CYP1A1 genetic polymorphisms and uterine leiomyoma risk: a meta-analysis.

Fen Wang, Jiying Chen, Lin Wang, Yulan Ma, Mayinuer Niyazi
In: International journal of clinical and experimental medicine · 2015 · vol. 8(3) , pp. 3590–4 · PMID:26064254 · W2340408005
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This meta-analysis of nine studies found that the CYP1A1 Ile462Val genetic polymorphism is significantly associated with uterine leiomyoma risk in both Asian and Caucasian populations.

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Abstract

BACKGROUND: Some studies assessed the association between CYP1A1 MspI and Ile462Val polymorphisms and uterine leiomyoma (UL) risk. However, the results were controversial. We did this meta-analysis to determine the association between CYP1A1 MspI and Ile462Val polymorphisms and UL risk. MATERIALS AND METHODS: We searched databases containing PubMed, Springer Link, EMBASE, Chinese National Knowledge Infrastructure (CNKI) up to 11 October 2014. Pooled ORs and 95% CIs were used to assess the strength of the associations. RESULTS: In total, 9 case-control studies with 2157 UL cases and 2197 healthy controls were included in this meta-analysis. CYP1A1 Ile462Val polymorphism was significantly associated with UL risk (OR = 2.29, 95% CI 1.75-2.99, P < 0.00001). In the subgroup analysis by race, significantly increased risks were found in the Asians (OR = 2.76, 95% CI 1.86-4.09, P < 0.00001) and Caucasians (OR = 1.87, 95% CI 1.30-2.68, P = 0.0007). However, MspI polymorphism was not significantly associated with UL risk (OR = 1.15, 95% CI 0.90-1.47, P = 0.27). In the subgroup analysis by race, no significant association was found in the Asians (OR = 1.15, 95% CI 0.86-1.54, P = 0.35). CONCLUSION: In summary, the results of the meta-analysis suggested that CYP1A1 Ile462Val polymorphism was significantly associated with UL risk.

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