Investigation of a family suspected of being at high risk for cancer

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AI-generated summary by claude@2026-06, 2026-06-10

Researchers investigated cancer in a five-generation family of 199 members, finding an excess of cancer cases in only one generation compared to expected numbers.

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Abstract

The investigation of the family of a patient with bilateral breast cancer is described. By means of interviews and the checking of hospital records and death certificates, information was obtained on 199 family members over five generations, 19 of whom had cancer. Comparison with expected numbers of cases showed an excess in only one generation. The interpretation of these findings and the advice given to family members are discussed.

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Condition tags

endometriosis

MeSH descriptors

Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Adult Aged Brain Neoplasms Brain Neoplasms Breast Neoplasms Breast Neoplasms Carcinoma, Intraductal, Noninfiltrating Carcinoma, Intraductal, Noninfiltrating Cecal Neoplasms Cecal Neoplasms Endometriosis Endometriosis Female Humans Leukemia Leukemia Lymphoma, Non-Hodgkin Lymphoma, Non-Hodgkin

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Source provenance

europepmc
last seen: 2026-07-09T06:07:56.200469+00:00
pubmed
last seen: 2026-05-14T05:58:48.767648+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine