Clinical Study of Laparoscopic Operations Combined With Endocrinal Therapy on Endometriosis Associated With Infertility.

Objective To study the clinical value of laparoscopic operation combined with endocrinal therapy on endometriosis associated with infertility. Methods From January 2003 to January 2007, a total of 341 cases of endometriosis(EM) associated with infertility who were underwent laparoscopic operations were included in this study. After the laparoscopic operation, they were divided into 3 groups, without endocrinal therapy group (control group, n=134), treated with gestrinone group (group A, n=93), and treated with gonadotropin releasing hormone analogues (GnRHa) group (group B, n=114). Results In the cases of stage Ⅰ and Ⅱ, the pregnancy rate was 30.1% in control group and the average pregnant rate was 39.2% in group A and B. There had no significant difference among three groups (P>0.05). In the cases of stage Ⅲ and Ⅳ, the average pregnancy rates were 23.0% and 37.5% in control group and group B, C, respectively. There had no significant difference among three groups (P>0.05). The average pregnancy rate of group B (45.6%) was significant high than that of group A (28.3%) (P<0.05). Conclusion Laparoscopic operation can be used in the treatment of endometriosis associated with infertility. In the cases of stage Ⅲ and Ⅳ, laparoscopic operation combined with post-operative endocrinal therapy is of importance effects, and gonadotropin releasing hormone analogues is the best choice. Key words: endometriosis(EM); infertility; laparoscopy; gonadotropin releasing hormone analogues (GnRHa)