The study on the effects and side - effects of patients with adenomyosis implanted by Norplant

Objective To study the results of treatment by Norplant for patients with adenomyosis. Methods To observe the clinical effects and side - effects of 30 patients with adenomyosis implanted by Norplant by comparing the symptoms of dysmenorrhea, concentrations of serum CA125, sizes of uterus, changes of menstruation, body weight, blood pressure, laboratory parameters of liver and kidney function, as well as serum lipid. Results The symptoms of dysmenorrhea were relieved significantly, with a rate as 100% . The concentration of serum CA125 decreased significantly (P 0.01) , which lowered down to normal level six months after implantation, and maintained a lower level after that. The size of uteri was not different from those before treatment (P0.05) . The main side - effects were menstrual disorders, including vaginal spoting, menostaxis, menorrhagia, etc. Body weight, blood pressure, laboratory parameters of liver and kidney function and serum lipid were not significantly different from that before treatment. Conclusions Treatment of adenomyosis with Norplant is safe and effective, especially as a good conservative treatment for premenopausal patients.