RESEARCH OF TISSUE ACTIVITY OF METALLOPROTEINASES AT VARIOUS FORMS OF AN ADENOMYOSIS

С А Леваков, A P Korobeinikov, Т. А. Демура
In: Journal of Clinical Practice · 2010 · vol. 1(3) , pp. 52–55 · doi:10.17816/clinpract1352-55 · W2793633515
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This study found increased activation and expression of matrix metalloproteinases 2 and 9 in the stroma and myometrium of women with diffuse and nodal adenomyosis, with MMP-9 showing more intensive expression.

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This study investigated the enzymatic activity of matrix metalloproteinases 2 and 9 in uterine tissue samples from women in late perimenopause with diffuse and nodal forms of adenomyosis. Using immunohistochemical analysis on paraffin sections, the researchers quantified positively stained cells to assess expression levels across different degrees of myometrial lesion. The findings demonstrated increased activation and expression intensity of MMP-2 and MMP-9 in both adenomyosis subtypes, with notably higher MMP-9 expression observed in the stroma and myometrium. This paper is centrally about adenomyosis — specifically examining the role of matrix metalloproteinase expression in its diffuse and nodal pathological forms.

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Abstract

Enzymatic activity matrix metalloproteinase's 2 and 9 in an operational material (the amputated uteruses) concerning diffusive and nodal forms of an adenomyosis at women in the late genesial period was studied. Research was spent with use of an immunohistochemical method on paraffinic sections. Results of immunohistochemical reaction were estimated by a semiquantitative method in points by quantity of positively painted cells. Activation and expression intensifying gelatinase ММР2 and ММР9 has been shown at diffusive and nodal forms of an adenomyosis and their various degrees of a lesion of a myometrium. Also it has been shown, that in a stroma and myometriums at diffusive and nodal forms of an adenomyosis the expression gelatinanases ММР9 was more intensively.
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Abstract

Enzymatic activity matrix metalloproteinase's 2 and 9 in an operational material (the amputated uteruses) concerning diffusive and nodal forms of an adenomyosis at women in the late genesial period was studied. Research was spent with use of an immunohistochemical method on paraffinic sections. Results of immunohistochemical reaction were estimated by a semiquantitative method in points by quantity of positively painted cells. Activation and expression intensifying gelatinase ММР2 and ММР9 has been shown at diffusive and nodal forms of an adenomyosis and their various degrees of a lesion of a myometrium. Also it has been shown, that in a stroma and myometriums at diffusive and nodal forms of an adenomyosis the expression gelatinanases ММР9 was more intensively.

References

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