The Response of Tumor Microenvironment to Radiation Therapy: Analysis of the Disease-Free Survival of Patients with Endometrioid Adenocarcinoma of the Corpus Uteri

Objective: to identify the threshold values of FoxP3, CD56, PGRMC1, and Galectin-1 expression, to analyze the survival rate of female patients based on the obtained threshold values, to determine the statistical differences in groups depending on the presence/absence of radiotherapy. Mаteriаl аnd methods. The group with radiotherapy (LT+) included 42 female patients, the group without radiotherapy (LT-) included 38. The ROC-analysis was performed to determine the threshold values. The analysis of the survival rate was performed using the logrank test. The groups were compared using the tables 2×2 (Fisher's twosided test), as well as the odds ratio (OR) was calculated. The differences were considered statistically significant at p < 0.05. Results. The study of the Galectin-1 parenchymatous expression showed that statistically significant differences (p<0.0001) were revealed in the study of the relapsefree survival rate based on the obtained threshold value. Gamma ray therapy reduced the parenchymatous expression of Galectin-1 below the threshold value (OR = 0.490 95% CI 0.288-0.800). The analysis of the relapsefree survival rate on the basis of the obtained threshold value of the stromal expression of Galectin-1 revealed statistically significant differences (p = 0.0002). Gamma ray therapy reduced the stromal expression of Galectin-1 below the threshold value (OR = 0.289 95 % CI 0.112-0.742). Conclusion. At a low relapsefree survival rate, a statistically significant increase above the threshold values of the parenchymatous (p < 0.0001) and stromal (p = 0.0002) Galectin-1 expression was observed most frequently.