Chemical structure of corticosteroids and its relationship with their acute induction of lordosis in the female rat

Carlos Kubli‐Garfias, C Kubli-Garfias
Hormones and behavior · 1990 · vol. 24(4) , pp. 443–449 · doi:10.1016/0018-506x(90)90033-t · PMID:2286360 · W2068500640
Lab / animal OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-14 ⓘ

This study investigated the relationship between the chemical structure of corticosteroids and their ability to acutely induce lordosis behavior in female rats.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The intravenous injection of several corticosteroids in the spayed estrogen-primed rat resulted, 5 min later, in a remarkable induction of lordosis response for deoxycorticosterone and 11-deoxycortisol. A lower but important effect was induced with corticosterone and 17 alpha-hydroxyprogesterone. A chemical structure-biological effect analysis showed that C-21 hydroxylation (e.g., deoxycorticosterone, 11-deoxycortisol, and corticosterone) induces the behavioral effect. However, C-11 or C-17 hydroxylation alone promotes the lordosis response to a lesser degree (corticosterone and 17 alpha-hydroxyprogesterone, respectively). However, the effect of these latter compounds is significant. From the results, it is concluded that deoxycorticosterone and 11-deoxycortisol along with other steroids such as 20 alpha-hydroxyprogesterone are suitable candidates for synergizing the well-known estrogen-progesterone induction of lordotic behavior.

My notes (saved in your browser only)

MeSH descriptors

Adrenal Cortex Hormones Sexual Behavior, Animal Adrenal Cortex Hormones Adrenal Cortex Hormones Animals Computer Graphics Female Models, Molecular Molecular Conformation Progesterone Progesterone Rats Rats, Inbred Strains Sexual Behavior, Animal Structure-Activity Relationship

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (17)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:10:37.302907+00:00
License: CC0 · commercial use OK