Pathogenetic treatment strategies in nulliparous women with ovarian endometriomas

O.S. Shapoval, L.L. Vorontsova
In: HEALTH OF WOMAN · 2019 · pp. 30–33 · doi:10.15574/hw.2019.141.30 · W4286432461
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This study evaluated the effectiveness of pathogenetically substantiated combination therapy for nulliparous women with ovarian endometriomas, focusing on immune status abnormalities. Researchers examined 80 participants, comparing a healthy control group against patients receiving traditional or complex treatment regimens that included immunomodulators and systemic enzyme therapy alongside conventional methods. The results demonstrated that adding immunomodulatory components led to the full normalization of phagocytic, T-cell, and B-cell functions, as well as partial improvement in humoral immunity, indicating superior outcomes compared to standard care alone. This paper is centrally about endometriosis — specifically the management of ovarian endometriomas using immunomodulatory strategies in nulliparous women.

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Abstract

The modern approach to the treatment options and assessment of its effectiveness in nulliparous women with endometrial cysts is build on optimal pathogenetically substantiated therapy based on features of the disease not only on the system, organ and tissue levels, and taking to consideration the cellular and molecular features of the functioning of the body. The objective: to determine the effectiveness of various treatment regimens for nulliparous women with ovary tumor-like formations based on features of the immune status. Materials and methods. 80 women aged 17 to 40 years were examined: the first group consisted of 50 healthy nonpregnant women, the second group included 30 women, with endometriomas receiving the traditional (subgroup 2a) and complex (subgroup 2b) treatment. Results. In the study of immune status in nulliparous women with endometrioid tumor-like formations of ovaries (n=30) was the inconsistency of the phagocytic system, the imbalance of T- and B-cell immunity, dysimmunoglobulinemy. Based on the identification of changes, the patients were assigned with pathogenetically substantiated combination therapy that included, in addition to conventional treatment regimens, the appointment of immunomodulators and systemic enzyme therapy. Conclusions. Treatment results show the full normalization of phagocytic, T- and B-cells and partially humoral systems. Key words: immunomodulating therapy, nulliparous women, tumor-like endometrioid ovarian formation.
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Materials

and methods. 80 women aged 17 to 40 years were examined: the first group consisted of 50 healthy nonpregnant women, the second group included 30 women, with endometriomas receiving the traditional (subgroup 2a) and complex (subgroup 2b) treatment. Results. In the study of immune status in nulliparous women with endometrioid tumor-like formations of ovaries (n=30) was the inconsistency of the phagocytic system, the imbalance of T- and B-cell immunity, dysimmunoglobulinemy. Based on the identification of changes, the patients were assigned with pathogenetically substantiated combination therapy that included, in addition to conventional treatment regimens, the appointment of immunomodulators and systemic enzyme therapy. Conclusions. Treatment results show the full normalization of phagocytic, T- and B-cells and partially humoral systems. Key words: immunomodulating therapy, nulliparous women, tumor-like endometrioid ovarian formation.

References

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