Pathogenetic treatment strategies in nulliparous women with ovarian endometriomas

The modern approach to the treatment options and assessment of its effectiveness in nulliparous women with endometrial cysts is build on optimal pathogenetically substantiated therapy based on features of the disease not only on the system, organ and tissue levels, and taking to consideration the cellular and molecular features of the functioning of the body. The objective: to determine the effectiveness of various treatment regimens for nulliparous women with ovary tumor-like formations based on features of the immune status. Materials and methods. 80 women aged 17 to 40 years were examined: the first group consisted of 50 healthy nonpregnant women, the second group included 30 women, with endometriomas receiving the traditional (subgroup 2a) and complex (subgroup 2b) treatment. Results. In the study of immune status in nulliparous women with endometrioid tumor-like formations of ovaries (n=30) was the inconsistency of the phagocytic system, the imbalance of T- and B-cell immunity, dysimmunoglobulinemy. Based on the identification of changes, the patients were assigned with pathogenetically substantiated combination therapy that included, in addition to conventional treatment regimens, the appointment of immunomodulators and systemic enzyme therapy. Conclusions. Treatment results show the full normalization of phagocytic, T- and B-cells and partially humoral systems. Key words: immunomodulating therapy, nulliparous women, tumor-like endometrioid ovarian formation.