Anionic powdered-nanoliposome loaded with algal oil: Effects of carrier agents on storage stability, in-vitro digestibility and cellular uptake

Present study prepared anionic powdered-nanoliposomes loaded with algal oil using phosphatidylserine and different wall materials (maltodextrin and hydroxypropyl β-cyclodextrin). All the powdered liposomes were nanosized (238.97 ± 4.67–256.30 ± 0.85 nm) with negative zeta potential (-71.80 ± 7.84 – -51.46 ± 1.27 mv). We have investigated and compared the effects of different wall materials on the oxidative stability, in-vitro digestibility and cellular uptake of the spray-dried powders were investigated. Results showed MD was able to provide higher oxidative stability to anionic-powdered liposomes loaded with algal oil. In addition, powdered liposomes produced from MD demonstrated better in-vitro digestibility with increased in SLC27A4, FABP2 and CD36 gene expression indicating good cellular uptake of the powdered liposomes.