Correlation Study Between Occupational Hazardous Factor Exposome and Bone Mineral Density Abnormality in Steelworkers

Correlation Study Between Occupational Hazardous Factor Exposome and Bone Mineral Density Abnormality in Steelworkers | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Correlation Study Between Occupational Hazardous Factor Exposome and Bone Mineral Density Abnormality in Steelworkers Haoruo Zhang, Ziwei Zheng, Nan Wang, Zheng Li, Shangmingzhu Zhang, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4562092/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 16 Apr, 2025 Read the published version in BMC Public Health → Version 1 posted 4 You are reading this latest preprint version Abstract Objectives To investigate associations among occupational hazardous factor exposure groups and bone mineral density (BMD) abnormalities in steelworkers, by analyzing correlation between various occupational hazardous factors (night-shift work, high temperature, dust and noise) and BMD abnormalities. Methods A total of 6816 participants were recruited for this study. Night-shift work, high temperature, dust and noise was taken as occupational hazardous factors, analyzed as a unique factor by each and as an exposome together. Health risk factor score and partial regression coefficient were used to establish a single risk score exposure group model and a hybrid risk score exposure group model. Results Detection rate of abnormal BMD in steelworkers was 27.6%, of which 28.0% in males and 23.3% in females. Single risk score model showed, compared with the control group (score <0.440), steelworkers with scores of 0.440~, 0.778~, and ≥1.078 had a abnormal BMD risk of 1.252 (1.034~1.516) folds, 1.534 (1.253~1.878) times, and 2.234 (1.808~2.759) times. Combined risk score model showed that, compared with the reference group(score<0.366), steelworkers with a score in 0.366~, 0.621~, and ≥0.872 were 1.167 (0.969~1.405) times, 1.470 (1.205~1.794) times, and 2.136 (1.738~2.626) times, respectively. Conclusions 1 Night-shift work, high temperature, dust, and noise may contribute to BMD abnormality in steelworkers. 2 The higher the corresponding risk score of the occupational hazardous factor exposome, the higher the risk of BMD abnormality in steelworkers. When workers are exposed to multiple occupational hazards at the same time, constructing an exposome could reveal the relationship between occupational hazardous factors and BMD abnormality in steelworkers more accurately. Full Text Additional Declarations No competing interests reported. Supplementary Files attachedtable1and2.docx Cite Share Download PDF Status: Published Journal Publication published 16 Apr, 2025 Read the published version in BMC Public Health → Version 1 posted Editorial decision: Revision requested 12 Jun, 2024 Editor assigned by journal 11 Jun, 2024 Submission checks completed at journal 11 Jun, 2024 First submitted to journal 11 Jun, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4562092","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":313394171,"identity":"0788749d-b8f2-4c8f-bf0e-adc03e9bfb26","order_by":0,"name":"Haoruo Zhang","email":"","orcid":"","institution":"North China University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Haoruo","middleName":"","lastName":"Zhang","suffix":""},{"id":313394172,"identity":"e7f888ea-0540-49e0-9197-bd0619e7ff16","order_by":1,"name":"Ziwei Zheng","email":"","orcid":"","institution":"North China University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Ziwei","middleName":"","lastName":"Zheng","suffix":""},{"id":313394173,"identity":"7d71dacd-9782-4e6c-9a07-a9376b893a76","order_by":2,"name":"Nan Wang","email":"","orcid":"","institution":"North China University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Nan","middleName":"","lastName":"Wang","suffix":""},{"id":313394174,"identity":"0766f4d4-bbf9-4617-b5ed-84b0864ed334","order_by":3,"name":"Zheng Li","email":"","orcid":"","institution":"North China University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Zheng","middleName":"","lastName":"Li","suffix":""},{"id":313394175,"identity":"550fb472-4249-46bd-a785-ebb0441c75cf","order_by":4,"name":"Shangmingzhu Zhang","email":"","orcid":"","institution":"North China University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Shangmingzhu","middleName":"","lastName":"Zhang","suffix":""},{"id":313394176,"identity":"398be901-9a86-4c9c-bd9a-27e3eb82d3f6","order_by":5,"name":"Yu Su","email":"","orcid":"","institution":"North China University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Yu","middleName":"","lastName":"Su","suffix":""},{"id":313394177,"identity":"68a78989-372e-493b-9846-1503c1672f09","order_by":6,"name":"Jianhui Wu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABAklEQVRIiWNgGAWjYHCChAMMDAcY2OTPP//wASokQZwWCR42xhlALg8RWkAAqAuohZmHGC0GNxIeHvi5405in3Tvsce2O+zs7RmYD97mYbDLw6Ml4WDvmWeJbTLn0o1zzyQn9jCwJVvzMCQX49JiBtRygLftcGIbQ4KBdG7bgQQeBh4zaR6GA4kNeLQc/AvTYtl2wJ6Hgf8bQS2HwbZI5JhJM7YdYOxh4GHDq8X+zIOEw7Jth43beI4lG/a2Af1ymM3Yco5BMk4tku05yR/fth2Wnd/efPDBzzY7e/b25oc33lTY4dQCjIcENAFmEGGAUz0QsB/AJzsKRsEoGAWjgIEBAGv+XJPF3N4tAAAAAElFTkSuQmCC","orcid":"","institution":"North China University of Science and Technology","correspondingAuthor":true,"prefix":"","firstName":"Jianhui","middleName":"","lastName":"Wu","suffix":""}],"badges":[],"createdAt":"2024-06-11 07:31:31","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4562092/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4562092/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12889-025-22713-4","type":"published","date":"2025-04-16T15:57:38+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":81050975,"identity":"8f2058a5-ede4-43e7-9cde-1bfffeb6b2df","added_by":"auto","created_at":"2025-04-21 16:09:13","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":342142,"visible":true,"origin":"","legend":"","description":"","filename":"CorrelationStudyBetweenOccupationalHazardousFactorExposomeandBoneMineralDensityAbnormalityinSteelworkers.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4562092/v1_covered_e0b2b4a7-4221-412e-912a-d4bc1e4601b0.pdf"},{"id":59186248,"identity":"5ab5799e-d92c-4cec-99e8-3542fd0adbe0","added_by":"auto","created_at":"2024-06-27 12:06:06","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":18462,"visible":true,"origin":"","legend":"","description":"","filename":"attachedtable1and2.docx","url":"https://assets-eu.researchsquare.com/files/rs-4562092/v1/f15c6c16a90f78c832cf42cc.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Correlation Study Between Occupational Hazardous Factor Exposome and Bone Mineral Density Abnormality in Steelworkers","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-public-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pubh","sideBox":"Learn more about [BMC Public Health](http://bmcpublichealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/pubh/default.aspx","title":"BMC Public Health","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4562092/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4562092/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjectives\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo investigate associations among occupational hazardous factor exposure groups and bone mineral density (BMD) abnormalities in steelworkers, by analyzing correlation between various occupational hazardous factors (night-shift work, high temperature, dust and noise) and BMD abnormalities.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA\u003cstrong\u003e \u003c/strong\u003etotal of\u003cstrong\u003e \u003c/strong\u003e6816 participants were recruited for this study. Night-shift work, high temperature, dust and noise was taken as occupational hazardous factors, analyzed as a unique factor by each and as an exposome together. Health risk factor score and partial regression coefficient were used to establish a single risk score exposure group model and a hybrid risk score exposure group model.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDetection rate of abnormal BMD in steelworkers was 27.6%, of which 28.0% in males and 23.3% in females. Single risk score model showed, compared with the control group (score \u0026lt;0.440), steelworkers with scores of 0.440~, 0.778~, and ≥1.078 had a abnormal BMD risk of 1.252 (1.034~1.516) folds, 1.534 (1.253~1.878) times, and 2.234 (1.808~2.759) times. Combined risk score model showed that, compared with the reference group(score\u0026lt;0.366), steelworkers with a score in 0.366~, 0.621~, and ≥0.872 were 1.167 (0.969~1.405) times, 1.470 (1.205~1.794) times, and 2.136 (1.738~2.626) times, respectively.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e1 Night-shift work, high temperature, dust, and noise may contribute to BMD abnormality in steelworkers. 2 The higher the corresponding risk score of the occupational hazardous factor exposome, the higher the risk of BMD abnormality in steelworkers. When workers are exposed to multiple occupational hazards at the same time, constructing an exposome could reveal the relationship between occupational hazardous factors and BMD abnormality in steelworkers more accurately.\u003c/p\u003e","manuscriptTitle":"Correlation Study Between Occupational Hazardous Factor Exposome and Bone Mineral Density Abnormality in Steelworkers","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-06-27 12:06:01","doi":"10.21203/rs.3.rs-4562092/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-06-12T04:35:53+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-06-12T03:41:58+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-06-12T03:08:39+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Public Health","date":"2024-06-11T07:30:08+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-public-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pubh","sideBox":"Learn more about [BMC Public Health](http://bmcpublichealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/pubh/default.aspx","title":"BMC Public Health","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"8362f5e9-001b-41d1-84b0-a945fd7a2581","owner":[],"postedDate":"June 27th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2025-04-21T16:03:52+00:00","versionOfRecord":{"articleIdentity":"rs-4562092","link":"https://doi.org/10.1186/s12889-025-22713-4","journal":{"identity":"bmc-public-health","isVorOnly":false,"title":"BMC Public Health"},"publishedOn":"2025-04-16 15:57:38","publishedOnDateReadable":"April 16th, 2025"},"versionCreatedAt":"2024-06-27 12:06:01","video":"","vorDoi":"10.1186/s12889-025-22713-4","vorDoiUrl":"https://doi.org/10.1186/s12889-025-22713-4","workflowStages":[]},"version":"v1","identity":"rs-4562092","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4562092","identity":"rs-4562092","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}