The discriminators of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis in children

The discriminators of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis in children | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 31 December 2025 V1 Latest version Share on The discriminators of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis in children Authors : Xianfei Gao , Caihong Xu , Xi Lu , Danping Huang , Mingqi Zhao , Yifan Liu , Ying Tang , … Show All … , Feng Li , Qi Ren , song zhang 0000-0002-9478-3784 , Yiling Huang , Ying Li , Yawen Yin , Yanlan Zhong , Yongli Chen , Zichan Mai , Jiamin Lu , Yanqing Zhang , and Ping Zeng 0009-0001-1588-1483 [email protected] Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.176716996.62328822/v1 104 views 56 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective: Explore the potential factors that could help to distinguish Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in pediatric patients. Methods: This single-center study enrolled 60 children (aged <18 years) who were diagnosed with SJS and TEN between 2017 and 2024, with an average follow-up duration of 381.3 ± 486.5 days. Diagnosis and classification of SJS and TEN were based on clinical manifestations and Bastuji-Garin criteria[1](#ref-0001). SJS (< 10% of body surface area) and TEN (≥10% . Collected clinical data and laboratory experiments from patients and measured the expression of cytokines in the plasma, and the percentages and absolute counts of lymphocytes in peripheral blood. Then, statistical analyses were conducted to identify the risk factors of SJS compared to TEN. Results: A total of patients were divided into two groups: 21 patients with SJS, 39 patients with TEN. The median onset age was 6.5 years (range 0.5 to 15 years). Among these patients, 40 (67%) were male. All clinical characteristics and laboratory indicators with statistically significant differences were included as candidates in the multivariable model. Using backward stepwise logistic regression, it was determined that Complement 4 > 0.3 g/L and RBC > 3.89 × 10^12/L were significant positive predictors of SJS. Meanwhile, tongue involvement (SJS, 67% vs. TEN, 97%) and the presence of mucosal blisters (SJS, 62% vs. TEN, 95%) were significant negative predictors of SJS. Conclusion: Complement 4, RBC, involvement of the tongue, and mucosal blisters may be potential indicators for distinguishing SJS from TEN. Supplementary Material File (sjs -12-20.doc) Download 434.50 KB Information & Authors Information Version history V1 Version 1 31 December 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Xianfei Gao Guangzhou Women and Children's Medical Center View all articles by this author Caihong Xu Guangzhou Women and Children's Medical Center View all articles by this author Xi Lu The Sixth Affiliated Hospital of South China University of Technology View all articles by this author Danping Huang Guangzhou Women and Children's Medical Center View all articles by this author Mingqi Zhao Guangzhou Women and Children's Medical Center View all articles by this author Yifan Liu Guangzhou Women and Children's Medical Center View all articles by this author Ying Tang Guangzhou Women and Children's Medical Center View all articles by this author Feng Li Guangzhou Women and Children's Medical Center View all articles by this author Qi Ren Guangzhou Women and Children's Medical Center View all articles by this author song zhang 0000-0002-9478-3784 Guangzhou Women and Children's Medical Center View all articles by this author Yiling Huang Guangzhou Women and Children's Medical Center View all articles by this author Ying Li Guangzhou Women and Children's Medical Center View all articles by this author Yawen Yin Guangzhou Women and Children's Medical Center View all articles by this author Yanlan Zhong Guangzhou Women and Children's Medical Center View all articles by this author Yongli Chen Guangzhou Women and Children's Medical Center View all articles by this author Zichan Mai Guangzhou Women and Children's Medical Center View all articles by this author Jiamin Lu Guangzhou Women and Children's Medical Center View all articles by this author Yanqing Zhang Guangzhou Women and Children's Medical Center View all articles by this author Ping Zeng 0009-0001-1588-1483 [email protected] Guangzhou Women and Children's Medical Center View all articles by this author Metrics & Citations Metrics Article Usage 104 views 56 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Xianfei Gao, Caihong Xu, Xi Lu, et al. The discriminators of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis in children. Authorea . 31 December 2025. DOI: https://doi.org/10.22541/au.176716996.62328822/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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