Hypodermal Decidualized Endometrioma With Aberrant Cytokeratin Expression. A Lesion Mimicking Malignancy

J. Fernando Val‐Bernal, José Fernando Val-Bernal, Daniel Val, Fernando Gómez-Aguado, Fernando Gómez, María Teresa Corcuera, María Francisca Garijo
The American Journal of dermatopathology · 2011 · vol. 33(5) , pp. e58–e62 · doi:10.1097/dad.0b013e3181f704f6 · PMID:21478729 · W2313912393
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case report describes a hypodermal decidualized endometrioma, a benign lesion that presented as a nodule mimicking malignancy due to aberrant cytokeratin expression.

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Abstract

Decidualized endometrioma is a pseudoneoplastic lesion that may appear as a solitary nodule in the hypodermis, simulate a malignant epithelioid tumor, and can represent a diagnostic challenge. A 36-year-old woman delivered a full-term baby by cesarean. At the immediate puerperium, she complained of a subcutaneous nodule measuring 2.5 cm, underneath a previous caesarean scar from the former full-term delivery 3 years earlier. Histologic features included a nodular growth pattern of large monomorphic epithelioid cells showing diffuse positivity for cytokeratin (AE1/AE3, 18), human placental lactogen, and CD10 and focal positivity for inhibin alpha. The main differential diagnoses include trophoblastic neoplasia and deciduoid mesothelioma. Good clinicopathological correlation is essential for the correct diagnosis. Immunohistochemical stains can be misleading. An important clue is the combination of large decidualized cells and lumens lined by flat or low cuboidal cells that are atrophic endometrial glands. This lesion has a benign behavior.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Keratins Skin Adult Diagnosis, Differential Endometriosis Endometriosis Female Gestational Trophoblastic Disease Gestational Trophoblastic Disease Humans Immunohistochemistry Keratins Mesothelioma Mesothelioma Pregnancy Skin

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (7)

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