Effect of Liuzijue Breathing Exercise on Patients With Stable Chronic Obstructive Pulmonary Disease: A Systemic Review and Meta-analysis

Abstract Backgrounds:Chronic obstructive pulmonary disease(COPD) is a common,preventable disease of airflow limitation that accounts for the third lec deaths in the worldwide.Health benefits of Liuzijue breathing exercise on patients with stable COPD has been assessed.This study was designed to perform a systemic review and meta-analysis of the effect of Liuzijue breathing exercise on patients with stable COPD.Methods: Published articles from inception to 2020 were conducted using electronic searches. Data extraction was performed by two independents reviewers.The Cochrane risk of bias assessment tool was used to assess the quality of the included studies.Results:A total of 16 eligible trials with 1039 patients with stable COPD were identified. Compared with control group,the pool meta-analysis of Liuzijue breathing exercise showed a significant improve in FEV1 [MD=-0.16,95%CI (0.09,0.23), P<0.00001], FEV1% [MD=9.71, 95%CI(8.44,10.98), P<0.00001], FEV1/FVC(%) [MD=4.81,95%CI(2.12,7.51),P=0.0005],6MWD [MD=21.89,95%CI（14.67, 29.11）,P<0.00001] , health-related quality of life [SMD=-0.84,95%CI（-1.12,-0.55，P<0.00001] and mMRC [MD= -0.73,95%CI (-0.96,-0.50), P<0.00001]. The observed effect was more pronounced for interventions that were short term and medium-term duration of study. Liuzijue interventions also showed improvement in the secondary outcome measures.Conclusions:In this systematic review and meta-analysis ,Liuzijue breathing exercise can improve lung function,exercise endurance and health-related quality of life of patients with stable COPD.Systematic Review Registration: https://www.crd.york.ac.uk/prospero/#myprospero PROSPERO registration number:CRD42020209191.