Progestin re-treatment in patients with recurrent endometrial adenocarcinoma after successful fertility-sparing management using progestin

Jeong-Yeol Park, Jeong‐Yeol Park, Sang‐Hun Lee, Sang-Hun Lee, Seok Ju Seong, Dae-Yeon Kim, Dae‐Yeon Kim, Tae‐Jin Kim, Tae-Jin Kim, Jae‐Weon Kim, Jae Weon Kim, Jong-Hyeok Kim, Yong-Man Kim, Yong‐Man Kim, Young‐Tak Kim, Young-Tak Kim, Duk‐Soo Bae, Duk-Soo Bae, Joo-Hyun Nam, Joo‐Hyun Nam
Gynecologic Oncology · 2012 · vol. 129(1) , pp. 7–11 · doi:10.1016/j.ygyno.2012.12.037 · PMID:23283299 · W2021542768
Other OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-11 ⓘ

This study investigated the efficacy and safety of re-administering progestin therapy in patients who experienced recurrent endometrial adenocarcinoma after initial successful fertility-sparing management with progestin.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To analyze the outcomes of second round of fertility-sparing management using progestin in patients with recurrent endometrial cancer after successful fertility-sparing management using progestin. METHODS: We reviewed 45 patients who had recurrence after achieving complete remission by fertility-sparing management using progestin for presumed stage IA, grade 1, endometrioid adenocarcinoma of the uterus. Of 45 patients, 33 tried progestin re-treatment at recurrence and were included in this study. RESULTS: Recurrent disease was atypical hyperplasia in 13 patients (39%) and grade 1 endometrioid adenocarcinoma in 20 patients (61%) which were confined to the endometrium. Thirty patients (91%) received medroxyprogesterone acetate (dose range, 80-500 mg/day) and three patients (9%) received megestrol acetate (dose range, 80-160 mg/day), with 29 patients receiving a dose of 500 mg/day of medroxyprogesterone acetate. The median duration of treatment was 6 months (range, 3-19 months). Five patients failed to respond to progestin re-treatment and underwent definitive surgical treatment including hysterectomy. Twenty eight patients (85%) showed complete response to progestin re-treatment. The median follow-up time after progestin re-treatment in 28 patients who achieved complete remission was 51 months (range, 24-160 months). During follow-up, five patients had second recurrence after median time interval of 14 months (range, 4-82 months). All patients who tried progestin re-treatment are alive without evidence of disease. CONCLUSION: Progestin re-treatment in patients with recurrent endometrial cancer was effective and safe. Therefore, this can be recommended for young women who still want to preserve fertility at recurrence after complete response to progestin.

My notes (saved in your browser only)

MeSH descriptors

Adenocarcinoma Endometrial Neoplasms Fertility Preservation Neoplasm Recurrence, Local Progestins Adenocarcinoma Adult Endometrial Neoplasms Endometrial Neoplasms Female Follow-Up Studies Humans Medroxyprogesterone Acetate Medroxyprogesterone Acetate Megestrol Acetate Megestrol Acetate Neoplasm Recurrence, Local Neoplasm Recurrence, Local Progestins Progestins

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (1)

References (23)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:11:19.299510+00:00
License: CC0 · commercial use OK