Biomechanical resilience of the femoral neck post-remission of Cushing’s Syndrome: a comparative analysis using QCT-based Finite Element models

ABSTRACT This study aims at evaluating femoral bone-related mechanical properties in female patients with long-term remission of Cushing’s Syndrome (CS). Sixty-four female subjects were included in this study and stratified in two groups: (a) 32 long-term remission of CS patients, and (b) 32 healthy (paired) control subjects. Quantitative Computed Tomography (QCT) was used to derive patient-specific Finite Element (FE) models. A sideways-fall impact was simulated for each subject and the resulting stress and strain values were compare among the two different groups. Our findings indicate that women with CS in remission exhibit impaired biomechanical properties in the femoral neck compared to controls, suggesting compromised bone properties in this population.