Study on the expression and significance of subtypes of 14-3-3 protein mRNA in adenomyosis

Objective:To investigate what role do 14-3-3 proteins play in the development of human adenomyosis by detecting the expression of 14-3-3 proteins mRNA in adenomyosis.Methods:Reverse transcription polymerase chain reaction was used to detect the expression of 14-3-3 proteins mRNA in normal endometrium,eutopic endometrium and ectopic endometrium with adenomyosis.Results:The expression of 14-3-3θ,e and ζ mRNA in eutopic and (or) ectopic endometrium with adenomyosis was up regulation when compared with normal endometrium.Conclusion:The abnormal expression of those three isoforms of 14-3-3 proteins may be involved in the development of adenomyois.