Quantitative Optimization of Heating Element for Enhanced Temperature Uniformity in an Embryo Chamber 

Quantitative Optimization of Heating Element for Enhanced Temperature Uniformity in an Embryo Chamber | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Quantitative Optimization of Heating Element for Enhanced Temperature Uniformity in an Embryo Chamber Yu Song, Weijun Zeng, Donggen Xiao, Zhenying Zhao, Haixuan Sun This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4813324/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In assisted reproductive technology (ART), maintaining a uniform temperature field within the culture space is critical for ensuring consistent embryo development quality. Traditional heating element designs often overlook the heat transfer characteristics of the system, resulting in significant temperature variations across the culture space. This study introduces a quantitative optimization approach for heating element, focusing on metal foil as a case study, to enhance temperature uniformity in the embryo chamber. A fluid-structure coupled heat transfer model was developed, and numerical simulations were conducted to analyze temperature distributions under various heating element layouts and parameters. After achieving heat transfer equilibrium, the culture chamber structure was segmented into multiple isothermal regions, applying the law of energy conservation to establish the relationship between changes in heating element resistance and temperature within each region. Adjusting the length or width of the metal foil in different areas optimized the temperature distribution of the overall structure, thereby improving the uniformity of the temperature field within the embryo chamber. Experimental results suggest that the optimized heating element reduce the temperature gradient within the culture chamber from 0.5 ℃ to less than 0.1 ℃, offering robust technical support for enhancing embryo development quality and consistency. Physical sciences/Engineering Physical sciences/Engineering/Biomedical engineering Physical sciences/Engineering/Mechanical engineering Embryo culture Culture chamber Metal foil Temperature uniformity Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4813324","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":350591385,"identity":"638ff20c-7dbb-42d1-8920-e898b5666a79","order_by":0,"name":"Yu Song","email":"","orcid":"","institution":"Suzhou Institute of Biomedical Engineering and Technology","correspondingAuthor":false,"prefix":"","firstName":"Yu","middleName":"","lastName":"Song","suffix":""},{"id":350591386,"identity":"3f8c5fd1-4b7d-4931-946f-85445c8ee308","order_by":1,"name":"Weijun Zeng","email":"","orcid":"","institution":"Suzhou Institute of Biomedical Engineering and Technology","correspondingAuthor":false,"prefix":"","firstName":"Weijun","middleName":"","lastName":"Zeng","suffix":""},{"id":350591388,"identity":"6bce262f-e043-4a9a-8a98-f35fc909f5e6","order_by":2,"name":"Donggen Xiao","email":"","orcid":"","institution":"Suzhou Institute of Biomedical Engineering and Technology","correspondingAuthor":false,"prefix":"","firstName":"Donggen","middleName":"","lastName":"Xiao","suffix":""},{"id":350591390,"identity":"a2b7cce1-7266-41a5-b13e-6429e3774eb8","order_by":3,"name":"Zhenying Zhao","email":"","orcid":"","institution":"Suzhou Institute of Biomedical Engineering and Technology","correspondingAuthor":false,"prefix":"","firstName":"Zhenying","middleName":"","lastName":"Zhao","suffix":""},{"id":350591391,"identity":"3bc11cb5-8cfc-4ec5-ae3e-dc5cfe446b63","order_by":4,"name":"Haixuan Sun","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAv0lEQVRIiWNgGAWjYHACNgaGCgYeAxK1nAFpYSZFC2MbAwPxWuRn5B57zDuvTsacvf8Aw48aBnlzQloMbuSlG87cdpjHsucwA2PPMQbDnQ2EtEjkmEl83HaAx+BGMgMDbwNDgsEBgg4DakmcU8djcP8xA+NfYrQw3ADZ0sAMtIWZgZkoWwzOvDGTnHEM5Jdkg8MyxyQMNxB0WHuOmTRPTZ29OfvBhw/f1NjIE3YYMgAqliBF/SgYBaNgFIwCXAAAShI45mV5CmIAAAAASUVORK5CYII=","orcid":"","institution":"Suzhou Institute of Biomedical Engineering and Technology","correspondingAuthor":true,"prefix":"","firstName":"Haixuan","middleName":"","lastName":"Sun","suffix":""}],"badges":[],"createdAt":"2024-07-27 13:39:30","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4813324/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4813324/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":75084323,"identity":"92dc37bb-6059-4b0c-9fe7-1af678f6a1e5","added_by":"auto","created_at":"2025-01-30 09:46:56","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":825629,"visible":true,"origin":"","legend":"","description":"","filename":"ScientificReports0726.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4813324/v1_covered_828e67da-cdf6-45be-8a37-8b54edb4764f.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Quantitative Optimization of Heating Element for Enhanced Temperature Uniformity in an Embryo Chamber ","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Embryo culture, Culture chamber, Metal foil, Temperature uniformity","lastPublishedDoi":"10.21203/rs.3.rs-4813324/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4813324/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIn assisted reproductive technology (ART), maintaining a uniform temperature field within the culture space is critical for ensuring consistent embryo development quality. Traditional heating element designs often overlook the heat transfer characteristics of the system, resulting in significant temperature variations across the culture space. This study introduces a quantitative optimization approach for heating element, focusing on metal foil as a case study, to enhance temperature uniformity in the embryo chamber. A fluid-structure coupled heat transfer model was developed, and numerical simulations were conducted to analyze temperature distributions under various heating element layouts and parameters. After achieving heat transfer equilibrium, the culture chamber structure was segmented into multiple isothermal regions, applying the law of energy conservation to establish the relationship between changes in heating element resistance and temperature within each region. Adjusting the length or width of the metal foil in different areas optimized the temperature distribution of the overall structure, thereby improving the uniformity of the temperature field within the embryo chamber. Experimental results suggest that the optimized heating element reduce the temperature gradient within the culture chamber from 0.5 ℃ to less than 0.1 ℃, offering robust technical support for enhancing embryo development quality and consistency.\u003c/p\u003e","manuscriptTitle":"Quantitative Optimization of Heating Element for Enhanced Temperature Uniformity in an Embryo Chamber ","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-09-11 06:44:06","doi":"10.21203/rs.3.rs-4813324/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c3f84564-adff-4637-ad35-17b5fa1040db","owner":[],"postedDate":"September 11th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":37226126,"name":"Physical sciences/Engineering"},{"id":37226127,"name":"Physical sciences/Engineering/Biomedical engineering"},{"id":37226128,"name":"Physical sciences/Engineering/Mechanical engineering"}],"tags":[],"updatedAt":"2025-01-30T09:38:39+00:00","versionOfRecord":[],"versionCreatedAt":"2024-09-11 06:44:06","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4813324","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4813324","identity":"rs-4813324","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}