INHIBITION OF SMOOTH MUSCLE CELL MIGRATION BY (R)-AMLODIPINE

CHAHWALA Suresh Babubhai Pfizer Central Research, WINSLOW Derek Paul Pfizer Central Research
1997
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The R(+) isomer of amlodipine inhibits smooth muscle cell migration without calcium channel-blocking activity, offering potential therapeutic utility for treating endometriosis and other vascular conditions.

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Abstract

The R(+) isomer of amlodipine is a potent inhibitor of smooth muscle cell migration despite its lack of calcium channel-blocking activity. It is useful for treating atherosclerosis, re-stenosis after angioplasty and endometriosis.

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europepmc
last seen: 2026-07-16T06:15:11.481547+00:00