The expressions of matrix metalloproteinase-9, estrogen receptor, and progesterone receptor in thin endometrial tissue and their significance

Linhong Li, Gang Shi, Jinbing Pan, Caihong Wang, Min Zhao, Xiuping Zhang
In: Gynecological Endocrinology · 2022 · vol. 38(6) , pp. 516–522 · doi:10.1080/09513590.2022.2053957 · PMID:35426338 · W4223888822
article OA: bronze CC0 ⤵ 2 in-corpus citations
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This study found that refractory thin endometrium is associated with reduced endometrial glands and significantly lower ER and MMP-9 expressions compared to normal endometrium.

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Abstract

OBJECTIVE: This study aims to investigate the expressions of matrix metalloproteinase-9 (MMP-9), estrogen receptor (ER), and progesterone receptor (PR) in thin endometrium. METHODS: = 50, each). Patients in the thin endometrium group had an endometrial thickness of <7 mm, while patients in the normal endometrium group had an endometrial thickness of 7-10 mm. RESULTS: < .05). The receiver operator characteristic curve revealed that ER and MMP-9 had a high prediction accuracy in patients with refractory thin endometrium, while the number of endometrial glands was moderately predictive. CONCLUSION: Compared with other patients with thin endometrium, patients with refractory thin endometrium had a reduced the number of endometrial glands and significantly lower ER and MMP-9 expressions.

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