Nonsteroidal anti-inflammatory drugs for management of pelvic pain in women

И. В. Кузнецова, L. V. Evsyukova
In: Medical Council · 2019 · pp. 27–33 · doi:10.21518/2079-701x-2019-7-27-32 · W2943854581
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Nonsteroidal anti-inflammatory drugs are pathogenetically substantiated for managing pelvic pain by reducing prostaglandins, aiding treatment of acute pelvic infections and idiopathic menstrual pain.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

The paper reviews evidence on the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for managing pelvic pain in women, drawing on prior studies and clinical guideline information across gynecologic pain conditions. It summarizes that NSAIDs are commonly used for primary dysmenorrhea and discusses the broader inflammatory and pain mechanisms that can underlie pelvic pain, while also referencing an existing Cochrane review specifically on NSAIDs for endometriosis-related pain. The authors’ main limitation is that this is a narrative review that synthesizes heterogeneous sources rather than presenting new original data, so the conclusions depend on the quality and scope of the included literature. Relevance to endometriosis: it explicitly cites and discusses prior evidence from a Cochrane review of “Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis,” though the paper’s main focus is NSAID use for pelvic pain in women more broadly.

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Abstract

Pelvic pain is one of the common causes for visiting a doctor, which can be the main symptom of gynecological diseases and an independent pathological condition. Acute pelvic pain is most often caused by an infection that affects the organs of a woman’s reproductive system. Non-infectious causes of pain are also associated with inflammation, and estrogens support pain and inflammation in women, which increases the risk of chronic pelvic pain (CPP). The urgency of the pelvic pain problem is considered not only in connection with an adequate diagnosis of its causes, but also from the perspective of managing the pain symptoms themselves. The anaesthesia strategy significantly improves the quality of life and prevents the development of chronic inflammatory diseases and CPP syndrome. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in pain therapy, and their effect consists in reducing the synthesis of prostaglandins and is pathogenetically substantiated both in the complex treatment of acute pelvic infections and in the treatment of idiopathic menstrual pain. The article presents clinical observations of the use of NSAIDs with the specified purpose.
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Нестероидные противовоспалительные средства в терапии женской тазовой боли https://doi.org/10.21518/2079-701X-2019-7-27-32 Аннотация Об авторах И. В. КузнецоваРоссия Кузнецова Ирина Всеволодовна – д.м.н., кафедры акушерства и гинекологии № 1 лечебного факультета. 119991, Россия, г. Москва, ул. Трубецкая, д. 8, стр. 2. Л. В. Евсюкова Россия Евсюкова Людмила Владимировна – к.м.н., кафедры акушерства и гинекологии. 390026, Россия, г. Рязань, ул. Высоковольтная, д. 9. Список литературы 1. Gunter J. Neurobiology of chronic pelvic pain. In: Chronic Pelvic Pain, ed. P. Vercellini; Blackwell Publishing, London, UK, 2011:1–6. 2. Воробьева О.В. Хронические тазовые боли: фокус на миофасциальный болевой синдром мышц тазового дна. Consilium medicum. 2012;6(14):14-18. [Vorobeva O.V. Chronic pelvic pain: focus on myofascial pain syndrome in the pelvic floor muscles. Consilium medicum. 2012;6(14):14-18.] (In Russ). 3. Ведение больных инфекциями, передаваемыми половым путем, и урогенитальными инфекциями. Клинические рекомендации Российского общества дерматовенерологов и косметологов. М.: Деловой экспресс, 2012. 112 с. [Management of patients with sexually transmitted infections and urogenital infections. Clinical guidelines of the Russian Society of Dermatovenerologists and Cosmetologists. M.: Business Express, 2012. 112 p.] (In Russ). 4. Ross J., Guaschino S., Cusini M., Jensen J. 2017 European guideline for the management of pelvic inflammatory disease. Int J STD AIDS. 2018;29(2):108–114. 5. Roongsitthichai A., Srisuwatanasagul S., Koonjaenak S., Tummaruk P. Expression of cyclooxygenase-2 in the endometrium of gilts with different stages of endometritis. J Vet Med Sci. 2011;73(11):1425–1431. 6. Lee C.H., Roh J.W., Choi J.S. et al. Cyclooxygenase-2 is an independent predictor of poor prognosis in uterine leiomyosarcomas. Int J Gynecol Cancer. 2011;21(4):668–672. 7. Dhasmana D., Hathorn E., McGrath R., Tariq A., Ross J. The effectiveness of nonsteroidal anti-inflammatory agents in the treatment of pelvic inflammatory disease: a systematic review. Syst Rev. 2014;3:79. 8. Marjoribanks J., Proctor M.L., Farquhar C., Derks R.S. Nonsteroidal anti-inflammatory drugs for primary dysmenorrhoea. Cochrane Database Syst. Rev. 2010;1:CD001751. 9. Ju H., Jones M., Mishra G. The prevalence and risk factors of dysmenorrhea. Epidemiol Rev. 2014;36:104–113. 10. Lousse J.C., Langendonckt A.V., Defrere S., et al. Peritoneal endometriosis is an inflammatory disease. Front Biosci. 2012;4(1):23–40. 11. Laschke M.W., Giebels C., Menger M.D. Vasculogenesis: a new piece of the endometriosis puzzle. Hum Reprod Update. 2011;17(5):628–636. 12. Iacovides S., Avidon I., Baker F.C. What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update. 2015;6:762–778. 13. Chaban V. Estrogen and visceral nociception at the level of primary sensory neurons. Pain Res Treat. 2012;2012:906780. 14. Wiech K., Tracey I. Influence of negative emotions on pain: behavioral effects and neural mechanisms. Neuroimage. 2009;47:987–994. 15. Craig K.D., Versloot J., Goubert et al. Perceiving pain in others: automatic and controlled mechanisms. Pain. 2010;11(2):101–108. 16. Allen C., Hopewell S., Prentice A., Gregory D. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst. Rev. 2009;2:CD004753. 17. Каратеев А.Е., Яхно Н.Н., Лазебник Л.Б. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М.: ИМА-ПРЕСС, 2009:9. [Karateev A.E., Yakhno N.N., Lazebnik L.B, et al. Use of nonsteroidal anti-inflammatory drugs. Clinical guidelines. M.: IMA-PRESS, 2009: 9.p] (In Russ). 18. Кулагина Н.В. Спазмолитическая терапия в лечении первичной дисменореи. Гинекология. 2011;3(13):28–31. [Kulagina N.V. Antispasmodic therapy in the treatment of primary dysmenorrhea. Ginekologiya. 2011;3(13): 28–31.] (In Russ). 19. Daniels S., Robbins J., West C.R. et al. Celecoxib in the treatment of primary dysmenorrhea: results from two randomized, double-blind, active- and placebo- controlled, crossover studies. Clin Ther. 2009;31:1192–1208. 20. Latthe P.M., Champaneria R. Dysmenorrhoea. BMJ Clin Evid. 2014;2014:0813. 21. Livshits A., Seidman D.S. Role of Non-steroidal antiinflammatory drugs in gynecology. Pharmaceuticals (Basel). 2010;3(7):2082–2089. 22. Falcone T., Lebovic D.I. Clinical management of endometriosis. Obstet Gynecol. 2011;118(3):691–705. Рецензия Для цитирования: Кузнецова ИВ, Евсюкова ЛВ. Нестероидные противовоспалительные средства в терапии женской тазовой боли. Медицинский Совет. 2019;(7):27-33. https://doi.org/10.21518/2079-701X-2019-7-27-32 For citation: Kuznetsova IV, Evsyukova LV. Nonsteroidal anti-inflammatory drugs for management of pelvic pain in women. Meditsinskiy sovet = Medical Council. 2019;(7):27-33. (In Russ.) https://doi.org/10.21518/2079-701X-2019-7-27-32 JATS XML

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