Clinically Significant Danazol-Carbamazepine Interaction

Janusz J. Zielinski, Edward M. Lichten, Dan Haidukewych
In: Therapeutic Drug Monitoring · 1987 · vol. 9(1) , pp. 24–27 · doi:10.1097/00007691-198703000-00005 · PMID:3107168 · W1995380247
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Danazol therapy significantly increased carbamazepine serum levels nearly twofold in six patients, indicating a clinically important interaction that necessitates monitoring carbamazepine levels when administered concurrently.

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Abstract

In six patients with epilepsy and fibrocystic breast disease the concentration in serum of antiepileptic drugs was obtained before, during, and after danazol therapy. Carbamazepine serum levels increased almost twofold in the presence of danazol. Thus, interaction between carbamazepine and danazol producing acute carbamazepine toxicity is clinically significant. If these drugs are administered concurrently, an awareness of the potential for this drug-drug interaction along with monitoring of carbamazepine levels is required for optimal patient care.
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Article: PDF Only Clinically Significant Danazol-Carbamazepine Interaction - Janusz J. Zielinski - Edward M. Lichten - Dan Haidukewych Therapeutic Drug Monitoring 9(1):p 24-27, March 1987. Summary In six patients with epilepsy and fibrocystic breast disease the concentration in serum of antiepileptic drugs was obtained before, during, and after danazol therapy. Carbamazepine serum levels increased almost twofold in the presence of danazol. Thus, interaction between carbamazepine and danazol producing acute carbamazepine toxicity is clinically significant. If these drugs are administered concurrently, an awareness of the potential for this drug-drug interaction along with monitoring of carbamazepine levels is required for optimal patient care. Copyright © Lippincott-Raven Publishers.

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