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This study compared endometriomas to non-endometriotic cysts and normal ovarian tissue, finding decreased neuroendocrine marker expression in endometriomas and increased p53 staining.
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by claude@2026-06, 2026-06-13
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This study compared immunohistochemical features, focusing on neuroendocrine cells and related marker densities, among 20 patients with endometrioma and 30 controls consisting of normal ovarian tissue and serous or mucinous benign ovarian cystadenomas, using H-score based staining density. Endometrioma samples showed higher p53 staining than non-endometriotic cysts and normal ovarian tissue, while neuroendocrine markers PGP9.5, NSE, and SYN were higher in normal ovarian tissue than in endometrioma and non-endometriotic cysts, indicating decreased neuroendocrine marker expression during endometrioma transformation. PAS and VanGieson staining were more intense in mucinous cystadenomas than endometriomas, and macrophage deposition was higher in endometrioma and normal tissue compared with serous and mucinous cystadenomas. A key limitation is the relatively small sample size and cross-sectional design using mainly observational tissue comparisons. This paper is centrally about endometriosis — it specifically analyzes immunohistochemical characteristics of endometriomas versus non-endometriotic benign ovarian cysts, including neuroendocrine marker expression.
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Abstract
OBJECTIVE: The aim of the study was to investigate the existence of neuroendocrine cells and to compare the density of those in normal ovarian tissue, endometriotic and non-endometriotic benign ovarian cysts.
PATIENTS AND METHODS: Twenty patients with the diagnosis of endometrioma and 30 control subjects consisting of ovarian serous cystadenoma (n=10), ovarian mucinous cystadenoma (n=10) and normal ovarian tissue (n=10) were included. The tissues were prepared and assessed according to staining density by using the H-score method.
RESULTS: Tissues with mucinous cystadenoma were significantly more stained with PAS and VanGieson, when compared to women with endometrioma. Macrophage deposition was higher in cyst samples with endometrioma and in normal ovarian tissue when compared to serous cystadenoma and mucinous cystadenoma. Normal ovarian tissue was significantly more stained with PGP9.5, NSE and SYN when compared to endometrioma and non-endometriotic benign ovarian cyst. PGP9.5 staining was higher in normal ovarian tissue when compared with endometriotic lesions (p<.001). Endometrioma samples were significantly more stained with p53 when compared to non-endometriotic cysts and normal ovarian tissue. c-Kit staining was mild and not statistically significant among all groups.
CONCLUSIONS: During endometrioma transformation, expression intensity of neuroendocrine markers decreases compared to normal ovarian tissue and other benign ovarian cysts.
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Objective
The aim of the study was to investigate the existence of neuroendocrine cells and to compare the density of those in normal ovarian tissue, endometriotic and non-endometriotic benign ovarian cysts.
PATIENTS AND METHODS: Twenty patients with the diagnosis of endometrioma and 30 control subjects consisting of ovarian serous cystadenoma (n=10), ovarian mucinous cystadenoma (n=10) and normal ovarian tissue (n=10) were included. The tissues were prepared and assessed according to staining density by using the H-score method.
Results
Tissues with mucinous cystadenoma were significantly more stained with PAS and VanGieson, when compared to women with endometrioma. Macrophage deposition was higher in cyst samples with endometrioma and in normal ovarian tissue when compared to serous cystadenoma and mucinous cystadenoma. Normal ovarian tissue was significantly more stained with PGP9.5, NSE and SYN when compared to endometrioma and non-endometriotic benign ovarian cyst. PGP9.5 staining was higher in normal ovarian tissue when compared with endometriotic lesions (p<.001). Endometrioma samples were significantly more stained with p53 when compared to non-endometriotic cysts and normal ovarian tissue. c-Kit staining was mild and not statistically significant among all groups.
Conclusions
During endometrioma transformation, expression intensity of neuroendocrine markers decreases compared to normal ovarian tissue and other benign ovarian cysts.
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To cite this article
F.T. Cagiran, Z. Kali, P. Kirici, O. Celik
Comparison of immunohistochemical characteristics of endometriomas with non-endometriotic benign ovarian cysts
Eur Rev Med Pharmacol Sci
Year: 2022
Vol. 26 - N. 20
Pages: 7594-7599
DOI: 10.26355/eurrev_202210_30034
Publication History
Published online: 28 Oct 2022
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