State of coagulating and anticoagulating systems in women who used oral contraceptives

It is known that a prolonged use of combinations of nortestosterone and estrogens may cause some side effects among which modifications in the blood coagulation and anticoagulation systems. A study was done on 100 women divided in 2 groups. The 1st group consisted of 70 women who were taking estrogeno-gestagen combinations: 37 for dysfunction of the ovaries 16 for endometriosis 1 for dysmenorrhea 1 for climacteric syndrome and 15 for contraceptive purposes. 22 women had taken the oral contraceptives for 3 months 16 for 4-6 months 13 for 7-9 months 4 for 1 year and 15 for over 1 year. The 2nd group consisted of 30 women among which 8 had ovarian dysfunctions 8 endometriosis 4 climacteric syndrome 2 dysmenorrhea; 8 were healthy. Blood analyses were performed during the treatment in women of the 1st group and before the beginning of the treatment for the women from the 2nd group. Thromboelastograms and coagulograms revealed an increased blood coagulating activity in the women from the 1st group who had been taking contraceptive agents. (Summary in ENG).