Oocyte and embryo cryopreservation before gonadotoxic treatments: Principles of safe ovarian stimulation, a systematic review.

ObjectiveReview the safety of fertility preservation through ovarian stimulation with oocyte or embryo cryopreservation, including cycle and medication options.Evidence reviewA systematic review of peer-reviewed sources revealed 2 applicable randomized control trials and 60 cohort studies as well as 20 additional expert opinions or reviews.ResultsThe capacity for future family building is important for the majority of reproductive age people, despite life-altering medical or oncologic diagnosis. Modern fertility preservation generates a high rate of oocyte yield while utilizing protocols that can be started at multiple points in the menstrual cycle and suppressing supra-physiologic levels of estrogen. Finally, more than one quarter of fertility preservation patients will return to later utilize fertility services.ConclusionFor most patients, fertility preservation can safely be pursued and completed within 2 weeks without affecting disease severity or long-term survival.