Primary Splenic Diffuse Large B Cell Lymphoma A case report and literature review of a rare condition

Abstract Primary splenic lymphoma represents a rare lymphoproliferative disorder that involves the spleen, exhibiting diverse clinical presentations and lacking a clear consensus in terms of management strategies. We present the case of a 52-year-old patient with a complex medical history, marked by multiple chronic medical conditions. The patient was diagnosed with primary splenic lymphoma, specifically the diffuse large B-cell subtype. Treatment for our patient involved a shortened course of chemotherapy (4 cycles of R-CHOP followed by two doses of rituximab) due to issues related to compliance and treatment-related complications. This was followed by consolidative radiotherapy, without resorting to splenectomy. Remarkably, the patient achieved complete resolution, and a positron emission tomography (PET) scan conducted at the end of the 6-month post-treatment period confirmed sustained complete remission.