Comparative study of different doses of mifepristone in patients with uterine adenomyosis

Objective To explore the clinical effect and safety of different doses of mifepristone on the treatment of uterine adenomyosis patients.Methods A hundred and six patients with uterine adenomyosis were randomly divided into two groups including group A(n=54) and group B(n=52),which were given mifepristone for 6.25 mg·d-1 and 12.5 mg·d-1,respectively,once daily,3 months for a course of treatment.The clinical effect,change of volume of uterus and level of CA125,and adverse effect were observed and compared.Results After treatment,the total effective rate in group A and group B was not statistically different(94.4% vs.98.1%).The menstrual cycle,menstruation and degree of dysmenorrhea in both groups were significantly improved compared with those before treatment(P0.05),while there were not significant difference between group A and group B(P0.05).The volume of uterus and level of CA125 was significantly reduced compared with that before treatment(P0.05).The rate of adverse effect in group A and group B was 7.4% and 21.2%,which was significantly different(P0.05).Conclusion The treatment doses of 6.25 mg·d-1 mifepristone for uterine adenomyosis patients can be effective to reduce the adverse effect and improve patients' tolerance.