COMPARISON OF LOW-FREQUENCY PIEZOELECTRIC THROMBOELASTOGRAPHY DATA IN PATIENTS WITH GENITAL ENDOMETRIOSIS USING THE NPO STRATEGY FOR PREOPERATIVE PREPARATION WITH THE BASELINE STATE OF THE HEMOSTASIS SYSTEM

According to WHO, endometriosis affects about 190 million women of reproductive age worldwide. Despite the prevalence of the pathology, its proven effect on the hemostasis system, data on this effect are heterogeneous. The paper investigates the problem of the influence of preoperative management of patients with genital endometriosis, according to the nil per os (NPO) strategy and changes in the hemostasis system against the background of such tactics; the initial state of the hemostasis system of such patients and its response to the test with local double hypoxia of the upper limb are compared. In the study group of 32 patients aged 20–35 years who were diagnosed with genital endometriosis, using low-frequency piezoelectric thromboelastography (LPTEG), the hemostasis response to pathology was assessed: baseline data, after a test with double local hypoxia without the NPO strategy and with its use. The obtained data indicate the presence of moderate statistically significant disorders in the direction of hypocoagulation during a stress test without using the NPO strategy , and moderate statistically significant disorders in the direction of hypercoagulation during a stress test in the case of using the NPO strategy. The presented data confirm the hypothesis of the possibility of predicting disorders in the hemostasis system of the studied patients in relation to the management strategy and the influence of factors that can be modified in the preoperative period; however, the overall impact of these changes on the course of the perioperative period, the spectrum of external factors with the possibility of a similar effect, the need to use therapeutic strategies for the prevention of thrombosis and bleeding – as well as the monitoring regimen for these changes – remain open to research and discussion.