Effects of Danazol on Mineral Homeostasis in Normal Postmenopausal Women: Preliminary Communication

D.W. Purdie; Purdie DW; Alastair Hay; Hay A; Abbas SK; S.K. Abbas

doi:10.1177/014107688708001107

Effects of Danazol on Mineral Homeostasis in Normal Postmenopausal Women: Preliminary Communication

D.W. Purdie, Purdie DW, Alastair Hay, Hay A, Abbas SK, S.K. Abbas

Journal of the Royal Society of Medicine · 1987 · vol. 80(11) , pp. 681–682 · doi:10.1177/014107688708001107 · PMID:3694613 · PMC1291087 · W1895561218

article OA: bronze CC0 ⤵ 2 in-corpus citations

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This study found that 800 mg/day of danazol in postmenopausal women significantly lowered plasma ionized calcium and urinary calcium, suggesting inhibition of bone resorption and phosphate retention without affecting liver function.

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Abstract

The effects of danazol on calcium homeostasis in normal postmenopausal women was examined in a 14-day study utilizing a dosage of 800 mg per day. Danazol caused significant falls in plasma ionized calcium and in the fasting urinary calcium/creatinine ratio, indicating inhibition of bone resorption. Retention of phosphate was also observed as expected with this anabolic agent. The plasma total alkaline phosphatase was also depressed by the drug, which had no effect on hepatocellular function as measured by plasma AST. Certain effects induced by treatment with danazol were still apparent two weeks after cessation of treatment. The drug was well tolerated and androgenic side effects were not seen. It is suggested that the minimal dose regimen of danazol which exerts a calcium-sharing effect should be identified, and that this regimen should be considered for use in a prospective study of the effects of danazol on bone mineral content in the postmenopause.

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Cites (1)

Danazol—a Synthetic Steroid Derivative with Interesting Physiologic Properties 1971

Cited by (1)

Danazol-induced hypercalcaemia in alphacalcidol-treated hypoparathyroidism 1989

References (7)

Danazol—a Synthetic Steroid Derivative with Interesting Physiologic Properties via openalex
doi:10.1042/cs0690265 via openalex
doi:10.1056/nejm197902013000502 via openalex
doi:10.1016/0026-0495(83)90027-6 via openalex
doi:10.1042/cs0540193 via openalex
doi:10.1016/0026-0495(81)90050-0 via openalex
W2910567225 via openalex

Cited by (1)

Danazol-induced hypercalcaemia in alphacalcidol-treated hypoparathyroidism 1989

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[1] Danazol—a Synthetic Steroid Derivative with Interesting Physiologic Properties 1971