Autoantibodies research in patients with endometriosis: A cross-sectional study

Cesar Augusto Capellari, Danilo Rahal, Carlos Bezerra Sobrinho, Laura Vilas Boas, Thelma Skare, Renato Nisihara
In: Research Square · 2024 · doi:10.21203/rs.3.rs-3872997/v1 · W4391096290
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Abstract

Abstract Background Endometriosis is a common inflammatory disease with an unknown etiology; dysregulation of the immune system appears to play a role in this context. Objective To study the presence of autoantibodies in patients with endometriosis. Methods Two hundred and two females (111 with endometriosis and 91 controls) were studied for the presence of Antinuclear Antibodies (ANA), Extractable Nuclear Antigens (ENA) profile; anti-dsDNA, anticardiolipin (aCl) IgG and IgM and anti endomysial Antibodies (EmA-IgA). Clinical data, obstetric and gynecological history were collected. Results ANA was positive in 26/111 (23.4%) females with endometriosis vs. 5/91 (5.4%) in the control sample (p = 0.0004; OR = 5.26; 95% CI = 1.92–14.30). None of the samples were positive for aCl IgG or IgM; ds-DNA, ENA profile or EMA. No associations between ANA positivity and clinical, obstetrical and gynecological data were found. Conclusion Patients with endometriosis showed high positivity for ANA, but not to the more specific autoantibodies.

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endometriosis

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