[Molecular mechanism of Shaofu Zhuyu decoction in treating endometriosis dysmenorrhea based on GPER2/MAPK/STAT1 axis].

Cui YH, Yuhong Cui, Yu-Hong Cui, Jing Wu, Wu J, Cai W, Wei Cai, Du J, Juan Du, Jun-Min Cao, Cao JM, Junmin Cao, Xiu-Jia Ji, Ji XJ, Gong ZH, Zi-Han Gong
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · 2018 · vol. 43(16) , pp. 3362–3367 · doi:10.19540/j.cnki.cjcmm.20180408.004 · PMID:30200742 · W3024832964
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Shaofu Zhuyu decoction reduced inflammation and pain in endometriosis by inhibiting GPER2, MAPK, and STAT1 expression, thereby decreasing TNF-α, IL-6, and NK1 mRNA levels.

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Abstract

The aim of this paper is to study the molecular mechanism of Shaofu Zhuyu decoction in treating dysmenorrhea of endometriosis based on GPER2/MAPK/STAT1 axis. In this study, HE staining was used to observe the pathological changes of the rats in each group. The levels of TNF-α and IL-6 were detected by ELISA assay. The mRNA expressions of neurotransmitter receptor (NK1) and GPER were detected by qPCR. The protein contents of MAPK and STAT1 were detected by Western blot. According to the results, compared with the model group, Shaofu Zhuyu decoction could significantly improve the inflammation of the ectopic uterine cavity tissue, decrease the contents of TNF-α and IL-6 in the uterine cavity, the mRNA expressions of NK1 and GPER, and the protein expressions of MAPK and STAT1. In conclusion, Shaofu Zhuyu decoction could effectively inhibit the expressions of GPER2, MAPK and STAT1, decrease the levels of TNF-α, IL-6 and NK1 mRNA and relieve the inflammatory pain in patients with endometriosis.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Drugs, Chinese Herbal Dysmenorrhea Endometriosis Animals Drugs, Chinese Herbal Dysmenorrhea Endometriosis Female Inflammation Inflammation Interleukin-6 Interleukin-6 Rats Receptors, Estrogen Receptors, Estrogen Receptors, G-Protein-Coupled Receptors, G-Protein-Coupled Receptors, Neurokinin-1 Receptors, Neurokinin-1 STAT1 Transcription Factor

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