternative and the variety of available flavors, both of which are selling points leveraged in marketing these products.\u003c/li\u003e\n \u003cli\u003eMost current users report an intent to quit.\u003c/li\u003e\n\u003c/ul\u003e"},{"header":"Background","content":"\u003cp\u003eFrom a vast range of methods used across the globe, tobacco use can be summarized into the two major categories of smoked and smokeless tobacco products (SLT) (\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e). SLTs encompass those products that are not burnt but instead consumed orally or nasally (\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e). These include Moist snuff (held between the cheek and gum; available in various forms such as Khaini, Snus, Shammaah, Nass, or Naswar), dry snuff (powdered tobacco traditionally inhaled through the nose or taken orally) and chewing tobacco (placed in the mouth and either sucked or chewed (\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e). Varieties of smokeless tobacco include Plug, Loose-leaf, Chimo, Toombak, Gutkha, Twist and Pan-masala or Betel-quid, which comprises tobacco, areca nuts, slaked lime, sweeteners, and flavorings wrapped in a betel leaf) (\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eDespite not being combusted, SLTs contain harmful substances including at least 28 cancer causing chemicals (carcinogens) that can lead to numerous health issues(\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e). These products pose significant risks to oral health, including gum disease, tooth decay, and oral cancer, stemming from prolonged exposure to carcinogens and irritants(\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e). Furthermore, smokeless tobacco increases the risk of various cancers beyond the oral cavity, such as esophageal and pancreatic cancer, while also fostering nicotine addiction, complicating cessation efforts. Cardiovascular consequences, including elevated heart rate and blood pressure, contribute to the potential for cardiovascular disease, while reproductive health may also suffer, with implications for fertility and pregnancy outcomes(\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThe prevalence of SLTs is influenced by a variety of demographic factors, including socioeconomic status, ethnic background, gender, and age (\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e). These products are most used in South Asian countries, where one-third of tobacco is consumed in the smokeless form. Increased use of smokeless tobacco products is highly neglected as international governments are more focused on eliminating cigarettes and not tobacco entirely, which is contrary to the article 1 (d) \u0026amp; 1(f) of WHO's Framework Convention on Tobacco Control(\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eFurthermore, there is no regulation throughout the manufacturing and sales of SLTs in low- and middle-income countries like Pakistan. This leads to and supports purchase of SLTs, while misconceptions of it being less hazardous or even having medical benefits prevail(\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eFrom a public health point of view, the use of SLTs poses a massive challenge globally. Contrary to popular belief that smokeless tobacco provides an avenue for current cigarette smokers to quit, it was found that the initial use of SLTs instead paved the way for many adolescents to move on to cigarette smoking(\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e). The use of SLTs is generally considered socially acceptable and there is a lack of knowledge regarding its detrimental effects on health. In fact, it has been observed that the misconception about the favorable effect of chewing SLTs is common, primarily among the younger age groups(\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eIn Pakistan, SLT is predominantly consumed in various forms such as Naswar (tobacco mixed with cardamom and menthol) and Paan or Betel-quid(\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e). Despite its widespread usage, there has been limited empirical research on the prevalence and factors influencing smokeless tobacco consumption in Pakistan(\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e). Studies examining the correlation between the use of smokeless tobacco and other substances like areca nut, and their association with head, neck, and oral cancers, have been conducted in specific regions of Pakistan, often with small sample sizes (\u003cspan additionalcitationids=\"CR13 CR14 CR15 CR16 CR17\" citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThis study aimed to provide a comprehensive examination of smokeless tobacco consumption in Pakistan, offering insights into its knowledge, attitudes, motivations, deterrents, and usage patterns among the general public.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eThe Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement's reporting guidelines are adhered to in this cross-sectional study(\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e).\u003c/p\u003e \u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eStudy Design, Setting and Population\u003c/h2\u003e \u003cp\u003e This cross-sectional study was approved by the Aga Khan University Hospital's (AKUH) Ethical Review Committee (ERC) and was carried out throughout Pakistan using an online questionnaire. This questionnaire was intended for the public which are defined as adults living in Pakistan who are at least eighteen years old in the inclusion criteria.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003eData Collection Tool\u003c/h2\u003e \u003cp\u003eIn the absence of a prior questionnaire suitable for our population, a comprehensive questionnaire was developed using elements from the Global Adult Tobacco Survey (GATs) and other tools which have previously been utilized within Pakistan (\u003cspan additionalcitationids=\"CR21 CR22\" citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThe English questionnaire was also translated to Urdu, which is the national language of Pakistan, by an independent translator fluent in both languages and with experience in questionnaire translation.\u003c/p\u003e \u003cp\u003eTo ensure face validity, the English and Urdu versions of the questionnaire underwent pilot testing among 50 respondents. A 7-item knowledge, 27- item attitude and 5 item usage questionnaire were used for pilot testing. Cronbach\u0026rsquo;s alpha value was calculated for each of these domains to check for internal consistency, with the calculated values being 0.8597, 0.9503 and 0.86 for the knowledge, attitudes, and usage domains respectively. These scores reflected good, excellent, and good consistency respectively.\u003c/p\u003e \u003cp\u003eThe final components of the questionnaire were then rigorously reviewed in close association with faculty experts in tobacco research at the Section of Pulmonary and Critical Care Medicine at AKUH. Content validity was assessed by calculating a content validity index (CVI) for this survey for relevance, essentiality and clarity based on the ratings of two subject experts. A CVI of 0.942, 0.942 and 0.8986 was calculated for these three parameters respectively, which was deemed acceptable according to Davis (1992) (\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThe final survey contained four sections which were demographics, knowledge, attitudes, and usage. The survey began with a consent form explaining the nature and scope of the survey and then the sections were asked from the respondents.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003e\u003cb\u003eSample Size Calculation and Sampling Technique\u003c/b\u003e\u003c/h2\u003e \u003cp\u003eThe sample size was calculated using OpenEpi(\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e). According to the Pakistan Demographic and Health Survey 2017-18, the current smoking prevalence among men ages 15\u0026ndash;49 is 31.8%(\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e). Using that statistic, at least 334 participants aged 18 years and above were determined to be recruited. An additional 10% margin of error was taken for a minimum required sample size of 367.\u003c/p\u003e \u003cp\u003eFor this study, convenience sampling was used to reach adults across the country. The online questionnaire was shared on social media platforms and circulated from person to person.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003eSampling Technique and Data Collection Procedure\u003c/h2\u003e \u003cp\u003eResponses were collected by means of a questionnaire that was available in both English and Urdu, the national language of Pakistan. Our questionnaire was circulated among adults (age\u0026thinsp;\u0026ge;\u0026thinsp;18) as a Google Form, on closed social media platforms, such as WhatsApp groups and Facebook groups.\u003c/p\u003e \u003cp\u003eAs the data was collected, it was compiled into a Google Sheet. This Google Sheet was password protected and accessible only to members of the research team. Upon completion of data collection, the Google Sheet was downloaded as an Excel sheet, which was password protected. The Google Sheet and individual questionnaire responses were available to the research team for 3 months after data collection was complete, after which they were erased.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec7\" class=\"Section2\"\u003e \u003ch2\u003eStatistical Analysis\u003c/h2\u003e \u003cp\u003eStatistical analyses were run using Statistical Package for Social Sciences (SPSS) version 26. Continuous data such as age were reported using mean and standard deviation. Categorical data consisting of the results of the Likert scales and multiple-choice questions has been reported as frequencies (gross numbers) and percentages (n; %). To analyze the effect of factors such as age, sex, and level of education on the overall knowledge score, a linear regression was performed. In addition, a logistic regression analysis was undertaken to determine significant motivating and deterring factors. A p-value of \u0026lt;\u0026thinsp;0.05 was considered significant for all analyses.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eDemographics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe collected data from a total of 1,195 participants. The median age of the participants stood at 23 years, and there was a fair distribution of gender, with 41.75% identifying as male and 58.24% as female. Geographically, the majority hailed from Sindh (42.09%) and Punjab (32.30%), while other provinces were represented to a lesser degree as displayed in \u003cstrong\u003eFigure 1\u003c/strong\u003e. Ethnically, the largest contingent identified as Urdu speaking (29.29%), followed by Punjabi (22.51%), and Pashtun (17.49%). Educational levels varied, with 62.59% holding bachelor's degrees and 26.11% possessing postgraduate degrees. Most of the respondents were unmarried (79.83%), while monthly income majorly ranged from PKR 100,000 to 500,000 (43.26%) and PKR 50,000 to 100,000 (26.69%). Additionally, the majority reported visiting a healthcare provider 1-2 times in the past 12 months (50.63%). These data have been summarized in \u003cstrong\u003eTable 1\u003c/strong\u003e.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eKnowledge Towards SLTs\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMost participants (85.86%) demonstrated prior awareness of smokeless tobacco before the survey. When questioned about the contents of smokeless tobacco, 51.38% believed it contained both tobacco and nicotine, 20.92% believed it contained only nicotine, and 16.49% believed it contained only tobacco. Approximately 5% of participants held the view that neither substance was present. In terms of perceptions of harm, 54.23% believed that smokeless tobacco is equally harmful as traditional cigarettes, while 25.27% considered it less harmful, and 17.82% deemed it more harmful. A minor percentage (2.68%) perceived it to be not harmful at all. Notably, 43.68% believed these products were not prohibited by law, and 30.29% were uncertain about their legal status as displayed in \u003cstrong\u003eFigure 2\u003c/strong\u003e.\u003c/p\u003e\n\u003cp\u003eConcerning health risks, 72.55% concurred that these products can lead to serious illnesses such as cancer and stroke. In addition, a majority disagreed with the notion that occasional use of these products is non-addictive or harmless, with 30.63% expressing strong disagreement. Meanwhile, 22.85% believed these products assist in quitting cigarettes, and 27.53% adopted a neutral stance on the matter. Finally, a substantial proportion, 63.26%, strongly disagreed that these products are safe during pregnancy, and 62.59% strongly disagreed that they are safe for individuals with underlying medical conditions such as heart disease, blood pressure, and diabetes as displayed in \u003cstrong\u003eFigure 3\u003c/strong\u003e.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eOn linear regression analysis (\u003cstrong\u003eTable 2\u003c/strong\u003e) to determine significant factors affecting knowledge, females had greater odds to higher knowledge\u0026nbsp;scores, respondents from Punjab\u0026nbsp;had 33% lower odds of higher knowledge compared to respondents from Sindh. Higher monthly household income (1.8 times greater odds of the 100,000-500,000 group) and doctor visits (greater than 1) both were associated with greater odds of higher knowledge scores.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAttitudes towards SLTs\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eConcerning attitudes toward smokeless tobacco, a significant majority either disagreed or strongly disagreed that it makes one happy (65.78%) and feel young (69.62%). Conversely, participants agreed or strongly agreed that the use of these products could lead to feeling unwell or sick (44.10%) and evoke a sense of shame or guilt (43.85%). Interestingly, the majority also expressed disagreement or strong disagreement with the notion that these products are exclusive to adults (44.77%) and that the health effects are genetic and don't happen to everyone (67.03%). Additionally, a substantial number of participants (54.39%) believed that further research on these products is required. These data are summarized in \u003cstrong\u003eFigure 4\u003c/strong\u003e.\u003c/p\u003e\n\u003cp\u003eWe investigated the influence of various motivators on prompting individuals to consider or adopt smokeless tobacco products as shown in \u003cstrong\u003eFigure 5\u003c/strong\u003e. Notably, the most substantial impact was attributed to the perception that these products aid in stress reduction, with 25.36% of participants acknowledging a significant impact. Furthermore, the pleasurable experience offered by these products had a significant impact on 22.68% of respondents, and the ease of acquisition played a significant impact on 23.60%. Motivations such as favorite flavors (46.95%) and the absence of offensive odors or pleasant smells (45.78%) were influential. Social factors were also relevant, as having friends or family members using these products (20.33%) and the perception of appearing \"cool\" (17.57%) held a significant impact. Positive media portrayals (19.08%) and the perception of these products as an alternative to cigarettes (20.17%) were additional contributors to motivation.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAn evaluation of various deterrents discouraging individuals from embracing smokeless tobacco products revealed notable impacts. Foremost among these deterrents was the concern about the negative health effects of the product, as reported by 60.33% of participants. Similarly, the social unacceptability or stigma associated with these products had a significant impact on 45.57% of respondents. 33.14% respondents claimed that cost factor played a significant role in deterring them from using these products. Factors such as negative taste and smell (48.20%), environmental pollution (41.76%), and the potential spread of secondhand smoke to family and friends (46.11%) emerged as demotivators. Additionally, a significant percentage expressed that the fear of addiction (56.07%) and opposition from family members and friends (51.05%) had a significant impact in not pursuing them. These data have been displayed in \u003cstrong\u003eFigure 6\u003c/strong\u003e.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eUsage of SLTs\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn terms of usage, a total of 30.54% of respondents acknowledged having used smokeless tobacco products at least once, while the majority (69.46%) had not. Among past users of SLTs, 20.92% used it daily, while the majority used it less than daily (47.96%). In comparison, 31.95% of current users used SLTs daily while 35.50% used it less than daily. Concerning intentions to quit, 69.82% of current users expressed a desire to quit, while 30.18% indicated no plans to quit. These data have been summarized in \u003cstrong\u003eTable 3\u003c/strong\u003e.\u003c/p\u003e\n\u003cp\u003eOn logistic regression (\u003cstrong\u003eTable 4\u003c/strong\u003e) to determine significant factors influencing the use of SLTs, the greatest odds of use were found with use as an alternative to cigarettes (OR 4.45) and secondly, due to its availability in a liked flavor (OR 2.27). Respondents who felt SLTs made them look cool had lesser odds of using them at least once (OR 0.58). No significant deterrents were found to influence SLT use.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eOur study finds that the majority of the participants had heard of SLTs prior to the study and had a fair degree of knowledge regarding the product content and health effects, with negative health impact being a significant deterrent to use. It is to be noted that the laws pertaining to SLTs were debated among respondents and attitudes leaned towards the negative side. Motivating factors included as an alternative to cigarettes, outlook of the drug on perceived popularity and widespread availability in flavors. The utilization of SLTs presents an escalating public health issue, with approximately 360\u0026nbsp;million individuals worldwide engaging in its consumption, predominantly concentrated in the South Asian region where over 90% of users reside(\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e). Despite its well-understood association with various disease states, the prevalence of SLTs is steadily increasing within South Asian nations (\u003cspan additionalcitationids=\"CR29\" citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eMore than half the participants answered the composition of SLTs correctly, while at the same time a surprising 21% believed it contained only nicotine and 16.5% thought SLTs had tobacco only. The common forms of smokeless tobacco in Pakistan include Naswar, Chalia, Pan (betel with tobacco), and Gutka(\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e). All of these compositions contain tobacco with varying degrees of nicotine based on regional preferences. A survey on rural Bangladeshi adolescents revealed that 32.5% of the participants did not know SLTs contain nicotine, and according to the Bangladesh Global Adult Tobacco Survey 2015, 58% of the non-users implicated that SLTs contain nicotine(\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e, \u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e). Although lack of prior study examining the public's knowledge of SLTs ingredients in Pakistan, hindered direct comparison, our findings are comparable to the available data.\u003c/p\u003e \u003cp\u003eConcerning health risks, 72.55% of our respondents concurred that these products can lead to serious illnesses such as cancer and stroke. One study from Karachi, Pakistan, revealed that 44% males and 37% females thought it is bad for health. 54% of our survey participants believed that SLTs are equally harmful, and 25% believed they are less harmful compared to traditional cigarettes(\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e). This statistic is in accordance with a previous study conducted in Poland, which demonstrated that 72% of their respondents perceived SLTs to be as harmful and 25% to be less harmful than cigarettes (\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e). Another survey from Bangladesh revealed that only one-quarter of their participants thought SLTs were less harmful than smoked tobacco(\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e). The perceived severity of SLTs compared to traditional smoked cigarettes is low among our participants, thereby contributing to a higher likelihood of individuals choosing to use smokeless tobacco (\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eEmotional associations with smokeless tobacco were also explored in detail in our study. Participants' rejection of the notion that SLT use evokes a sense of feeling happy or young likely reflects an increasing awareness of the health risks associated with smokeless tobacco consumption (\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e, \u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e). This shift in perception underscores societal attitudes, indicating a growing understanding of its adverse effects on health and well-being. Respondents associated a sense of guilt and unwellness with smokeless tobacco use likely stems from societal efforts to promote tobacco cessation, and it may contribute to individuals feeling morally conflicted and physically unwell when using smokeless tobacco products.\u003c/p\u003e \u003cp\u003eThe majority of our respondents disagreed that smokeless tobacco products are exclusively for adults. In recent years, a shift from smoked tobacco products to SLTs is seen among the younger population in Western countries (\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e). A survey noted that more than 300 kids ages 12\u0026ndash;17 started using smokeless tobacco for the first time in the US(\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e). The drift towards smokeless tobacco in the South Asian younger population is also in the process. A recent study from India revealed that the majority of students initiating SLTs were in the 10\u0026ndash;11 years age group, and 11% of the students enrolled in classes 9\u0026ndash;11 were consuming SLTs (\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e). The availability and accessibility of smokeless tobacco products, coupled with limited regulatory measures, contribute to their widespread use among younger populations (\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e Exploring the factors in encouraging the use of SLTs in our participants, we found that the perception of SLTs as a stress reliever, pleasurable experience after the use of these products, and ease of acquisition played a crucial role. A grounded theory study conducted in Iran, similarly, revealed that along with the addictive nature of SLTs, relaxation and euphoria were some of the prominent continuation factors(\u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e43\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eEase of acquisition and unregulated distribution play a pivotal role in the widespread prevalence of these products in the South Asian region(\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e, \u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e45\u003c/span\u003e). Naswar, a common form of SLT is widely available in 20g packing costing 10 Pakistani rupees (US\u003cspan\u003e$\u003c/span\u003e0.04), which can be consumed several times a day (\u003cspan citationid=\"CR46\" class=\"CitationRef\"\u003e46\u003c/span\u003e, \u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e47\u003c/span\u003e). Social influences from friends and family members who use smokeless tobacco products can normalize and promote their usage among the population, particularly among young individuals who may be influenced by peer behavior(\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e). Positive media representations of SLTs and their portrayal as an alternative to cigarettes can shape public perception, influencing individuals to perceive these products as attractive and potentially safer alternatives.\u003c/p\u003e \u003cp\u003ePertinent factors in discouraging the use of SLTs in our respondents included negative health effects. Previous studies have demonstrated that the harmful health impacts of SLTs serve as the main deterrent(\u003cspan citationid=\"CR49\" class=\"CitationRef\"\u003e49\u003c/span\u003e). The stigma attached to SLTs and the fear of addiction act as significant deterrents among our participants. The stigma stems from societal perceptions of these products as unappealing or undesirable, leading to fear of being judged, hence avoiding their use altogether. The fear of addiction underscores apprehensions about the long-term consequences of tobacco use, further discouraging its uptake.\u003c/p\u003e \u003cp\u003eA minority of respondents reported having used SLTs before, although higher than previous reports of 19\u0026ndash;21% prevalence(\u003cspan citationid=\"CR50\" class=\"CitationRef\"\u003e50\u003c/span\u003e). This is likely attributable to our sample having a greater degree of education and being primarily from the young adult age group. Previous studies have found associations with SLT use and age, with highest prevalence in the 30\u0026ndash;39 age group and lowest in those with the highest level of education(\u003cspan citationid=\"CR51\" class=\"CitationRef\"\u003e51\u003c/span\u003e). Future studies should be translated into regional languages of Sindhi, Pashto, Balochi and Seraiki and venture into rural areas of Pakistan and places where our web-based survey was unable to reach.\u003c/p\u003e \u003cp\u003eOf particular note in the patterns of use was that daily usage of SLTs had decreased from past to current users, signifying decreased initiative in procuring the product. A reason for this could be the warning given in tobacco packaging(\u003cspan citationid=\"CR52\" class=\"CitationRef\"\u003e52\u003c/span\u003e). This impact can further be enhanced by ensuring the inclusion of all STP kinds in the law and further increasing the degree of warning provided on packaging, a challenge the government continues to face(\u003cspan citationid=\"CR53\" class=\"CitationRef\"\u003e53\u003c/span\u003e). This serves to show that interventions, if conducted in a proper manner have the potential to give results.\u003c/p\u003e \u003cdiv id=\"Sec14\" class=\"Section2\"\u003e \u003ch2\u003eStrengths\u003c/h2\u003e \u003cp\u003eThis study is first of its kind in this region to inquire on knowledge, attitudes and usage of SLTs in Pakistan and has the potential to pave the way for future research along with facilitating the development of policy. This study includes a new web based comprehensive questionnaire which was developed using elements from the Global Adult Tobacco Survey (GATs) and considerate reviewing was done to increase reliability of the questionnaire. An adequate sample size of 1195 participants were used, which increased the power of the statistical test.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec15\" class=\"Section2\"\u003e \u003ch2\u003eLimitations\u003c/h2\u003e \u003cp\u003eThe uneven representation throughout provinces is a crucial finding that highlights the need for more study to fully understand the various regional variations in the use of smokeless tobacco. Moreover, most of the study's sample comprises persons with greater educational attainment, potentially skewing the findings and limiting their generalizability to the broader population. Additionally, as one of the pioneering investigations into SLT use in Pakistan with a substantial sample size, the study lacks comparative data from similar studies, hindering the ability to contextualize its findings. Our study focuses on younger university students who have a greater awareness of health risks and are more impacted by social stigma. This limits our ability to identify accurate deterrents for smokeless tobacco (SLT) use within this group and highlights the need for further research on factors influencing SLT use in a broader population.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec16\" class=\"Section2\"\u003e \u003ch2\u003eStudy Recommendations\u003c/h2\u003e \u003cp\u003eSLTs have been in the tobacco market for a long-time making interventions to reduce use a public health priority. Public interventions should aim to reduce accessibility to the product while continuing to promote public awareness campaigns on the health risks of chewing tobacco. By making SLTs less inexpensive, greater taxes can discourage use. In order to restrict advertising and accessibility, it is also crucial to enforce strict marketing laws. In addition, with the emergence of branded forms of SLTs, monitoring of marketing is important to prevent early age exposure. Equally important is packaging, which can reduce attraction and warn consumers of potential hazards by requiring plain packaging with health warnings. Campaigns directed by the government should encourage cessation support, and marketing efforts should be evidence-based and highlight health risks.\u003c/p\u003e \u003c/div\u003e"},{"header":"Conclusions","content":"\u003cp\u003eIn summary, our research contributes to a better understanding of SLTs in Pakistan. Our findings underscore the urgent need for targeted public health interventions to address misconceptions, deter use, and promote cessation efforts in the face of an escalating public health issue. SLTs have been within public use in the form of chewable tobacco for a long time, however the emergence of newer varieties requires policy intervention to regulate usage. By identifying key misconceptions, motivations, and deterrents, we provide valuable insights that can inform the development of targeted interventions aimed at reducing smokeless tobacco use and its associated health risks in the Pakistani population.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eSmokeless tobacco (SLT)\u003c/p\u003e\n\u003cp\u003eStrengthening the Reporting of Observational Studies in Epidemiology (STROBE)\u003c/p\u003e\n\u003cp\u003eAga Khan University Hospital\u0026apos;s (AKUH)\u003c/p\u003e\n\u003cp\u003eEthical Review Committee (ERC)\u003c/p\u003e\n\u003cp\u003eGlobal Adult Tobacco Survey (GATs)\u003c/p\u003e\n\u003cp\u003eContent validity index (CVI)\u003c/p\u003e\n\u003cp\u003eStatistical Package for Social Sciences (SPSS)\u003c/p\u003e\n\u003cp\u003eInterquartile range (IQR)\u003c/p\u003e\n\u003cp\u003ePakistani Rupees (PKR)\u003c/p\u003e\n\u003cp\u003eOdds Ratio (OR)\u003c/p\u003e\n\u003cp\u003eAga Khan University (AKU)\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eOur study obtained ethical clearance from the Ethical Review Committee (ERC) at the Aga Khan University (ID: 2023-8608-24823). The form initially obtained informed consent, detailing the scope of the study, the right of the participant to withdraw from the study at any time and the maintenance of confidentiality of the participants. If the participant agreed to take part in the study, they were able to fill the rest of the questionnaire. To maintain the privacy of the participants, identifiers such as name were not asked. In addition, to maintain anonymity, the questionnaire did not record respondents\u0026rsquo; names. There were no risks, immediate benefits, or incentives for participation in the survey.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAdditional data is available on reasonable request from the corresponding author. Please note that all data has been provided in the manuscript.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003cbr\u003e\u0026nbsp;\u003c/strong\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNone.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eHAI, NI and JAK conceptualized the study and devising the methodology. US, WAS, AS and SR were instrumental in the data collection and recruitment of participants by disseminating the questionnaire, while HAI, HJ, and SARM were the major contributors in analyzing and interpreting data. HAI, US, MS and WAS contributed to the initial draft while HAI, HJ and SARM were major contributors in editing the manuscript. HAI, HJ, and SARM critically reviewed the results and suggested changes. All authors approved of the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors express their gratitude to the Aga Khan University (AKU) Section of Pulmonary and Critical Care Medicine, specifically to Dr. Talha Shahzad for his assistance in creating the study instrument and Ms. Rubeena Irfan for her administrative support. We would also like to thank Muhammad Ali Akbar Khan (AKU) and Taha Shaikh (AKU) for reviewing the final manuscript.\u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eWHO - types of tobacco use [Internet]. [cited 2024 Apr 15]. Available from: https://www.afro.who.int/sites/default/files/2017-09/Chapter%201.%20Types%20of%20tobacco%20use_1.pdf\u003c/li\u003e\n\u003cli\u003eWHO EMRO | Smokeless tobacco consumption in a multi-ethnic community in Pakistan: a cross-sectional study | Volume 20, issue 6 | EMHJ volume 20, 2014 [Internet]. 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Lancet Respir Med. 2015 Sep;3(9):673. \u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"100%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eTable 1: Demographics Characteristics\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u003cem\u003eIQR: Interquartile range; N=1195\u003c/em\u003e\u003c/p\u003e\n \u003cp\u003e*IQR has been reported as (Q1 \u0026ndash; Q3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eVariable\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003en (%)/Median (IQR)*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eAge (Years)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e23 (5)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eSex\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e499 (41.75)\u003c/p\u003e\n \u003cp\u003e696 (58.24)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eProvince of residence\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eSindh\u0026nbsp;\u003c/p\u003e\n \u003cp\u003ePunjab\u003c/p\u003e\n \u003cp\u003eKhyber Pakhtunkhwa\u003c/p\u003e\n \u003cp\u003eBalochistan\u003c/p\u003e\n \u003cp\u003eIslamabad Capital Territory\u003c/p\u003e\n \u003cp\u003eAzad Jammu and Kashmir\u003c/p\u003e\n \u003cp\u003eGilgit Baltistan\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e503 (42.09)\u003c/p\u003e\n \u003cp\u003e386 (32.30)\u003c/p\u003e\n \u003cp\u003e176 (14.73)\u003c/p\u003e\n \u003cp\u003e52 (4.35)\u003c/p\u003e\n \u003cp\u003e48 (4.02)\u003c/p\u003e\n \u003cp\u003e25 (2.09)\u003c/p\u003e\n \u003cp\u003e5 (0.42)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eCity of residence\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eKarachi\u003c/p\u003e\n \u003cp\u003eLahore\u0026nbsp;\u003c/p\u003e\n \u003cp\u003ePeshawar\u003c/p\u003e\n \u003cp\u003eBahawalpur\u003c/p\u003e\n \u003cp\u003eIslamabad\u003c/p\u003e\n \u003cp\u003eQuetta\u003c/p\u003e\n \u003cp\u003eRawalpindi\u003c/p\u003e\n \u003cp\u003eHyderabad\u003c/p\u003e\n \u003cp\u003eMultan\u003c/p\u003e\n \u003cp\u003eGujrat\u003c/p\u003e\n \u003cp\u003eTando Allahyar\u003c/p\u003e\n \u003cp\u003eFaisalabad\u003c/p\u003e\n \u003cp\u003eRahim Yar Khan\u003c/p\u003e\n \u003cp\u003eGujranwala\u003c/p\u003e\n \u003cp\u003eMuzaffarabad\u003c/p\u003e\n \u003cp\u003eGhotki\u003c/p\u003e\n \u003cp\u003eAbbottabad\u003c/p\u003e\n \u003cp\u003eCharsadda\u003c/p\u003e\n \u003cp\u003eNarowal\u003c/p\u003e\n \u003cp\u003eDera Ismail Khan\u003c/p\u003e\n \u003cp\u003eMirpur Khas\u003c/p\u003e\n \u003cp\u003eOther \u0026nbsp;\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e434 (36.32)\u003c/p\u003e\n \u003cp\u003e130 (10.88)\u003c/p\u003e\n \u003cp\u003e128 (10.71)\u003c/p\u003e\n \u003cp\u003e65 (5.44)\u003c/p\u003e\n \u003cp\u003e57 (4.77)\u003c/p\u003e\n \u003cp\u003e51 (4.27)\u003c/p\u003e\n \u003cp\u003e46 (3.85)\u003c/p\u003e\n \u003cp\u003e33 (2.76)\u003c/p\u003e\n \u003cp\u003e23 (1.92)\u003c/p\u003e\n \u003cp\u003e18 (1.51)\u003c/p\u003e\n \u003cp\u003e13 (1.09)\u003c/p\u003e\n \u003cp\u003e11 (0.92)\u003c/p\u003e\n \u003cp\u003e10 (0.84)\u003c/p\u003e\n \u003cp\u003e9 (0.75)\u003c/p\u003e\n \u003cp\u003e9 (0.75)\u003c/p\u003e\n \u003cp\u003e8 (0.67)\u003c/p\u003e\n \u003cp\u003e7 (0.59)\u003c/p\u003e\n \u003cp\u003e7 (0.59)\u003c/p\u003e\n \u003cp\u003e7 (0.59)\u003c/p\u003e\n \u003cp\u003e5 (0.42)\u003c/p\u003e\n \u003cp\u003e5 (0.42)\u003c/p\u003e\n \u003cp\u003e119 (9.96)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eEthnicity\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003ePunjabi\u0026nbsp;\u003c/p\u003e\n \u003cp\u003eUrdu-speaking\u003c/p\u003e\n \u003cp\u003eSindhi\u003c/p\u003e\n \u003cp\u003ePashtun\u0026nbsp;\u003c/p\u003e\n \u003cp\u003eBaloch\u003c/p\u003e\n \u003cp\u003eMixed\u003c/p\u003e\n \u003cp\u003eOther\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e269 (22.51)\u003c/p\u003e\n \u003cp\u003e350 (29.29)\u003c/p\u003e\n \u003cp\u003e156 (13.05)\u003c/p\u003e\n \u003cp\u003e209 (17.49)\u003c/p\u003e\n \u003cp\u003e19 (1.59)\u003c/p\u003e\n \u003cp\u003e52 (4.35)\u003c/p\u003e\n \u003cp\u003e140 (11.72)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eLevel of Education\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u0026lt;5 years (Primary school)\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e5-10 years (Matric/ O Level)\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e10-12 years (Intermediate/ A Level)\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e12-14 years (Bachelor\u0026rsquo;s degree)\u003c/p\u003e\n \u003cp\u003e\u0026gt;14 years (Postgraduate degree)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e2 (0.17)\u003c/p\u003e\n \u003cp\u003e9 (0.75)\u003c/p\u003e\n \u003cp\u003e124 (10.38)\u003c/p\u003e\n \u003cp\u003e748 (62.59)\u003c/p\u003e\n \u003cp\u003e312 (26.11)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eMarital Status\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eUnmarried\u003c/p\u003e\n \u003cp\u003eMarried\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e954 (79.83)\u003c/p\u003e\n \u003cp\u003e241 (20.17)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eMonthly Family Income (PKR)\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u0026lt; 25,000\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e25,000-50,000\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e50,000-100,000\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e100,000-500,000\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e\u0026gt; 500,000\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e69 (5.77)\u003c/p\u003e\n \u003cp\u003e118 (9.87)\u003c/p\u003e\n \u003cp\u003e319 (26.69)\u003c/p\u003e\n \u003cp\u003e517 (43.26)\u003c/p\u003e\n \u003cp\u003e172 (14.39)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"44.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eHow many times did you visit a doctor or health care provider in the past 12 months?\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e0\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e1 or 2\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e3 to 5\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e6 or more\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"55.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e272 (22.76)\u003c/p\u003e\n \u003cp\u003e605 (50.63)\u003c/p\u003e\n \u003cp\u003e218 (18.24) \u0026nbsp;\u003c/p\u003e\n \u003cp\u003e100 (8.37)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"100%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003ePKR (Pakistani Rupees); IQR (Interquartile range)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:12.0pt;margin-bottom:15.0pt;font-size:11.0pt;text-align:justify;line-height:200%;'\u003e\u003cspan style=\"color:black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width:100.0%;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" style=\"width: 100%;border: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eTable 2: Linear Regression to Determine Factors affecting Knowledge regarding SLTs\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 51.82%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eVariable\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOdds Ratio\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eP-Value\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 51.82%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAge (years)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.295\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 51.82%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eSex\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eFemale\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 (reference)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.73\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:red;'\u003e0.004*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 51.82%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eLevel of Education\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNo formal education\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;5 years (Primary school)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e5-10 years (Matric/ O level)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e10-12 years (Intermediate/ A level)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e12-14 years (bachelor\u0026rsquo;s degree)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026gt;14 years (Postgraduate degree)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 (reference)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e5.52\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e24.12\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e25.37\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e17.82\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e17.74\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.607\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.174\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.115\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.137\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.146\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 51.82%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMarital Status\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eUnmarried\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMarried\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eDivorced\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eWidowed\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 (reference)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.92\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2.91\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2.34\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.557\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0677\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.533\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 51.82%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eProvince of Residence\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eSindh\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAJK\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eBalochistan\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eGilgit Baltistan\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIslamabad Capital Territory\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eKPK\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePunjab\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 (reference)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.91\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.79\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2.64\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.84\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.02\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.806\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.363\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.233\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.534\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.888\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:red;'\u003e0.001*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 51.82%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMonthly Household Income (PKR)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;25,000\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e25,000-50,000\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e50,000-100,000\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e100,000-500,000\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026gt;500,000\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 (reference)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.76\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.09\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.80\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.45\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.736\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.207\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:red;'\u003e0.007*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.159\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 51.82%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNumber of Doctor Visits in Past 12 Months\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 or 2\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e3 to 5\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e6 or more\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1 (reference)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.97\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.24\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.93\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 24.08%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:red;'\u003e0.03*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.797\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.094\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"100%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eTable 3: Usage of SLTs\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u003cem\u003eN=1195\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"80.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eVariable\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003en (%)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"80.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eHave you ever used any type\u0026nbsp;of SLTs, even once?\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e365 (30.54)\u003c/p\u003e\n \u003cp\u003e830 (69.46)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"100%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003eUsed SLTs at least once or currently using (N= 365)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"80.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eType of SLT or Similar Product Used (More than one may apply per respondent)\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eChewing\u0026nbsp;tobacco, such\u0026nbsp;as loose leaf, plug, twist roll\u003c/p\u003e\n \u003cp\u003eVELO/Oral Nicotine Pouches\u003c/p\u003e\n \u003cp\u003eSnuff/Naswar\u003c/p\u003e\n \u003cp\u003eLozenges\u003c/p\u003e\n \u003cp\u003eOrbs\u003c/p\u003e\n \u003cp\u003eSticks\u003c/p\u003e\n \u003cp\u003eStrips\u003c/p\u003e\n \u003cp\u003eOther\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e43 (11.78)\u003c/p\u003e\n \u003cp\u003e88 (24.11)\u003c/p\u003e\n \u003cp\u003e20 (5.48)\u003c/p\u003e\n \u003cp\u003e13 (3.56)\u003c/p\u003e\n \u003cp\u003e6 (1.64)\u003c/p\u003e\n \u003cp\u003e7 (1.92)\u003c/p\u003e\n \u003cp\u003e7 (1.92)\u003c/p\u003e\n \u003cp\u003e14 (3.84)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"100%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003ePast Users of SLTs (N= 196)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"80.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eHow often did you use smokeless tobacco products in the past?\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eDaily\u003c/p\u003e\n \u003cp\u003eLess than daily\u003c/p\u003e\n \u003cp\u003eDon\u0026apos;t know\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e41 (20.92)\u003c/p\u003e\n \u003cp\u003e94 (47.96)\u003c/p\u003e\n \u003cp\u003e61 (31.12)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"100%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003eActive Users of SLTs (N=\u0026nbsp;169)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"80.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eHow much do you currently spend on it\u0026nbsp;per week? (PKR)\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u0026lt; 1000\u003c/p\u003e\n \u003cp\u003e1000 - 2000\u003c/p\u003e\n \u003cp\u003e2000 - 3000\u003c/p\u003e\n \u003cp\u003e\u0026gt; 3000\u003c/p\u003e\n \u003cp\u003eDon\u0026rsquo;t know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e45 (26.63)\u003c/p\u003e\n \u003cp\u003e25 (14.79)\u003c/p\u003e\n \u003cp\u003e10 (5.91)\u003c/p\u003e\n \u003cp\u003e19 (11.24)\u003c/p\u003e\n \u003cp\u003e70 (41.42)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"80.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eHow often do you use smokeless tobacco products currently?\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eDaily\u003c/p\u003e\n \u003cp\u003eLess than daily\u003c/p\u003e\n \u003cp\u003eDon\u0026apos;t know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e54 (31.95)\u003c/p\u003e\n \u003cp\u003e60 (35.50)\u003c/p\u003e\n \u003cp\u003e55 (32.54)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"80.76923076923077%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eDo you plan on quitting?\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.23076923076923%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e118 (69.82)\u003c/p\u003e\n \u003cp\u003e51 (30.18)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"100%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003eAbbreviations used: PKR (Pakistani Rupees), SLT (Smokeless Tobacco)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003ctable style=\"width:102.42%;margin-left:-5.65pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" style=\"width: 100%;border: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eTable 4: Logistic Regression to Determine Factors Influencing the Use of SLTs At Least Once\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e*Adjusted for Age, Gender, Province, Ethnicity, Marital Status, Level of Education and Monthly Family Income\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eVariable\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOdds Ratio\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eP -Value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" style=\"width: 100%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMotivators\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eEasy to acquire\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.68\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.181\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eEnjoyable experience\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.746\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eGets rid of stress\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.92\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.800\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eComes in flavors I like\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e2.27\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:red;'\u003e0.008*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNo offensive odor\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.33\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.317\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eA friend/family member uses\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.93\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.803\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIt makes one look cool\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.58\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:red;'\u003e0.032*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePositively portrayed in media\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.77\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.326\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAlternative to cigarettes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e4.45\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:red;'\u003e\u0026lt;0.001*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eCheaper than others\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.891\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" style=\"width: 100%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eDeterrents\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNegative health effects\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.93\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.816\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNot socially acceptable\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.64\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.103\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eExpensive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.88\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.601\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eBad taste/smell\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.71\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.182\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eEnvironmental pollution\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.94\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.821\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eSecond hand spread to family\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.82\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.485\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eDo not want to get addicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.576\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNegative portrayal in media\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.82\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.478\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eDifficult to acquire\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.85\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.534\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 33.34%;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOpposed by family and friends\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.34%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e1.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.32%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.888\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"chewed tobacco, public health, snus, non-cigarette","lastPublishedDoi":"10.21203/rs.3.rs-4724727/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4724727/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003e Smokeless tobacco (SLT) encompasses products that are not burnt but instead consumed orally or nasally. One-third of tobacco is consumed in the smokeless form in South Asia. Despite its widespread usage, there has been limited empirical research on the prevalence of and factors influencing SLT consumption in Pakistan. This study aimed to provide an assessment of SLT knowledge, attitudes, and usage in Pakistan.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eUsing an online questionnaire, a cross-sectional survey was conducted across Pakistan. Convenience sampling was used to disseminate, and expert approval was sought followed by a pilot study to validate the questionnaire. A comprehensive questionnaire was developed using elements from the Global Adult Tobacco Survey and other tools which had previously been utilized within Pakistan. Participants' responses were described using descriptive statistics, and SPSS version 26 was used to perform linear and logistic regression. A p-value of less than 0.05 was considered statistically significant.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eData was collected from 1,195 participants among which 85.86% of participants had heard of SLTs prior to the survey. Sex, province, household income and previous doctor visits were significant determinants to product knowledge through which 72.55% agreed that these products can lead to serious illnesses but 30% noted a lack of knowledge on legality. General attitudes agreed to a belief that it makes one unwell (44.1%), sense of guilt (43.85%) and more research is needed on it (54.39%). Negative health effects were the biggest deterrent from pursuing these products for 60.33% of participants. Among significant factors influencing the use of SLTs, the greatest odds of use were found with use as an alternative to cigarettes (OR 4.45) and secondly, due to its availability in a liked flavor (OR 2.27). About 31% reported to have used the product once, with 69.82% of current users expressing a desire to quit.\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eAlthough adequate knowledge and aligning attitudes exist for SLTs, light is shed in the face of a sustaining public health problem. We offer important insights that can guide the creation of focused interventions meant to lower SLT use, and the health hazards associated with it in the Pakistani community by highlighting important myths, incentives, and deterrents.\u003c/p\u003e","manuscriptTitle":"No Smoke Left Behind- Knowledge, Attitudes and Usage of Smokeless Tobacco from the Lens of the Public: A Nationwide Cross-Sectional Study from Pakistan","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-08-11 12:18:29","doi":"10.21203/rs.3.rs-4724727/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f5f9d654-d012-4819-8dae-26527104cd75","owner":[],"postedDate":"August 11th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-08-16T11:02:19+00:00","versionOfRecord":[],"versionCreatedAt":"2024-08-11 12:18:29","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4724727","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4724727","identity":"rs-4724727","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}