Активність природних кілерних клітин в еутопічному ендометрії при аденоміозі у жінок з різними імплантаційними характеристиками

The objective: of the study was a comparative study of the number and distribution of NK-cells in eutopic endometrium at adenomyosis in women with different implantation characteristics. Patients and methods. A comparative analysis of 32 endometrial samples from non-pregnant women of reproductive age with adenomyosis and a history of miscarriage, 30 non-pregnant women with adenomyosis who desired pregnancy ended in childbirth, and there were no episodes of spontaneous abortion, and 10 conditionally gynecologically healthy non-pregnant women without adenomyosis, who desired pregnancy ended in childbirth. It was investigated endometrium content of NK-cells using liquid murine monoclonal antibodies to the antigens CD16 + and CD56 + by immunohistochemistry. Results. It was found that infiltration of eutopic endometrial by NK-cells in women with adenomyosis exceeds that of conventionally healthy fertile persons. At adenomyosis the number of CD56+NK-cells in eutopic endometrium in women with implantation failure exceeds that in patients with implantation competence in 6.8 times (p<0,01), CD16+NK-cells – in 7.1 times (p<0,01). Conclusion. Determination of NK-cells in eutopic endometrium of women with adenomyosis can be used at the stage of the pre-gravid preparation for the forecast of implantation success and carry out the necessary immune correction. Key words: adenomyosis, eutopic endometrium, immunohistochemistry, natural killer cells, implantation failure.