Experimental Research on Shujie Yiweian Capsule Against Endometriosis in Rabbits

Objective To explore the therapeutic effect of shujie yiweian capsule on endometriosis. Methods The rabbit model of endometriosis was established by transplantation. The mode rabbits were i.g. shujie yiweian capsule 1.9,3.8,7.6 g·kg-1 for 4 weeks as low,middle and high dose. The appearance and growth of endometrium were observed and detected by histomorphological analysis; contents of estradiol(E2),gestagen (P),6-k-PG,TXB2 were measured by radioimmuno assay. Results It was showed that the quantity of liquid in ectopic endometrial tissue was decreased and the growth was inhibited. The ectopic endomembrane was shrunk,epithelium was thinner,no glandular organ was formed,the mesenchymal cells were small and sparse after the treatment of different doses of shujie yiweian capsules. The serum levels of E2、P、6-k-PG and TXB2 were decreased in the high and middle doses of shujie yiweian capsules treated rabbits. Conclusion Shujie yiweian capsule can holdback the growth of ectopic endometrium by decreasing hormone levels.