Development of a Novel Proton Therapy Technique Using Resonant Nuclear Reactions: integrated proton-dynamic therapy, iPDT

Development of a Novel Proton Therapy Technique Using Resonant Nuclear Reactions: integrated proton-dynamic therapy, iPDT | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Development of a Novel Proton Therapy Technique Using Resonant Nuclear Reactions: integrated proton-dynamic therapy, iPDT Atsushi Taninaka, Hiromi Kurokawa, Yukito Kobayashi, Satoshi Ishii, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8084803/v1 This work is licensed under a CC BY 4.0 License Status: Under Revision Version 1 posted 10 You are reading this latest preprint version Abstract In a super-aged society, many patients take antithrombotic drugs for atherosclerotic diseases. Even such patients are not infrequently diagnosed with cancer, making the development of minimally invasive cancer treatments highly desirable. Radiation therapy is a non-bleeding treatment. However, it causes damage indiscriminately. Chemotherapy is also often unsuitable for the very elderly due to its secondary adverse events. This report proposes a world-first treatment method, which utilizes carbon beams and alpha particles generated by the resonance nuclear reaction between 15 N, specifically accumulated in cancer cells, and proton beams. The authors named it as an integrated proton-dynamic therapy, iPDT. This induces ionization effects 50 times greater than proton beams alone locally within the cancer tissue, causing its destruction while causing almost no damage to normal tissue. 15 N-aminolevulinic acid (ALA) was used for a cancer specific 15 N delivery. Three hours after the ALA treatment, the cells were irradiated with proton beam. After irradiation, morphological changes in cells were observed using time-lapse imaging. Furthermore, DNA damage induced by proton beam irradiation was evaluated by immunofluorescence staining for γH2AX. These studies revealed that 15 N delivery via aminolevulinic acid induces ( 15 N, αγ, 1H), 12 C nuclear resonance reactions, significantly increasing cell damage compared to proton irradiation alone. Biological sciences/Cancer Health sciences/Oncology ¹⁵N-labeled 5-aminolevulinic acid (¹⁵N 5-ALA) Atherosclerotic diseases Novel proton therapy technique iPDT Resonant nuclear reactions Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Revision Version 1 posted Editorial decision: Revision requested 21 Jan, 2026 Reviews received at journal 26 Dec, 2025 Reviews received at journal 11 Dec, 2025 Reviewers agreed at journal 05 Dec, 2025 Reviewers agreed at journal 04 Dec, 2025 Reviewers invited by journal 04 Dec, 2025 Editor assigned by journal 04 Dec, 2025 Editor invited by journal 04 Dec, 2025 Submission checks completed at journal 26 Nov, 2025 First submitted to journal 26 Nov, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8084803","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":555986593,"identity":"31438f80-1467-4b54-86a2-300c244dfb5d","order_by":0,"name":"Atsushi Taninaka","email":"","orcid":"","institution":"University of Tsukuba","correspondingAuthor":false,"prefix":"","firstName":"Atsushi","middleName":"","lastName":"Taninaka","suffix":""},{"id":555986594,"identity":"644a1ba5-9ca1-4026-8252-8276d95452c6","order_by":1,"name":"Hiromi Kurokawa","email":"","orcid":"","institution":"University of 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