PCBP1 overexpression protects dopaminergic neurons in a model of Parkinson's disease

PCBP1, known as poly(C)-binding protein, is a multifunctional protein produced by reverse transcription of the full-length mRNA of PCBP2. PCBP1 can regulate gene expression at the transcriptional level and can physically interact with other cellular proteins to alter their functional pathways. In our team's previous studies, overexpression of PCBP1 has been found to be closely related to oxidative stress, protein ubiquitination pathway, and iron death. In the present study, we provide evidence for a neuroprotective role of PCBP1 in dopaminergic neurons. Our data suggest that increased expression of PCBP1 in PC12 cells attenuates cellular damage caused by MPTP, including attenuated apoptosis and improved mitochondrial membrane potential. Overall, our data suggest a neuroprotective role for PCBP1 overexpression in dopaminergic neurons. These findings suggest that PCBP1 may have great therapeutic potential for the treatment of diseases associated with dopaminergic neuron loss, such as PD.