What are the most significant biomarkers associated with infertility in patients with endometriosis and pelvic pain?

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This review identifies potential biomarkers for endometriosis-associated infertility, including CA125, NO, metabolites, and genetic indicators, while noting that no single marker has achieved clinical validation.

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This review examines the current evidence regarding biomarkers associated with infertility in patients presenting with endometriosis and pelvic pain. It highlights a wide array of potential indicators, including CA125, nitric oxide, specific metabolites, genetic and epigenetic markers, as well as hormonal dysregulation indicators. Despite the identification of these numerous candidates, the authors note that no single marker has yet achieved clinical validation for diagnostic use. This paper is centrally about endometriosis — specifically focusing on the search for reliable biomarkers to diagnose infertility associated with the condition.

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Abstract

Current evidence suggests a wide array of potential biomarkers for endometriosis-associated infertility, but no single marker has yet achieved clinical validation. Highlighted markers include CA125, NO, specific metabolites, genetic/epigenetic markers, and hormonal dysregulation indicators.
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Published November 17, 2025 | Version v1 Other Open What are the most significant biomarkers associated with infertility in patients with endometriosis and pelvic pain? Description Current evidence suggests a wide array of potential biomarkers for endometriosis-associated infertility, but no single marker has yet achieved clinical validation. Highlighted markers include CA125, NO, specific metabolites, genetic/epigenetic markers, and hormonal dysregulation indicators. Files 1234d815-3cc4-461e-8084-f36409d1b81a.pdf Files (18.6 kB) | Name | Size | Download all | |---|---|---| | md5:e64b8b1bb95ec614837aaa379d3a65aa | 18.6 kB | Preview Download |

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endometriosisinfertility

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last seen: 2026-06-10T17:14:06.276822+00:00
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