Magnetic Resonance Imaging-Guided Single-Fraction Preoperative Radiotherapy for Early Stage Breast Cancer (The RICE Trial): Feasibility Study

Magnetic Resonance Imaging-Guided Single-Fraction Preoperative Radiotherapy for Early Stage Breast Cancer (The RICE Trial): Feasibility Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Magnetic Resonance Imaging-Guided Single-Fraction Preoperative Radiotherapy for Early Stage Breast Cancer (The RICE Trial): Feasibility Study Ayyaz Qadir, Nabita Singh, Jenna Dean, Kerryn Brown, Mark Tacey, and 16 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4404818/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 07 Nov, 2024 Read the published version in Pilot and Feasibility Studies → Version 2 posted 3 You are reading this latest preprint version Show more versions Abstract Background: Over the past decade, the adoption of screening programs, digital mammography, and Magnetic Resonance Imaging (MRI) has increased early-stage breast cancer diagnosis rates. Mortality rates have decreased due to early detection, improved treatments, including personalized therapies. Accelerated partial breast irradiation (APBI) is emerging as a convenient and effective treatment for some patients, with studies exploring its preoperative use. Preoperative APBI, especially with MRI guidance, offers improved tumor targeting and reduced side effects. The RICE trial aims to assess the feasibility and efficacy of MRI-guided single-dose radiotherapy for early-stage breast cancer. Methods: The RICE study is a prospective, single-arm study evaluating single fraction pre-operative, accelerated partial breast irradiation treatment in patients with early-stage breast cancer using a Magnetic Resonance Imaging Linear Accelerator (MR Linac). Eligible patients enrolled in this study will have a core biopsy to confirm estrogen receptor positive, Her2 negative subtype. Radiotherapy planning will use a planning computed tomography co-registered with a magnetic resonance imaging (MRI) with the patient in either the supine or prone position. For the diagnostic workup, [18] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography ([18]FDG PET/CT) and [18] Fluoroestradiol Positron Emission Tomography/Computed Tomography ([18]FES PET/CT) will be performed prior to treatment. Thirty patients will receive a single ablative RT dose of 21 Gy to the tumor. Pre- and post-treatment MRI scans will be acquired at baseline and 5 weeks post radiotherapy respectively. Breast-conserving surgery will be scheduled for 6 weeks after APBI treatment using the MR- Linac. The primary study endpoint is the successful administration of a single fraction of preoperative breast radiotherapy under the guidance of an MR-linac. Secondary endpoints include evaluating the utility of MRI, [18F] FDG PET/CT and [18F] FES PET/CT as a non-invasive method for assessing treatment response in patients undergoing single fraction preoperative accelerated partial breast irradiation. Conclusion: The RICE trial represents a significant step in breast cancer treatment, offering insights that could lead to treatment protocols with minimized radiotherapy and enhanced patient outcomes. Trial Registration: This trial is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR). Registered 31st of May 2021. Registration number: ACTRN12621000659808 https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12621000659808 Full Text Cite Share Download PDF Status: Published Journal Publication published 07 Nov, 2024 Read the published version in Pilot and Feasibility Studies → Version 2 posted Editorial decision: Accept 16 Oct, 2024 Editor assigned by journal 31 Jul, 2024 First submitted to journal 26 Jul, 2024 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4404818","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[{"code":1,"date":"2024-06-11 20:29:07","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"pilot-and-feasibility-studies","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pafs","sideBox":"Learn more about [Pilot and Feasibility Studies](http://pilotfeasibilitystudies.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/PAFS/default.aspx","title":"Pilot and Feasibility 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