Comparison of CRISPLD2 expression in the endometrium between eutopic and ectopic endometriosis lesions.

Jung-Yoon Yoo (462528), Heesung Shin (582242), Tae Hoon Kim (128536), Won-Seok Choi (582243), Susan D. Ferguson (462531), Asgerally T. Fazleabas (462533), Steven L. Young (513583), Bruce A. Lessey (582244), Un-Hwan Ha (35209), Jae-Wook Jeong (143654)
2015 · doi:10.1371/journal.pone.0100481.g003 · W6960464330
other OA: green CC0
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This study investigated the expression levels of CRISPLD2, a target of the progesterone receptor, within endometrial tissues. Researchers compared immunohistochemical staining intensity in both eutopic endometrium and ectopic lesions derived from women with endometriosis. The analysis revealed that CRISPLD2 expression was significantly decreased in the ectopic endometriotic lesions relative to the eutopic endometrium, particularly in epithelial and stromal cells. This paper is centrally about endometriosis — specifically examining molecular differences between eutopic and ectopic disease sites.

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Abstract

(A) Representative immunohistochemistry of CRISPLD2 in eutopic and ectopic endometrium with endometriosis. (B and C) CRISPLD2 was scored by measuring expression intensity of endometrial epithelial (B) and stromal (C) cells. The results represent the mean ± SEM. *** p<0.001; * p<0.05
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CRISPLD2 Is a Target of Progesterone Receptor and Its Expression Is Decreased in Women with Endometriosis Figure 3 Comparison of CRISPLD2 expression in the endometrium between eutopic and ectopic endometriosis lesions. (A) Representative immunohistochemistry of CRISPLD2 in eutopic and ectopic endometrium with endometriosis. (B and C) CRISPLD2 was scored by measuring expression intensity of endometrial epithelial (B) and stromal (C) cells. The results represent the mean ± SEM. *** p<0.001; * p<0.05

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endometriosis

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