Future Research Strategies and Directions in Recurrent Pregnancy Loss

Recurrent pregnancy loss is defined as two or more consecutive pregnancy losses in the first or early second trimester. Most of research in area of unexplained factors is based on maternal factors such as meiotic error, oocyte quality, obesity, uterine architecture, metabolic factors, infection and immunology. Future directions in investigating biomolecular risk factors include integrating alternative approaches (DNA variants, gene and protein expression, epigenetic regulation) in genetic studies and newer molecular markers such as leptin, IL-1, IL-8 and TNF alfa and assessment of markers for endometrial receptivity and implantation. Newer therapeutic interventions include monoclonal antibodies against the TNF-α molecule (adalimumab) or against soluble TNF-α receptors (etanercept), G-CSF and Vitamin D supplementation. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis. 2011;70:145–50. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2018 Springer Nature Singapore Pte Ltd. About this chapter Cite this chapter Bhaskaran, S., Suneja, A. (2018). Future Research Strategies and Directions in Recurrent Pregnancy Loss. In: Mehta, S., Gupta, B. (eds) Recurrent Pregnancy Loss. Springer, Singapore. https://doi.org/10.1007/978-981-10-7338-0_22 Download citation DOI: https://doi.org/10.1007/978-981-10-7338-0_22 Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-10-7337-3 Online ISBN: 978-981-10-7338-0 eBook Packages: MedicineMedicine (R0)

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