Effects of clomiphene citrate on endometrial hyperplasia in the premenopausal female

Robert W. Kistner, John L. Lewis, Gillen J. Steiner
In: Cancer · 1966 · vol. 19(1) , pp. 115–126 · doi:10.1002/1097-0142(196601)19:1<115::aid-cncr2820190113>3.0.co;2-f · PMID:5948088 · W1990373572
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Abstract

Clomiphene was administered continuously in a dose of 100 to 200 mg daily for 16 to 18 months to 6 patients (5 approaching menopause and one postmenopausal) having endometrial hyperplasia with a presenting complaint of irregular and profuse bleeding. After cessation of clomiphene therapy the results were atypical secretory endometrium—2 patients; normal menstrual cycles—3 patients; spontaneous menopause—one patient. The therapeutic effects of clomiphene are temporary. If the ovary maintains its potential for follicular maturation and ovulation, a secretory phase will be induced in the endometrium which lasts 6 to 8 weeks. Endometrial atrophy then will develop and remain unchanged as long as therapy is continued. The major side effects of clomiphene are hot flashes and ovarian cysts.

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