The safety and efficacy of the LAmbre left atrial appendage closure device in atrial fibrillation: a systematic review and meta-analysis

The LAmbre occluder is more convenient to operate than other left atrial appendage closures(LAAC), and it can adapt to different anatomy of left atrial appendage. However, some studies showed that Lambre occluder had a higher incidence of device-related thrombus(DRT). This meta-analysis aims to compare the safety and efficacy of the LAmbre occluder with other LAAC devices. Eligible studies were retrieved from PubMed, Embase and the Cochrane Library up to 1 July 2022 and reported the results. Five studies of a total of 607 patients were included in the meta-analysis. The LAmbre occluder was associated with higher rate of DRT(OR [95% CI] = 5.25 [1.21, 22.86], P =0.03; I2=0%). No significant differences were observed in the incidence of procedure-related death, pericardial effusion, chest pain, bleeding and vessel complication, contrast medium, fluoroscopy time ,death, stroke, bleeding events, systemic embolism and peri-device leakage. In conclusion, the LAmbre occluder had higher incidence of DRT than other LAAC devices, and there were no significant differences in stroke, bleeding events, and mortality.