Aluminum-based salts: a novel and simple way to treat molluscum contagiosum and cutaneous warts

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Camargo" } ], "publisher": { "@type": "Organization", "name": "F1000Research", "logo": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 480, "width": 60 } }, "image": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 1200, "width": 150 }, "description": "Molluscum contagiosum and human papillomavirus (HPV) are very common cutaneous infections with worldwide distribution, yet treatment options remain limited. Traditional therapies are invasive and have a high rate of recurrence, and newer topical agents available are costly. Here I discuss evidence supporting the hypothesis that the aluminum-based salts, utilized in the antiperspirant industry since the early 1900s, could have a therapeutic effect on skin lesions due to molluscum contagiosum, HPV and possibly other viruses. Clinical trials in this area are needed." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/14-1340", "name": "Aluminum-based salts: a novel and simple way to treat molluscum contagiosum..." } } ] } Home Browse Aluminum-based salts: a novel and simple way to treat molluscum contagiosum... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Camargo JF. Aluminum-based salts: a novel and simple way to treat molluscum contagiosum and cutaneous warts [version 1; peer review: 1 approved] . F1000Research 2025, 14 :1340 ( https://doi.org/10.12688/f1000research.173851.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Opinion Article Aluminum-based salts: a novel and simple way to treat molluscum contagiosum and cutaneous warts [version 1; peer review: 1 approved] Jose F. Camargo https://orcid.org/0000-0001-9584-5011 Jose F. Camargo https://orcid.org/0000-0001-9584-5011 PUBLISHED 01 Dec 2025 Author details Author details Division of Infectious Diseases, University of Miami Department of Medicine, Miami, Florida, 33136, USA Jose F. Camargo Roles: Conceptualization, Investigation, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS Abstract Molluscum contagiosum and human papillomavirus (HPV) are very common cutaneous infections with worldwide distribution, yet treatment options remain limited. Traditional therapies are invasive and have a high rate of recurrence, and newer topical agents available are costly. Here I discuss evidence supporting the hypothesis that the aluminum-based salts, utilized in the antiperspirant industry since the early 1900s, could have a therapeutic effect on skin lesions due to molluscum contagiosum, HPV and possibly other viruses. Clinical trials in this area are needed. READ ALL READ LESS Keywords aluminum, molluscum contagiosum, human papillomavirus, verruca vulgaris, warts Corresponding Author(s) Jose F. Camargo ( [email protected] ) Close Corresponding author: Jose F. Camargo Competing interests: Listed in the corresponding section of the manuscript In the past five years, Jose F. Camargo has received consultation honoraria from Gilead, GlaxoSmithKline and Merck. He has also been a paid speaker for Merck. Dr. Camargo has filed a patent application related to the material discussed in this manuscript. The opinions expressed in this article are those of the author and do not reflect the views, participation, support or endorsement of his academic institution. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2025 Camargo JF. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Camargo JF. Aluminum-based salts: a novel and simple way to treat molluscum contagiosum and cutaneous warts [version 1; peer review: 1 approved] . F1000Research 2025, 14 :1340 ( https://doi.org/10.12688/f1000research.173851.1 ) First published: 01 Dec 2025, 14 :1340 ( https://doi.org/10.12688/f1000research.173851.1 ) Latest published: 01 Dec 2025, 14 :1340 ( https://doi.org/10.12688/f1000research.173851.1 ) Cutaneous human papillomavirus (HPV) infections are ubiquitous in the general population. Nearly everyone will get HPV at some point in their lives. Up to 90% of healthy individuals test positive for beta HPV types. 1 Numerous treatments for nongenital cutaneous warts are available, although no single therapy has been established as completely curative; this is portrayed by the fact that even duct tape is considered a treatment option. 2 Molluscum contagiosum (MC) is another cutaneous viral infection with prevalence in the U.S. general population of approximately 5%, affecting primarily pediatric patients, sexually active young adults, and immunocompromised people of all ages. 3 Spontaneous resolution can take months to years impacting the quality of life of patients and caregivers. Traditional therapies are invasive and have a high rate of recurrence. In the last two years, however, the Food and Drug Administration (FDA) approved two topical agents to treat MC. The efficacy difference of the study drugs compared to the vehicle (placebo) in the trials was 28-41% for cantharidin, 4 and 13% for berdazimer gel. 5 Immunocompromised hosts were excluded from these clinical trials and no data on recurrence was reported. Notably, both agents are considerably expensive and, in some cases, must be given for up to 12 weeks. I am now an infectious diseases specialist with over a decade of experience, but 25 years ago, while still in my third year of medical school, I noticed that my youngest brother, age 11 at the time, had 2 small non-painful non-itchy pearly skin lesions right below his armpit at the level the midaxillary line. I thought it was a case of MC; I reassured him and explained it would probably go away within a few months. Around the same time, he began experiencing puberty sweat and he did not hesitate in using my roll-on deodorant (I cannot remember the brand, but I remember its green pine color). Within days of using deodorant, I was amazed to notice how his skin lesions rapidly cleared up. Last year, my 10-year-old daughter had a 1 cm rough-surface wart at the lateral aspect of the 4 th distal interphalangeal joint that had been present for months. Without pursuing draconian IRB proceedings and without much published scientific literature to support my hypothesis, I started applying deodorant gel (active ingredient: aluminum zirconium octachlorohydrex Gly 16%; inactive ingredients: water, denatured alcohol, cyclopentasiloxane, propylene glycol, dimethicone, calcium chloride, PEG/PPG-18/18 dimethicone, fragrance) once or twice a day to the lesion. Within less than two weeks, the wart was notably better in size and height, and within four weeks it had nearly resolved. More recently, encouraged by these results, I applied the same deodorant gel, once a day, to a small (2-3 mm) dome-shaped pearly papule in the right nasolabial fold of my 7-year-old daughter, which I thought was MC; within 5-6 applications, the lesion completely disappeared. I am now convinced that the antiperspirant salts shortened the duration of symptoms in these three cases. Although the terms antiperspirant and deodorant are often used interchangeably, they are not synonyms. Deodorants target bacteria that create odors while antiperspirants contain aluminum-based salts that form a colloidal plug preventing, temporarily, the eccrine glands from releasing sweat. 6 , 7 In addition to the anecdotal evidence mentioned above, the following observations provide circumstantial evidence supporting the possibility that the aluminum-based salts, utilized in the antiperspirant industry since the early 1900s, 6 , 7 could have a beneficial effect on skin lesions due to MC, HPV and possibly other viruses: 1. Today over 90% of the U.S. population uses some form of underarm antiperspirant daily; 7 and although it has been reported, HPV associated warts involving the armpit are an extremely rare occurrence. 8 , 9 2. Aluminum salts (administered by mouth) shortened the duration of symptoms and had beneficial effects on laboratory findings in patients with COVID-19. 10 3. In Turkey, animals suffering from foot and mouth disease are treated, presumably quite successfully, with the topical use of aluminum salts; 10 and in animal models, intranasal administration of aluminum-based adjuvants alone can prevent influenza or respiratory syncytial virus by activating the alveolar macrophage and type I interferon pathway components of the innate immune system. 11 4. Aluminum (Al2O3), zirconium (ZrO2), and cerium (CeO2) oxides nanoparticles exhibit high affinity for human-pathogenic viruses 12 such as adenovirus and human immunodeficiency virus type 1; and can sequester viral nucleic acids from aqueous solutions. 12 , 13 Al2O3 nanoparticles have a robust antiviral activity against herpes simplex virus-1 in vitro. 14 In addition, inorganic nanoparticles may also exert direct virucidal activity through various mechanisms. 15 5. Aluminum-based salts have been proven to enhance the immune response. Since the 1930s aluminum-based salts (hydroxide or phosphate) have been used as adjuvants for numerous human vaccines, 16 including the HPV vaccine (Gardisil 9). AS04 is a combination of the toll-like receptor 4 agonist monophosphoryl lipid A (MPL) and aluminum hydroxide. The AS04-adjuvanted HPV vaccine induces a high and sustained immune response against HPV. 17 Other examples of aluminum-containing vaccines are listed in the U.S. Centers for Disease Control and Prevention (CDC) website, and include DTaP (Daptacel), DTaP (Infanrix), DTaP-HepB-IPV (Pediarix), DTaP-IPV (Kinrix), DTaP-IPV (Quadracel), DTaP –IPV/Hib (Pentacel), DTaP-IPV-Hib-HepB (VAXELIS), HepA (Havrix), HepA (Vaqta), HepB (Engerix-B), HepB (Recombivax), HepA/HepB (Twinrix), HIB (PedvaxHIB), Japanese encephalitis (Ixiaro), MenB (Bexsero, Trumenba), Pneumococcal (Prevnar 13, Prevnar 20, VAXNEUVANCE), Td (Tenivac), Tdap (Adacel), Tdap (Boostrix), and Tick-Borne Encephalitis (TICOVAC). Aluminum enhances antigen uptake by antigen-presenting cells and stimulates components of the inflammasome. 16 , 18 , 19 Aluminum hydroxide also prolongs the cytokine responses at the injection site and induces chemokine (namely CCL2) production. 16 , 18 , 19 These effects of aluminum salt have been linked to monocyte differentiation and migration to draining lymph nodes and augmented humoral response. 16 , 18 , 19 6. Aluminum-based salts have been used with promising results in small case series of verruca vulgaris. Alum (potassium aluminum sulfate) solution was effective in the treatment of common warts in two patients from Iran. 20 In a more recent report from Turkey, four patients with cryotherapy resistant HPV warts were successfully treated with an 18% aluminum chloride solution. 21 The authors proposed that aluminum chloride solution acted as an astringent with keratolytic effect in the virus-infected epidermis. But are aluminum salts safe? Aluminum salts are common in nature and are also found in drinking water in trace amounts; and have been used for many years as ingredients in drugs, natural health products and cosmetics. 10 It is estimated that only 0.0005 to 0.012% of applied aluminum in an antiperspirant formulation is absorbed through the skin. 22 , 23 In addition, aluminum-containing adjuvants have been used for nearly a century in vaccines injected into more than 1 billion people worldwide without safety concerns. 16 Some of the paramount advancements in medicine have been the result of basic clinical observations. In 1796, Edward Jenner, considered the father of immunology, inoculated an 8-year-old with matter from a cowpox sore on the hand of a local milkmaid, merely based on tales of dairymaids being naturally protected from smallpox after cowpox. The child did not only experience a full recovery but also became immune to smallpox. 24 Smallpox would become the first and only infectious disease eradicated through mass immunization. No, I do not believe that my observations are as important as those from the times of Jenner, nor that Windex has healing properties, 25 but I do strongly believe that aluminum-based salts might have salutatory effects on cutaneous viral infections. Serendipity has played a role in some of the most important medical discoveries in the last century. 26 Penicillin was discovered by accident; 26 remdesivir, the first FDA-approved antiviral for COVID-19, was originally developed for the treatment of Ebola virus; 27 sildenafil (Viagra) was initially developed as an anti-angina medication; 26 warfarin was initially developed as rat poison; 26 and among these lines, it might just be that an inexpensive, effective (conceivable better than duct tape) and well tolerated topical treatment for MC or cutaneous warts has been hiding in your bathroom cabinet all along. The role of aluminum-based salts in the treatment of MC, HPV and other skin viral infections deserves further study. Data availability No data associated with this article. Acknowledgements The author is indebted to Dr. Gary Wormser at New York Medical College for manuscript review and insightful advice. References 1. Gheit T, et al. : Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology. Front. Oncol. 2010; 9 (355): 1–22. 2. Mulhem E, Pinelis S: Treatment of Nongenital Cutaneous Warts. Am. Fam. Physician. 2011; 84 (3): 288–293. PubMed Abstract 3. Hebert AA, Bhatia N, Del Rosso JQ: Molluscum Contagiosum: Epidemiology, Considerations, Treatment Options, and Therapeutic Gaps. J. Clin. Aesthet. Dermatol. 2023; 16 (8 Suppl 1): S4–S11. PubMed Abstract 4. Eichenfield LF, McFalda W, Brabec B, et al. : Safety and Efficacy of VP-102, a Proprietary, Drug-Device Combination Product Containing Cantharidin, 0.7% (w/v), in Children and Adults With Molluscum Contagiosum. Two Phase 3 Randomized Clinical Trials. JAMA Dermatol. 2020; 156 (12): 1315–1319. Publisher Full Text 5. Browning JC, Enloe C, Cartwright M, et al. : Efficacy and Safety of Topical Nitric Oxide−Releasing Berdazimer Gel in Patients With Molluscum. JAMA Dermatol. 2022; 158 (8): 871–878. PubMed Abstract | Publisher Full Text 6. Teerasumran P, Velliou E, Bai S, et al. : Deodorants and antiperspirants: New trends in their active agents and testing methods. Int. J. Cosmet. Sci. 2023; 45 (4): 426–443. PubMed Abstract | Publisher Full Text | Free Full Text 7. Antiperspirants and Deodorants: Principles of Underarm Technology. International Federation of the Societies of Cosmetic Chemists (IFSCC) monograph number 6. Weymouth, Dorset, England: Micelle Press; 1998. 8. Kuraishi N, Shimizu A, Kato M, et al. : Giant condyloma acuminatum in the axilla. Acta Derm. Venereol. 2015; 95 (3): 355–356. PubMed Abstract | Publisher Full Text 9. Hsu T, Nahmias ZP, Rosman IS, et al. : Extragenital condyloma acuminatum in the left axillary vault. JAAD Case Rep. 2018; 4 (9): 947–949. PubMed Abstract | Publisher Full Text | Free Full Text 10. Demir A, Erayman I, Dogan O, et al. : Influence of aluminum salts on COVID-19 infected patients. Turk. J. Med. Sci. 2020; 50 (8): 1771–1780. PubMed Abstract | Publisher Full Text | Free Full Text 11. Wang X, Yin X, Zhang B, et al. : A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity. Emerg. Microbes Infect. 2022; 11 (1): 914–925. PubMed Abstract | Publisher Full Text | Free Full Text 12. Link N, Brunner TJ, Dreesen I, et al. : Inorganic nanoparticles for transfection of mammalian cells and removal of viruses from aqueous solutions. Biotechnol. Bioeng. 2007; 98 (5): 1083–1093. PubMed Abstract | Publisher Full Text 13. Christensen E, Myrmel M: Coagulant residues’ influence on virus enumeration as shown in a study on virus removal using aluminium, zirconium and chitosan. J. Water Health. 2018; 16 (4): 600–613. PubMed Abstract | Publisher Full Text 14. Almansorri AK, Al-Shirifi H, Al-Musawi S, et al. : Investigation of the Inhibition Activity of Aluminium Oxide Nanoparticles for Herpes Simplex Type 1. Arch. Razi Inst. 2023; 78 (1): 213–219. PubMed Abstract | Publisher Full Text 15. Shcherbakov AB: CeO 2 nanoparticles and cerium species as antiviral agents: Critical review. European Journal of Medicinal Chemistry Reports. 2024; 10 : 100119–100141. Publisher Full Text 16. HogenEsch H, O’Hagan DT, Fox CB: Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want. NPJ Vaccines. 2018; 3 (51): 1–11. Publisher Full Text 17. Garçon N, Morel S, Didierlaurent A, et al. : Development of an AS04-adjuvanted HPV vaccine with the adjuvant system approach. BioDrugs. 2011; 25 (4): 217–226. PubMed Abstract | Publisher Full Text 18. Didierlaurent AM, Morel S, Lockman L, et al. : AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J. Immunol. 2009; 183 (10): 6186–6197. PubMed Abstract | Publisher Full Text 19. Kool M, Soullié T, van Nimwegen M , et al. : Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J. Exp. Med. 2008; 205 (4): 869–882. PubMed Abstract | Publisher Full Text | Free Full Text 20. Saburi E, Behdari A: Successful treatment of common warts with alum. Anc. Sci. Life. 2018; 37 : 214–216. 21. Yıldırım KPH, Hasanbeyzade S, Tanaçan E, et al. : Successful Treatment of Cryotherapy Resistant Verruca Vulgaris with 18% Aluminum Chloride Solution: A Report of 4 Cases. Indian Dermatol. Online J. 2025; 16 (3): 432–434. PubMed Abstract | Publisher Full Text | Free Full Text 22. Flarend R, Bin T, Elmore D, et al. : A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26. Food Chem. Toxicol. 2001; 39 (2): 163–168. PubMed Abstract | Publisher Full Text 23. de Ligt R , Westerhout J, Grossouw D, et al. : Assessment of dermal absorption of aluminium from a representative antiperspirant formulation using a (26Al) Al microtracer approach: a follow-up study in humans. Toxicol Res. (Camb). 2022; 11 (3): 511–519. PubMed Abstract | Publisher Full Text | Free Full Text 24. Riedel S: Edward Jenner and the history of smallpox and vaccination. Proc. (Baylor Univ. Med. Cent.). 2005; 18 (1): 21–25. PubMed Abstract | Publisher Full Text | Free Full Text 25. Is Windex actually a cure-all? The ‘My Big Fat Greek Wedding’ joke, explained. Nicoletta Richardson. 2023. Accessed Nov 16, 2025. Reference Source 26. Happy Accidents: Serendipity in Modern Medical Breakthroughs. Meyers, Morton A. New York, NY: Arcade Publishing; 2007. 27. Pardo J, Shukla AM, Chamarthi G, et al. : The journey of remdesivir: from Ebola to COVID-19. Drugs Context. 2020; 9 : 1–9. Publisher Full Text Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 01 Dec 2025 ADD YOUR COMMENT Comment Author details Author details Division of Infectious Diseases, University of Miami Department of Medicine, Miami, Florida, 33136, USA Jose F. Camargo Roles: Conceptualization, Investigation, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests Listed in the corresponding section of the manuscript In the past five years, Jose F. Camargo has received consultation honoraria from Gilead, GlaxoSmithKline and Merck. He has also been a paid speaker for Merck. Dr. Camargo has filed a patent application related to the material discussed in this manuscript. The opinions expressed in this article are those of the author and do not reflect the views, participation, support or endorsement of his academic institution. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (1) version 1 Published: 01 Dec 2025, 14:1340 https://doi.org/10.12688/f1000research.173851.1 Copyright © 2025 Camargo JF. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Camargo JF. Aluminum-based salts: a novel and simple way to treat molluscum contagiosum and cutaneous warts [version 1; peer review: 1 approved] . F1000Research 2025, 14 :1340 ( https://doi.org/10.12688/f1000research.173851.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 01 Dec 2025 Views 0 Cite How to cite this report: Al-Muriesh M and Abdul fattah B. Reviewer Report For: Aluminum-based salts: a novel and simple way to treat molluscum contagiosum and cutaneous warts [version 1; peer review: 1 approved] . F1000Research 2025, 14 :1340 ( https://doi.org/10.5256/f1000research.191704.r452166 ) The direct URL for this report is: https://f1000research.com/articles/14-1340/v1#referee-response-452166 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 29 Jan 2026 Maher Al-Muriesh , Sana’a University, Sana’a, Yemen Bilal Abdul fattah , Chtoura Hospital, chtoura, Lebanon Approved VIEWS 0 https://doi.org/10.5256/f1000research.191704.r452166 The manuscript is well written some suggestions : Aluminum-based salts were used previously in the literature to treat cutaneous warts. Therefore, in this manuscript, delete 'cutaneous wart' from the title if you want to ... Continue reading READ ALL The manuscript is well written some suggestions : Aluminum-based salts were used previously in the literature to treat cutaneous warts. Therefore, in this manuscript, delete 'cutaneous wart' from the title if you want to keep the word ( novel). Because the manuscript is an opinion article, it is not mandatory to add images of the case, although adding before-and-after treatment figures would strengthen the article. Is the topic of the opinion article discussed accurately in the context of the current literature? Partly Are all factual statements correct and adequately supported by citations? Yes Are arguments sufficiently supported by evidence from the published literature? Yes Are the conclusions drawn balanced and justified on the basis of the presented arguments? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: dermatology We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Al-Muriesh M and Abdul fattah B. Reviewer Report For: Aluminum-based salts: a novel and simple way to treat molluscum contagiosum and cutaneous warts [version 1; peer review: 1 approved] . F1000Research 2025, 14 :1340 ( https://doi.org/10.5256/f1000research.191704.r452166 ) The direct URL for this report is: https://f1000research.com/articles/14-1340/v1#referee-response-452166 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 30 Jan 2026 Jose Camargo , Division of Infectious Diseases, University of Miami Department of Medicine, Miami, 33136, USA 30 Jan 2026 Author Response I thank the reviewer for his insightful comments and suggestions. I agree with the first suggestion, and the title will be edited accordingly (only waiting for additional reports before starting ... Continue reading I thank the reviewer for his insightful comments and suggestions. I agree with the first suggestion, and the title will be edited accordingly (only waiting for additional reports before starting on any article revisions). Unfortunately, since these anecdotal observations occurred in a personal -not hospital- setting, no pictures are available. I thank the reviewer for his insightful comments and suggestions. I agree with the first suggestion, and the title will be edited accordingly (only waiting for additional reports before starting on any article revisions). Unfortunately, since these anecdotal observations occurred in a personal -not hospital- setting, no pictures are available. Competing Interests: No competing interests were disclosed. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 30 Jan 2026 Jose Camargo , Division of Infectious Diseases, University of Miami Department of Medicine, Miami, 33136, USA 30 Jan 2026 Author Response I thank the reviewer for his insightful comments and suggestions. I agree with the first suggestion, and the title will be edited accordingly (only waiting for additional reports before starting ... Continue reading I thank the reviewer for his insightful comments and suggestions. I agree with the first suggestion, and the title will be edited accordingly (only waiting for additional reports before starting on any article revisions). Unfortunately, since these anecdotal observations occurred in a personal -not hospital- setting, no pictures are available. I thank the reviewer for his insightful comments and suggestions. I agree with the first suggestion, and the title will be edited accordingly (only waiting for additional reports before starting on any article revisions). Unfortunately, since these anecdotal observations occurred in a personal -not hospital- setting, no pictures are available. Competing Interests: No competing interests were disclosed. Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 01 Dec 2025 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 Version 1 01 Dec 25 read Maher Al-Muriesh , Sana’a University, Sana’a, Yemen Bilal Abdul fattah , Chtoura Hospital, chtoura, Lebanon Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2026 Al-Muriesh M et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 29 Jan 2026 | for Version 1 Maher Al-Muriesh , Sana’a University, Sana’a, Yemen Bilal Abdul fattah , Chtoura Hospital, chtoura, Lebanon 0 Views copyright © 2026 Al-Muriesh M et al. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The manuscript is well written some suggestions : Aluminum-based salts were used previously in the literature to treat cutaneous warts. Therefore, in this manuscript, delete 'cutaneous wart' from the title if you want to keep the word ( novel). Because the manuscript is an opinion article, it is not mandatory to add images of the case, although adding before-and-after treatment figures would strengthen the article. Is the topic of the opinion article discussed accurately in the context of the current literature? Partly Are all factual statements correct and adequately supported by citations? Yes Are arguments sufficiently supported by evidence from the published literature? Yes Are the conclusions drawn balanced and justified on the basis of the presented arguments? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise dermatology We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (1) Author Response 30 Jan 2026 Jose Camargo, Division of Infectious Diseases, University of Miami Department of Medicine, Miami, 33136, USA I thank the reviewer for his insightful comments and suggestions. I agree with the first suggestion, and the title will be edited accordingly (only waiting for additional reports before starting on any article revisions). Unfortunately, since these anecdotal observations occurred in a personal -not hospital- setting, no pictures are available. View more View less Competing Interests No competing interests were disclosed. reply Respond Report a concern Al-Muriesh M and Abdul fattah B. Peer Review Report For: Aluminum-based salts: a novel and simple way to treat molluscum contagiosum and cutaneous warts [version 1; peer review: 1 approved] . F1000Research 2025, 14 :1340 ( https://doi.org/10.5256/f1000research.191704.r452166) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-1340/v1#referee-response-452166 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. 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